A label-free aptasensor FET based on Au nanoparticle decorated Co<sub>3</sub>O<sub>4</sub>nanorods and a SWCNT layer for detection of cardiac troponin T protein

Surya, Sandeep G.; Majhi, Sanjit Manohar; Agarwal, Deepti; Lahcen, Abdellatif Ait; Yuvaraja, Saravanan; Chappanda, Karumbaiah N.; Salama, Khaled N.

doi:10.1039/c9tb01989h

Cited by 35 publications

(16 citation statements)

References 40 publications

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“… 33 Nanomaterials with excellent optoelectronic properties greatly improve the detection sensitivity by orders of magnitude. 21 , 34 , 35 , 36 , 37 , 38 With ZnSnO 3 perovskite nanomaterial-decorated glassy carbon electrodes, Singh et al. designed a label-free EC biosensor to detect TnT.…”

Section: Nanotechnology Approaches To Detect Cadsmentioning

confidence: 99%

Nanotechnology for cardiovascular diseases

Fang

et al. 2022

The Innovation

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Section: Nanotechnology Approaches To Detect Cadsmentioning

confidence: 99%

Nanotechnology for cardiovascular diseases

Fang

et al. 2022

The Innovation

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“…111 Surya et al reported a FETbased cTnT aptasensor based on Au-decorated Co 3 O 4 nanorods (NRs) and SWCNTs (Au-Co 3 O 4 /SWNTs) as a receptor-cum-channel layer (Figure 6(b)). 109 The FET device was fabricated by the attachment of streptavidin protein onto the Au-Co 3 O 4 /SWNTs with the subsequent binding of biotinylated DNA aptamer by biotinstreptavidin chemistry. The binding of cTnT induced the variation in drain current of the FET device with a sensitivity of 0.5 μA/μg/mL.…”

Section: Electrochemical Aptasensors For Cardiac Troponin Tmentioning

confidence: 99%

Advances in electrochemical aptasensing for cardiac biomarkers

Rahman

Lopa

Lee

2021

Bulletin Korean Chem Soc

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Novel bio-receptors or bio-recognition molecular markers with high specificity, stability, and affinity for the efficient binding and entrapment of target biomolecules are essential for developing biomedical devices with high sensitivity and reliability. Aptamers are peptide or nucleic-acid (DNA or RNA) molecules capable of binding to target biomarkers by forming a unique three-dimensional structure, providing an effective platform for biosensing. This review comprehensively summarizes the progress of label-free and label-based electrochemical aptasensors for the detection of various biomarkers related to cardiovascular diseases. It also outlines the fundamental properties of different cardiac biomarkers, synthesis of target-specific aptamers, and working principles, such as single receptor and sandwich, of the different types of sensing assays for the electrochemical detection of cardiac biomarkers while highlighting the current challenges and future perspectives.

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“…Recently, Salama's group used a synergistic combination of AuNPs with Co 3 O 4 for TnT detection in a FET approach. 203 Additionally, Sharma et al developed immunosensors for electrical detection of TnT using rGO sheets. 204 Furthermore, Cristea's group demonstrated the use of a label-free electrochemical aptasensor based on polypyrrole and AuNPs for IL-6 detection in human serum.…”

Section: Aptasensors For Detection Applicationsmentioning

confidence: 99%

“…After TnI binding, hydroquinone (HQ) is oxidized to benzoquinone (BQ) via an enzymatic reaction; the reversible process resulted in the measurement of TnI with a LOD of 16 pg/mL. Recently, Salama’s group used a synergistic combination of AuNPs with Co 3 O 4 for TnT detection in a FET approach . Additionally, Sharma et al developed immunosensors for electrical detection of TnT using rGO sheets .…”

Section: Aptasensors For Detection Applicationsmentioning

confidence: 99%

Recent Developments in Aptasensors for Diagnostic Applications

Liu

Wang

et al. 2020

ACS Appl. Mater. Interfaces

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Aptamers are exciting smart molecular probes for specific recognition of disease biomarkers. A number of strategies have been developed to convert target−aptamer binding into physically detectable signals. Since the aptamer sequence was first discovered, a large variety of aptamer-based biosensors have been developed, with considerable attention paid to their potential applications in clinical diagnostics. So far, a variety of techniques in combination with a wide range of functional nanomaterials have been used for the design of aptasensors to further improve the sensitivity and detection limit of target determination. In this paper, the advantages of aptamers over traditional antibodies as the molecular recognition components in biosensors for high-throughput screening target molecules are highlighted. Aptamer−target pairing configurations are predominantly single-or dual-site binding; the design of recognition modes of each aptamer−target pairing configuration is described. Furthermore, signal transduction strategies including optical, electrical, mechanical, and masssensitive modes are clearly explained together with examples. Finally, we summarize the recent progress in the development of aptamer-based biosensors for clinical diagnosis, including detection of cancer and disease biomarkers and in vivo molecular imaging. We then conclude with a discussion on the advanced development and challenges of aptasensors.

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A label-free aptasensor FET based on Au nanoparticle decorated Co₃O₄nanorods and a SWCNT layer for detection of cardiac troponin T protein

Abstract: Acute myocardial infarction (AMI) is a serious health problem that must be identified in its early stages. Here, we report a FET device with combination of novel nanomaterials and SWCNTS for the detection of Troponin-T.

Cited by 35 publications

References 40 publications

Nanotechnology for cardiovascular diseases

Nanotechnology for cardiovascular diseases

Advances in electrochemical aptasensing for cardiac biomarkers

Recent Developments in Aptasensors for Diagnostic Applications

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A label-free aptasensor FET based on Au nanoparticle decorated Co3O4nanorods and a SWCNT layer for detection of cardiac troponin T protein

Abstract: Acute myocardial infarction (AMI) is a serious health problem that must be identified in its early stages. Here, we report a FET device with combination of novel nanomaterials and SWCNTS for the detection of Troponin-T.

Cited by 35 publications

References 40 publications

Nanotechnology for cardiovascular diseases

Nanotechnology for cardiovascular diseases

Advances in electrochemical aptasensing for cardiac biomarkers

Recent Developments in Aptasensors for Diagnostic Applications

Contact Info

Product

Resources

About

A label-free aptasensor FET based on Au nanoparticle decorated Co₃O₄nanorods and a SWCNT layer for detection of cardiac troponin T protein