A Kinetic spectrophotometric method for determination of amlodipine and Nifedipine in pharmaceutical preparations

Abstract

A simple, accurate, sensitive and economical procedure for the estimation of amlodipine besylate and nifedipine, both in pure and dosage forms, has been developed. The method is based on the reduction of iron(III) by the studied drugs and subsequent interaction of iron(II) with ferricyanide to form Prussian blue. The reaction develops through a slow kinetics and completes in about 10 min. Both initial slope and fixed time methods were used to derive calibration graphs. The resulted calibration equations were linear in the concentration ranges of 1.0-20.0 and 3.0-19.0 ȝg ml -1 for AML and NIF, and the detection limits were 0.10 and 0.19 ȝg ml -1 , respectively. Seven replicate analyses of solutions containing three different levels of each drug resulted in very low relative error of prediction (less than 1.6%) and relative standard deviation (less than 4%) confirming accuracy and precision of the proposed method. The proposed method was applied to the determination of these drugs in pharmaceutical formulations and excellent recoveries were obtained.

Spectrophotometric determination of ethionamide in pharmaceuticals using Folin–Ciocalteu reagent and iron(III)-ferricyanide as chromogenic agents

“…In the PB method, due to the reducing nature of ETM, iron(III) was reduced to iron(II) in acid medium. Subsequently, the iron(II) formed in situ reacted with ferricyanide to form soluble Prussian blue, [KFe III [Fe II (CN) 6 ]] similar to previous reports [40][41][42][43][44][45]. Prussian blue also absorbs maximally at 760 nm (Fig.…”

A Nanodrop Spectrophotometric Method and Stability Indicating for Determination of Amlodipine Besylate in Pharmaceutical Formulations of Kurdistan of Iraq

“…It belongs to a class of medications called dihydropyridine which is a calcium channel blocker acts by relaxing the smooth muscle in the arterial wall, and causes reducing blood pressure (Bernard et al, 2011). In reviewi ng the literature, many analytical methods were developed and validated for determination of AB alone or in combination with other drugs including spectrophotometry (Pradeep et al , 2009 ;Priyanka et al, 2012;Kumar et al, 2019;Kushwaha et al, 2019;Attimarad et al , 2019) , thin layer chromatography (TLC) ( Meyyanathan etal., 2005;Sharma et al , 2014 ;Mathew et al, 2014), high performance liquid chromatography (HPLC) Chitlange et al, 2008;(Jadhav et al, 2013 ;Rima et al , 2013 ;Mohamed et al,2019) and, kinetic ( Hemmateenejad et al, 2009;Mahmoud et al, 2012). Stability indicating is an important part of the process of the pharmaceutical product development.…”

Magnetism study of CI xCoy[Fe(CN)6]·zH2O (CI=Rb,Cs) Prussian blue nanoparticles

“…Prussian blue analogues are a group of important functional materials due to their special properties in electrocatalytic, [1][2][3] electrochromic, [4] ion sieving, [5,6] photomagnetic, [7][8][9][10][11][12][13][14][15] kinetic spectrophotometeric field [16] and so on. In 1996, Hashimoto and co-wokers first described that spectacular magnetization changes could be induced photochemically in a magnetic molecule-base Prussian blue analogue of K 0.2 Co 1.4 Fe(CN) 6 ·6.9H 2 O.…”