A keratoprosthesis successfully implanted in the cornea of a rabbit, a SEM-study

Jongebloed, W.L.; Andel, Pek van; Humalda, D.; Worst, Jgf

doi:10.1007/bf00142364

Cited by 3 publications

(5 citation statements)

References 7 publications

(7 reference statements)

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“…In area B no fibre structure existed yet; a large number of fibrils had assumed a certain main direction without the formation of actual fibres. This is comparable to the initial deposition of fibres onto the PMMA-surface of a keratoprosthesis on the epithelial side of the cornea [1].…”

Section: Discussionsupporting

confidence: 51%

Soemmering's ring, an aspect of secondary cataract: A morphological description by SEM

et al. 1988

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A Soemmering's ring attached to a patient's I.O.L. was removed and processed for SEM-examination. The enveloping structure of the Soemmering's ring was clearly of capsular origin, adherent along a single line and forming an envelope around the inner material. The envelope had a membranous character. The contents of the ring varied from the outside to the centre. Close to the capsule envelope a more or less amorphous material was found. Most of the contents of the ring was made up of lens-fibre material. Sometimes clear lens fibres were visible with densely packed lens-fibre proteins, sometimes with clusters of recrystallized proteins, rod-shaped or spherical, surrounded by what appeared to be amorphous material. The recrystallized and the amorphous lens-fibre material are similar to material found in cataractous lenses.

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Section: Discussionsupporting

confidence: 51%

Soemmering's ring, an aspect of secondary cataract: A morphological description by SEM

et al. 1988

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“…and OsO4 solutions, dehydrated in ethanol and critical-point dried in liq. CO2 as described before [6].…”

Section: Methodsmentioning

confidence: 99%

“…Worst). The thin, 50 pm dia., wire is highly flexible and is used in I.O.L.-implantation, as well as in keratoprothesis fixation and standard wound closure, with success [6]. The aim of this investigation was to study experimentally the acceptance of the stainless steel-vanadium material by the cornea of the rabbits and its acceptance by a human cornea when used as a fixation suture for an I.O.L.…”

Section: Introductionmentioning

confidence: 99%

Stainless steel as suturing material in human- and rabbit corneas: A SEM-study

Jongebloed

Rijneveld²,

Cuperus

et al. 1988

Doc Ophthalmol

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Stainless steel wire, dia. 50 microns, was used as suturing material in rabbit corneas for periods of 1.5, 3 and 7 months respectively, in order to test its inertness and acceptance by the corneal tissue. One clinical case of stainless steel wire used for fixation of an I.O.L.-implantation, after a 5-year residence in the eye, is reported as well. After 1.5 months' residence, the suture margins were well covered with tissue containing irregularly shaped endothelial cells, some fibroblastic-type cells and various kinds of collagenous fibre material. The buckled surface was partly covered with a very thin membrane of collagenous material, strands of collagenous fibres and a few fibroblastic-type cells. After 3 months' residence the buckle was almost completely covered with an endothelial cell layer. The individual cells had a somewhat irregular hexagonal shape. At a few local sites closure was still progressing, with filopodia and other collagenous matter generated by neighbouring cells on top of previously deposited Descemet's membrane. After 7 months' residence, the buckle was completely covered with normal endothelium. The fixation suture in the human case showed perfect acceptance by the corneal tissue.

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“…The cornea with KP was quickly removed, prepared for (S)EM and LM in the usual way [5], and examined. In Fig.…”

Section: The Platinum-glass Kpmentioning

confidence: 99%

“…In the past and present various designs and materials have been tested and are still being tested [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Glass-metal keratoprosthesis: Light and electron microscopical evaluation of experimental surgery on rabbit eyes

et al. 1989

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A keratoprosthesis (KP) is the last and only surgical resort to regain some visual acuity in eyes with severely damaged corneae. Corneal blindness represents an important percentage of the blind in the economically poor countries. Commercially available KP's, e.g. those made of PMMA, which are difficult to sterilize and vulnerable to surface damage, are too expensive in these countries. To overcome these disadvantages, we developed a new KP, made of a glass core melted into a platinum cylinder with flange. They were implanted unilaterally in eyes of ten Hollander rabbits intralamellarly. They were fixated by two stainless steel traction threads passed around the whole eyeball. We investigated this type of KP in the rabbit cornea, its acceptance by stroma, epi- and endothelium, and its hydro-mechanical dynamics in situ. No signs of infection or extrusion were observed. No epithelial downgrowth, nor adverse tissue reaction could be detected. LM and SEM showed endothelialization of the newly formed stroma around the central column of the KP. We conclude that this type of KP (although optically still to be optimized) has been accepted by the rabbit cornea and a clinical trial on cornea-blind patients is justified.

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A keratoprosthesis successfully implanted in the cornea of a rabbit, a SEM-study

Cited by 3 publications

References 7 publications

Soemmering's ring, an aspect of secondary cataract: A morphological description by SEM

Soemmering's ring, an aspect of secondary cataract: A morphological description by SEM

Stainless steel as suturing material in human- and rabbit corneas: A SEM-study

Glass-metal keratoprosthesis: Light and electron microscopical evaluation of experimental surgery on rabbit eyes

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