A Juvenile Case of Pulmonary Lymphangitic Carcinomatosis Caused by Sigmoid Colon Cancer with a Component of Micropapillary Carcinoma

Otsubo, Kenji; Kubo, Naoki; Nakashima, Naotoshi; Izumi, Miiru; Nakamori, Mari; Kojima, Hiroshi

doi:10.2169/internalmedicine.50.5170

Cited by 16 publications

(6 citation statements)

References 15 publications

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“…Invasive micropapillary carcinoma arising in the colon has been for the first time been reported by Sakamoto et al [7]. To date, the majority of reported cases are single case report [8,9,10,11,12,13,14,15]. However, there are only a few reports on a large scale clinicopathological study of colon cancer with MPP [16,17,18,19,20].…”

Section: Introductionmentioning

confidence: 99%

Colon cancer with micropapillary carcinoma component: a clinopathologic study of 9 cases

Yorita¹

2017

pjp

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Recently, colon cancer with micropapillary pattern (MPP) has been identified. MPP is defined as tight tufts surrounded by cleft-like space and lacking true fibrovascular cores and showing reverse polarity. In this article, we studied nine cases of colon cancer with MPP. MPP usually accounted for a minor component in total tumour volume, which ranged from 3 to 40% with a mean percentage of 19.2%. Associated histological subtype showed moderately differentiated tubular adenocarcinoma in all cases. The reverse polarity of villin (9/9, diffuse) in MPP component was superior to that of CA125 (5/9, focal) or CD10 (5/9, diffuse 2/9, focal 3/9). In clinicopathological indicators such as sex, tumour location, tumour depth, lymphovascular invasion, lymph node metastasis, or pathological stage and clinical behaviour, there was statistically no difference between the MPP group and the non-MPP group of the colon. In conclusion, colon cancer with MPP is characterised by frequent association with moderately differentiated tubular adenocarcinoma as a minor component. Villin immunohistochemistry is useful in the detection of reverse polarity of MPP of colon cancer.

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Section: Introductionmentioning

confidence: 99%

Colon cancer with micropapillary carcinoma component: a clinopathologic study of 9 cases

Yorita¹

2017

pjp

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“…Beginning in 2005, several case series and case reports were published on MP CRC, elucidating its clinical behaviour, genetic properties and prognosis. In general, this subtype of colorectal adenocarcinoma presents as locally advanced disease, displays a tendency towards lymphovascular invasion and lymph node metastasis and reportedly imparts a poor prognosis compared to conventional CRC .…”

Section: Introductionmentioning

confidence: 99%

Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial–mesenchymal transition

et al. 2016

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Aims Colorectal carcinoma (CRC) with micropapillary (MP) features has only been recently described and is still being characterized. Methods and Results We reviewed the clinicopathologic and molecular features of 42 CRC with MP features. Twenty-nine cases were also evaluated for immunohistochemical evidence of epithelial-mesenchymal transition (EMT). The extent of MP features within our cohort ranged from 5% (13 cases) to 100% (1 case). Twenty-seven cases featured prominent cribriforming with dirty necrosis in the non-MP component; nine displayed mucinous features. Twenty-four of 29 cases (83%) demonstrated evidence of EMT. Thirty-six cases (86%) showed advanced T-category (pT3 or pT4), 31 (74%) had lymph node metastases, and 23 (55%) had distant metastases. Median overall follow-up was 36 months. Seventeen patients (40%) died of disease, with median survival of 23 months. Mutations were seen in 17 of 31 tested cases (55%), including 11 KRAS mutations and 4 BRAF V600E mutations. Microsatellite instability testing was performed on 21 cases; all were microsatellite-stable. Compared to a cohort of 972 conventional CRC, MP CRC was more likely to present as Stage IV disease (P<0.001), but patients with MP CRC showed no significant differences in overall survival after adjusting for stage. Conclusions MP features in CRC portend a high likelihood of advanced local disease and distant metastases. MP CRC is often associated with a cribriform pattern elsewhere in the tumour and cystic nodal metastases with prominent necrosis. They also show frequent mutations in KRAS and BRAF. Immunohistochemical evidence of EMT is common in MP CRC.

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“…This variant has also been reported in breast, bladder, lung, and prostate carcinomas [4]. Lymphangitic lung carcinomatosis from micropapillary colon adenocarcinoma has only been previously reported in an autopsy case [3].…”

Section: Introductionmentioning

confidence: 84%

Metastatic colorectal micropapillary carcinoma presenting as lymphangitic lung carcinomatosis

López‐García

Garcia-Hernandez

López-Sotomayor

et al. 2020

Clin J Gastroenterol

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Pulmonary lymphangitic carcinomatosis denotes the infiltration of tumor cells into the lung parenchymal lymphatic channels. Breast, lung, stomach, and colon adenocarcinoma are the most common origin of this invasion pattern. The micropapillary variant of colorectal adenocarcinoma has a high rate of lymph node metastases and poor overall survival. A 49 year-old man with a 6 months history of persistent cough and a relevant occupational chemical exposure had a computed tomography that showed bilateral interstitial lung infiltrates. The lung biopsy demonstrated a micropapillary adenocarcinoma with diffusely obstruction of the lung parenchymal lymphatics. The immunohistochemistry confirmed a colorectal origin. The colonoscopy evidenced a mass with identical morphology. Colorectal micropapillary carcinoma with metastatic lung lymphangitic carcinomatosis can occur, as a persistent cough, as presenting symptom in extraordinarily rare cases. To the best of our knowledge, this is the first case of an alive patient with colorectal metastatic micropapillary carcinoma presenting with lymphangitic lung carcinomatosis.

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A Juvenile Case of Pulmonary Lymphangitic Carcinomatosis Caused by Sigmoid Colon Cancer with a Component of Micropapillary Carcinoma

Cited by 16 publications

References 15 publications

Colon cancer with micropapillary carcinoma component: a clinopathologic study of 9 cases

Colon cancer with micropapillary carcinoma component: a clinopathologic study of 9 cases

Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial–mesenchymal transition

Metastatic colorectal micropapillary carcinoma presenting as lymphangitic lung carcinomatosis

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