Colon cancer with micropapillary carcinoma component: a clinopathologic study of 9 cases

Yorita, Kenji

doi:10.5114/pjp.2017.69685

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…The current IHC results were consistent with those reported in the literature (19,20,22), demonstrating that, when identifying the MPC of CRC, the sensitivity and specificity of villin is higher compared with that of E-cadherin and EMA. E-cadherin is one of the immunomarkers of MPC (27,37,38), but the current study and previous studies showed that it often had no staining or only partial staining (35).…”

Section: Discussionsupporting

confidence: 91%

“…The present bioinformatics analysis demonstrated that EMA had the lowest sensitivity in COAD compared with villin and E-cadherin, as reported by previous studies (20,22,23,25). A previous study reported that villin detection using IHC is useful in the detection of reverse polarity of MPP (19).…”

Section: Discussionsupporting

confidence: 82%

“…This pattern was described first in the breast (12) and ovarian cancer (13) and subsequently in other locations, including the urothelial (14), gastrointestinal (15), lung (16) and salivary gland cancer (17). An increasing number of studies have reported that MPC is an aggressive variant of colorectal adenocarcinoma (4,11,18,19). However, there are only a few preliminary studies with small samples of CRC with micropapillary pattern (MPP) and a few case reports of clinicopathological studies.…”

Section: Introductionmentioning

confidence: 99%

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Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma

Zhao

Liu

et al. 2020

Oncol Lett

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Colorectal cancer (CRC) is a common malignant tumor of digestive system. CRC with micropapillary pattern (MPP) is an aggressive variant of colorectal adenocarcinoma. The aim of the present study was to clarify the clinicopathological significance and the prognostic role of an immunohistochemical marker, MPP, in CRC. The association between MPP and clinicopathological characteristics and prognosis in 286 cases of CRC (286/453 cases had follow-up information) were analysed. Then, 81 tissues without MPP and 90 tissues with MPP were analysed by immunohistochemistry using antibodies against villin, E-cadherin and epithelial membrane antigen (EMA). Bioinformatics was used to evaluate the expression of these three indicators in CRC. The proportion of micropapillary carcinoma in the overall tumour was ≥5%, and was observed in 90/453 cases (19.8%). The present data showed that CRC with MPP displayed higher rates of vascular and lymphatic invasion, a higher metastatic lymph node ratio and a higher pathological tumour and metastasis stage compared with CRC without MPP. The positive expression rates of EMA, E-cadherin and villin were 50.3, 93.4 and 96.5%, respectively. In 90 CRC cases with MPP, EMA inside-out pattern (I/OP) staining was observed in 26 cases (28.9%), and it was often focal and partial, while 37 cases (41.1%) had E-cadherin focal and partial staining compatible with reverse polarity. Villin I/OP staining was observed in 77 cases (85.6%), and circumferential staining predominated over partial staining. Overall, the data suggested that the presence of MPP is significantly associated with aggressive tumour behaviour and worse overall survival rate in CRC. Visualization and distinction of reverse polarity of colorectal micropapillary carcinomas is improved villin compared with EMA or E-cadherin.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

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Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma

Zhao

Liu

et al. 2020

Oncol Lett

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“…We defined PDC showing reversed polarity with empty spaces around the clusters as PDC with micropapillary (MP) features (Figure B). Reversed polarity was certified by villin immunohistochemistry . When PDC with MP features occupied all the ×20 objective lens field, we designated the corresponding case as MP PDC‐positive.…”

Section: Methodsmentioning

confidence: 99%

Clinicopathological significance of heterogeneic ezrin expression in poorly differentiated clusters of colorectal cancers

et al. 2019

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Multicellular structures, such as tumor buddings and poorly differentiated clusters (PDC), exist at the invasive front of colorectal cancers (CRC). Although it has been reported that CRC with PDC showed frequent lymph node metastases with a worse prognosis, the molecular markers of PDC that are responsible for prognosis have not been identified. We here noticed for the first time that Ezrin, a regulator of the actin cytoskeleton, is expressed in the corner cells of PDC. We then aimed to verify whether heterogeneous Ezrin expression in PDC predicts the prognosis of CRC patients. We immunohistochemically analyzed Ezrin expression in PDC of 184 patients with completely resected stages I‐III CRC. We established the Ezrin corner score (ECS), which quantifies the tendency of Ezrin‐positive cells to accumulate at the corners of PDC. On the basis of ECS values, 2 indices, the mean ECS and the number of PDC with high ECS, were obtained. Both indices were significantly higher in CRC with lymphatic invasion, higher PDC grade, and presence of micropapillary (MP) PDC. The mean ECS‐high group showed shorter recurrence‐free survival than the mean ECS‐low group but without significance. The other index, the number of ECS‐high PDC, was significantly associated with recurrence‐free survival. These results suggest that Ezrin is involved in PDC progression and lymphatic invasion, and that ECS may be a marker for aggressive PDC.

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“…Villin is associated with elimination of polarity that the epithelium exhibits, thus altering tissue architecture ( 40 ). Thus, in CRCs containing a micropapillary pattern, villin IHC has been effective for tracking the polarity in this type of CRC ( 41 ). The specificity of villin as a marker of intestinal origin is limited, similar to CDX2, as positivity may also be marked in adenocarcinomas with intestinal differentiation arising from a wide variety of organs including stomach, lung, and ovary as well as in malignancies of other sites such as the endocervix and liver (the latter more rarely, though) ( 42 ).…”

Section: Diagnostic Markersmentioning

confidence: 99%

Improving diagnosis, prognosis and prediction by using biomarkers in CRC patients (Review)

et al. 2018

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Colorectal cancer (CRC) is among the most common cancers. In fact, it is placed in the third place among the most diagnosed cancer in men, after lung and prostate cancer, and in the second one for the most diagnosed cancer in women, following breast cancer. Moreover, its high mortality rates classifies it among the leading causes of cancer-related death worldwide. Thus, in order to help clinicians to optimize their practice, it is crucial to introduce more effective tools that will improve not only early diagnosis, but also prediction of the most likely progression of the disease and response to chemotherapy. In that way, they will be able to decrease both morbidity and mortality of their patients. In accordance with that, colon cancer research has described numerous biomarkers for diagnostic, prognostic and predictive purposes that either alone or as part of a panel would help improve patient's clinical management. This review aims to describe the most accepted biomarkers among those proposed for use in CRC divided based on the clinical specimen that is examined (tissue, faeces or blood) along with their restrictions. Lastly, new insight in CRC monitoring will be discussed presenting promising emerging biomarkers (telomerase activity, telomere length and micronuclei frequency).

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Colon cancer with micropapillary carcinoma component: a clinopathologic study of 9 cases

Cited by 8 publications

References 19 publications

Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma

Villin is a biomarker for reverse polarity in colorectal micropapillary carcinoma

Clinicopathological significance of heterogeneic ezrin expression in poorly differentiated clusters of colorectal cancers

Improving diagnosis, prognosis and prediction by using biomarkers in CRC patients (Review)

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