A hypothesis to relate salivary tumors with mammary and prostate neoplasias

Actis, Adriana Beatriz

doi:10.6026/97320630001012

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…Consequently, they lead us to consider salivary glands as potent endocrine disruptor targets. In this way, SSG share some similar characteristics with mammary glands in terms of morphology, sex hormone dependency, cellular mechanisms, and tumor histopathology (Actis 2005). We therefore hypothesized that female SSG morphogenesis and properties could be similarly affected by early exposure to endocrine disruptors (El Sheikh Saad et al 2011).…”

Section: Introductionmentioning

confidence: 99%

In Utero and Lactational Exposure to Low-Dose Genistein-Vinclozolin Mixture Affects the Development and Growth Factor mRNA Expression of the Submandibular Salivary Gland in Immature Female Rats

Kouidhi

Desmetz²,

Nahdi

et al. 2012

Toxicol Pathol

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It has been suggested that hormonally controlled submandibular salivary gland (SSG) development and secretions may be affected by endocrine disruptor compounds. We investigated the effects of oral gestation-lactation exposure to 1 mg/kg body weight daily dose of the estrogenic soy-isoflavone genistein and/or the anti-androgenic food contaminant vinclozolin in female rats. The SSGs of female offspring were collected at postnatal day 35 to study gland morphogenesis and mRNA expression of sex-hormone receptors and endocrine growth factors as sex-dependent biomarkers. Because of high expression in neonatal SSG, mRNA expression of transforming growth factor a was also studied. Exposure to genistein, vinclozolin, or a genisteinþvinclozolin mixture resulted in significantly lower numbers of striated ducts linked to an increase in their area and lower acinar proliferation (Ki-67-positive nuclei). Exposure to the mixture had the highest significant effects, which were particularly associated with repression of epidermal growth factor, nerve growth factor, and transforming growth factor a expression. In conclusion, early exposure to low doses of genistein and vinclozolin can affect glandular structure and endocrine gene mRNA expression in prepubertal SSG in female rats, and the effects are potentialized by the genisteinþvinclozolin mixture. Our study provides the first evidence that SSG are targeted by both estrogenic and anti-androgenic disrupting compounds and are more sensitive to mixtures.

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Section: Introductionmentioning

confidence: 99%

In Utero and Lactational Exposure to Low-Dose Genistein-Vinclozolin Mixture Affects the Development and Growth Factor mRNA Expression of the Submandibular Salivary Gland in Immature Female Rats

Kouidhi

Desmetz²,

Nahdi

et al. 2012

Toxicol Pathol

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“…Actis indicated a certain connection and a similarity of histopathological types between the tumours of the salivary glands, breast, and prostate tumours. Thus, the structure of pleomorphic adenoma is very similar to a mucocellular tumour of the breast gland [16] .…”

Section: Discussionmentioning

confidence: 95%

“…Thus, the influence of persistent viral infections on the development of various types of tumours and their endocrine dependence has already been sufficiently studied. In particular, it is known of the role of human papilloma virus (types 6,8,16,18) in the development of cervical cancer [5,6] , as well as the effect of hyperestrogenemia on the development of tumours in the mammary glands [7] . It is also known that the accuracy of morphological verification, as a rule, is no more than 85%.…”

Section: Introductionmentioning

confidence: 99%

Complex immunohistochemical evaluation of pleomorphic adenomas of the salivary glands

Aleksandrovich¹,

Brodetskyi²,

Stanislavovich³

2019

har

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Background: Diagnostic methods are important in modern medicine. Among the most well-known methods are histological and immunohistochemical. Each of the listed methods is used for diagnostics of various human neoplasms, in particular, tumours of the salivary glands. Thus, most sources and scientific articles attempt to evaluate and carry out the diagnosis of tumours of the salivary glands (pleomorphic adenomas) by only one immunohistochemical criterion, while a complex approach is used only in individual cases. The purpose of the research was to conduct a comprehensive immunohistochemical evaluation of pleomorphic adenomas of the salivary glands. Materials and Methods: Diagnostic methods are important in modern medicine. Among the most well-known methods are histological and immunohistochemical. Each of the listed methods is used for diagnostics of various human neoplasms, in particular, tumours of the salivary glands. Thus, most sources and scientific articles attempt to evaluate and carry out the diagnosis of tumours of the salivary glands (pleomorphic adenomas) by only one immunohistochemical criterion, while a complex approach is used only in individual cases. The purpose of the research was to conduct a comprehensive immunohistochemical evaluation of pleomorphic adenomas of the salivary glands. Results: The analyses of the research showed that the parotid salivary gland was affected in most of the patients with pleomorphic adenomas. Among the viruses that were present-19 (67.85%) patients had HPV type 16, and 8 (28.57%) patients had the Epstein-Barr virus dominating. Among the hormones, the distribution was as follows: 3 (10.7%)-progesterone, 2 (7.14%)-oestrogen. PLAG1 had the highest expression in the parotid salivary gland tissues-24 (88.88%). Conclusion: The complex evaluation of the immunohistochemical parameters of the pleomorphic adenomas of the salivary glands (mainly in the parotid salivary glands) has established the presence of 5 markers: ER (oestrogen), PR (progesterone), HPV type 16, EBV, and PLAG1.

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“…Thus, among the main ones are androgen, estrogen, and progesterone -hormones that act through specific receptors and that play an important role in the growth and the development of several tumors, including breast, endometrial, and prostate carcinoma [8]. (Actis A.B., 2005) indicated a certain connection and a similarity of the histopathological types between the tumors of the salivary glands, the breast, and the prostate tumors. Thus, the structure of pleomorphic adenoma is very similar to a mucocellular tumor of the breast gland [17].…”

mentioning

confidence: 99%

Application of immunohistochemical markers in diagnostics of various histological types of pleomorphic adenomas of the salivary glands

2020

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The morphological verification of tumors as a diagnostic method has been the basis for establishing the final diagnosis for a long time. According to various data, the accuracy of the diagnosis ranges from 80–85 %, depending on the type of tumor (benign or malignant) and its differentiation. With the introduction of immunohistochemical studies for the final diagnosis of tumors, the percentage of verified tumors has increased significantly. The aim of the study – determination of peculiarities of pathogenesis of various histological types of pleomorphic adenomas of the salivary glands applying the methods of immunohistochemical diagnostics. Materials and Methods. The study was conducted based on the excisional biopsies of the pleomorphic adenomas of the salivary glands in 28 patients. The immunohistochemistry analyses were performed with Monoclonal Mouse Anti-Epstein Barr Virus, Polyclonal Rabbit Antibody p16, Monoclonal Rabbit Anti-Human Estrogen Receptor (ER), and the Mouse Anti-Human Progesterone Receptor (PR), PLAG1 (pleomorphic adenoma gene 1) Monoclonal Antibody. Results and Discussion. The results of the conducted study of the own surgical material show that the structure of histological types of pleomorphic adenomas of the salivary glands is as follows: mesenchymal 15 (53.57 %), epithelial-mesenchymal – 10 (35.47 %), epithelial – 3 (10.71 %). The mesenchymal and epithelial-mesenchymal types of histological structure of pleomorphic adenomas of the salivary glands are characterized by the similar immunohistochemical peculiarities (Plag1 – positive response in tumor cells of both histological types in 100 % of cases; HPV 16 – 73.33 % and 80.0 % respectively and EBV – 33.33 % and 30.0 % respectively). The epithelial type of structure of the pleomorphic adenomas of the salivary glands is characterized by slightly different immunohistochemical pattern: Plag1 – positive response in tumor cells in 66.66 % of cases; HPV 16 – also in 66.66 % of cases. The mesenchymal and epithelial-mesenchymal types of histological structure of pleomorphic adenomas of the salivary glands are characterized by more frequent invasion of HPV 16 and EBV. Conclusions. The mesenchymal and epithelial-mesenchymal types of histological structure of pleomorphic adenomas of the salivary glands are characterized by more frequent invasion of HPV 16 and EBV.

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A hypothesis to relate salivary tumors with mammary and prostate neoplasias

Cited by 4 publications

References 26 publications

In Utero and Lactational Exposure to Low-Dose Genistein-Vinclozolin Mixture Affects the Development and Growth Factor mRNA Expression of the Submandibular Salivary Gland in Immature Female Rats

In Utero and Lactational Exposure to Low-Dose Genistein-Vinclozolin Mixture Affects the Development and Growth Factor mRNA Expression of the Submandibular Salivary Gland in Immature Female Rats

Complex immunohistochemical evaluation of pleomorphic adenomas of the salivary glands

Application of immunohistochemical markers in diagnostics of various histological types of pleomorphic adenomas of the salivary glands

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