A Hypercaloric pellet-diet cycle induces obesity and co-morbidities in wistar rats

Abstract

The present study was carried to develop and analyze the consequences of hypercaloric pellet-diet cycle that promotes obesity in rats. Male Wistar rats were randomly distributed into two groups that received either normal diet (ND; n =32; 3,5 Kcal/g) or a hypercaloric diet (HD; n =32; 4,6 Kcal/g). The ND group received commercial Labina rat feeding while the HD animals received a cycle of five hypercaloric diets over a 14-week period. The effects of the diets were analyzed in terms of body weight, body composition, hormone-metabolite levels, systolic arterial pressure and glucose tolerance at the 5% significance level. The hypercaloric pellet diet cycle promoted an increase in body weight and fat, systolic arterial pressure and a high serum level of glucose, triacylglycerol, insulin and leptin. The HD group also presented an impaired glucose tolerance. In conclusion, the results of this study show that the hypercaloric pellet-diet cycle promoted obesity in Wistar rats and displayed several characteristics that are commonly associated with human obesity, such as high arterial pressure, insulin resistance, hyperglycaemia, hyperinsulinaemia, hyperleptinaemia and dyslipidaemia.

Obesity and abdominal wound healing in rats

“…In the literature, there are several obesity models, including a lesion of the hypothalamic ventromedial nucleus by administration of monosodium glutamate tonewborn rats 24 ; oophorectomy 25 and hypercaloric diets 18,26,27,28 . The diet used in this study was effective in making the rats gain weight.…”

Efeito da redução de ninhada sobre as respostas autonômicas e metabólicas de ratos Wistar

“…Alterações encontradas para os valores de colesterol total, triglicérides e HDL-c em animais NR apontam para um quadro de dislipidemia, que se relaciona à resultados da literatura 32,33 . Estudos apontam ainda que a obesidade está diretamente associada a comorbidades, como a dislipidemia [5][6][7]20,32 .…”

“…Estudos apontam ainda que a obesidade está diretamente associada a comorbidades, como a dislipidemia [5][6][7]20,32 . O SNA tem papel fundamental no controle metabólico 23,34 .…”

Dieta hiperlipídica com farinha de soja como fonte proteica: utilização na seleção de ratos propensos e resistentes à obesidade

“…A associação entre o consumo de dieta hipercalórica ou hiperlipídica e a predisposição genética, portanto, tem sido considerada, hoje em dia, o modelo mais realista e apropriado para estudos da obesidade [17][18][19] .…”