A Hydrogen Peroxide‐Responsive O<sub>2</sub> Nanogenerator for Ultrasound and Magnetic‐Resonance Dual Modality Imaging

Yang, Fang; Hu, Sunling; Zhang, Yu; Cai, Xiaowei; Huang, Yan; Wang, Feng; Su, Wen; Teng, Gao‐Jun; Gu, Ning

doi:10.1002/adma.201202367

Cited by 124 publications

(99 citation statements)

References 30 publications

(31 reference statements)

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“…The allylhydrazine is encapsulated in liposomes for ease of delivery and to aid in nucleation. In another scheme, Prussian Blue nanoparticles were found to have catalase-like activity that causes breakdown of hydrogen peroxide to form oxygen microbubbles similar to ours [16]. Despite the differences in approaches, each of these detection strategies has a detection limit of 10uM, similar to the scheme presented here.…”

Section: Discussionsupporting

confidence: 59%

Toward in vivo detection of hydrogen peroxide with ultrasound molecular imaging

et al. 2013

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We present a new class of ultrasound molecular imaging agents that extend upon the design of micromotors that are designed to move through fluids by catalyzing hydrogen peroxide (H 2 O 2 ) and propelling forward by escaping oxygen microbubbles. Micromotor converters require 62 mM of H 2 O 2 to move -1000-fold higher than is expected in vivo. Here, we aim to prove that ultrasound can detect the expelled microbubbles, to determine the minimum H 2 O 2 concentration needed for microbubble detection, explore alternate designs to detect the H 2 O 2 produced by activated neutrophils and perform preliminary in vivo testing. Oxygen microbubbles were detected by ultrasound at 2.5 mM H 2 O 2 . Best results were achieved with a 400-500 nm spherical design with alternating surface coatings of catalase and PSS over a silica core. The lowest detection limit of 10-100 µM was achieved when assays were done in plasma. Using this design, we detected the H 2 O 2 produced by freshly isolated PMA-activated neutrophils allowing their distinction from naïve neutrophils. Finally, we were also able to show that direct injection of these nanospheres into an abscess in vivo enhanced ultrasound signal only when they contained catalase, and only when injected into an abscess, likely because of the elevated levels of H 2 O 2 produced by inflammatory mediators.

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Section: Discussionsupporting

confidence: 59%

Toward in vivo detection of hydrogen peroxide with ultrasound molecular imaging

et al. 2013

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“…[288][289][290][291] The unique hollow nanostructure of HMONs can act as CAs for ultrasound imaging because the large hollow nanostructure and thin mesoporous organosilica shell shows excellent echogenic behavior and corresponding contrast-enhanced ultrasound imaging. [292][293][294] Moreover, the large hollow interior and well-defi ned mesopores of benzene-bridged HMONs can be utilized for effi ciently encapsulating the hydrophobic anticancer drug paclitaxel (PTX) for intracellular drug delivery.…”

Section: Reviewmentioning

confidence: 99%

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

2016

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Organic-inorganic hybrid materials aiming to combine the individual advantages of organic and inorganic components while overcoming their intrinsic drawbacks have shown great potential for future applications in broad fields. In particular, the integration of functional organic fragments into the framework of mesoporous silica to fabricate mesoporous organosilica materials has attracted great attention in the scientific community for decades. The development of such mesoporous organosilica materials has shifted from bulk materials to nanosized mesoporous organosilica nanoparticles (designated as MONs, in comparison with traditional mesoporous silica nanoparticles (MSNs)) and corresponding applications in nanoscience and nanotechnology. In this comprehensive review, the state-of-art progress of this important hybrid nanomaterial family is summarized, focusing on the structure/composition-performance relationship of MONs of well-defined morphology, nanostructure, and nanoparticulate dimension. The synthetic strategies and the corresponding mechanisms for the design and construction of MONs with varied morphologies, compositions, nanostructures, and functionalities are overviewed initially. Then, the following part specifically concentrates on their broad spectrum of applications in nanotechnology, mainly in nanomedicine, nanocatalysis, and nanofabrication. Finally, some critical issues, presenting challenges and the future development of MONs regarding the rational synthesis and applications in nanotechnology are summarized and discussed. It is highly expected that such a unique molecularly organic-inorganic nanohybrid family will find practical applications in nanotechnology, and promote the advances of this discipline regarding hybrid chemistry and materials.

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“…However, the detailed cellular mechanism underlying this property of PB-Ft NPs is unclear and requires further investigation. Moreover, Yang et al [118] have developed a new strategy of ultrasound and MR dual modal imaging, which has a complementary advantage that enables simultaneous treatment and multimodal monitoring based on PB-Ft NPs. PB-Ft NPs are able to catalyze the decomposition of H2O2 into oxygen (O2) molecules at neutral pH (pH 7.4).…”

Section: Magnetic Nanoparticles Themselves As a Drug Delivery Systemmentioning

confidence: 99%

Magnetic drug delivery systems

Liu

Yang

et al. 2017

Sci. China Mater.

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There has been unprecedented progress in the development of biomedical nanotechnology and nanomaterials over the past few decades, and nanoparticle-based drug delivery systems (DDSs) have great potential for clinical applications. Among these, magnetic drug delivery systems (MDDSs) based on magnetic nanoparticles (MNPs) are attracting increasing attention owing to their favorable biocompatibility and excellent multifunctional loading capability. MDDSs primarily have a solid core of superparamagnetic maghemite (γ-Fe2O3) or magnetite (Fe3O4) nanoparticles ranging in size from 10 to 100 nm. Their surface can be functionalized by organic and/or inorganic modification. Further conjugation with targeting ligands, drug loading, and MNP assembly can provide complex magnetic delivery systems with improved targeting efficacy and reduced toxicity. Owing to their sensitive response to external magnetic fields, MNPs and their assemblies have been developed as novel smart delivery systems. In this review, we first summarize the basic physicochemical and magnetic properties of desirable MDDSs that fulfill the requirements for specific clinical applications. Secondly, we discuss the surface modifications and functionalization issues that arise when designing elaborate MDDSs for future clinical uses. Finally, we highlight recent progress in the design and fabrication of MNPs, magnetic assemblies, and magnetic microbubbles and liposomes as MDDSs for cancer diagnosis and therapy. Recently, researchers have focused on enhanced targeting efficacy and theranostics by applying step-by-step sequential treatment, and by magnetically modulating dosing regimens, which are the current challenges for clinical applications.

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A Hydrogen Peroxide‐Responsive O₂ Nanogenerator for Ultrasound and Magnetic‐Resonance Dual Modality Imaging

Cited by 124 publications

References 30 publications

Toward in vivo detection of hydrogen peroxide with ultrasound molecular imaging

Toward in vivo detection of hydrogen peroxide with ultrasound molecular imaging

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

Magnetic drug delivery systems

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A Hydrogen Peroxide‐Responsive O2 Nanogenerator for Ultrasound and Magnetic‐Resonance Dual Modality Imaging

Cited by 124 publications

References 30 publications

Toward in vivo detection of hydrogen peroxide with ultrasound molecular imaging

Toward in vivo detection of hydrogen peroxide with ultrasound molecular imaging

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

Magnetic drug delivery systems

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A Hydrogen Peroxide‐Responsive O₂ Nanogenerator for Ultrasound and Magnetic‐Resonance Dual Modality Imaging