Toward in vivo detection of hydrogen peroxide with ultrasound molecular imaging

Olson, Emilia S.; Orozco, Jahir; Wu, Zhe; Malone, Christopher; Yi, Boem-Ha; Gao, Wei; Eghtedari, Mohammad; Wang, Joseph; Mattrey, Robert F.

doi:10.1016/j.biomaterials.2013.06.055

Cited by 95 publications

(104 citation statements)

References 20 publications

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“…The large particle size of MBs, however, hinders their penetration into tumor tissue. Droplet vaporization was recently developed to solve this critical issue . Perfluorohexane (PFH) was encapsulated into small particle‐sized emulsion (200 nm) .…”

Section: Nanoparticle‐augmented But Sonosensitizer‐free Sdtmentioning

confidence: 99%

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

2016

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The fast development of photoactivation for cancer treatment provides an efficient photo-therapeutic strategy for cancer treatment, but traditional photodynamic or photothermal therapy suffers from the critical issue of low in vivo penetration depth of tissues. As a non-invasive therapeutic modality, sonodynamic therapy (SDT) can break the depth barrier of photoactivation because ultrasound has an intrinsically high tissue-penetration performance. Micro/nanoparticles can efficiently augment the SDT efficiency based on nanobiotechnology. The state-of-art of the representative achievements on micro/nanoparticle-enhanced SDT is summarized, and specific functions of micro/nanoparticles for SDT are discussed, from the different viewpoints of ultrasound medicine, material science and nanobiotechnology. Emphasis is put on the relationship of structure/composition-SDT performance of micro/nanoparticle-based sonosensitizers. Three types of micro/nanoparticle-augmented SDT are discussed, including organic and inorganic sonosensitizers and micro/nanoparticle-based but sonosensitizer-free strategies to enhance the SDT outcome. SDT-based synergistic cancer therapy augmented by micro/nanoparticles and their biosafety are also included. Some urgent critical issues and potential developments of micro/nanoparticle-augmented SDT for efficient cancer treatment are addressed. It is highly expected that micro/nanoparticle-augmented SDT will be quickly developed as a new and efficient therapeutic modality which will find practical applications in cancer treatment. At the same time, fundamental disciplines regarding materials science, chemistry, medicine and nanotechnology will be advanced.

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Section: Nanoparticle‐augmented But Sonosensitizer‐free Sdtmentioning

confidence: 99%

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

2016

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“…Numerous strategies have been implemented to address the issue of detecting H 2 O 2 , including approaches based on proteins (24–27), nanotubes (28), hyperpolarization (29), ultrasound (30), mass spectrometry (MS) (31), and chemiluminescence (32). Of particular interest is a recent innovative enzyme-based detection method utilizing a variant of ascorbate peroxidase (APX).…”

Section: Chemical Tools For Detection Of Hydrogen Peroxide Sourcesmentioning

confidence: 99%

Chemical Approaches to Discovery and Study of Sources and Targets of Hydrogen Peroxide Redox Signaling Through NADPH Oxidase Proteins

Brewer¹,

García

Onak³

et al. 2015

Annu. Rev. Biochem.

177

124

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Hydrogen peroxide (H2O2) is a prime member of the reactive oxygen species (ROS) family of molecules produced during normal cell function and in response to various stimuli, but if left unchecked, it can inflict oxidative damage on all types of biological macromolecules and lead to cell death. In this context, a major source of H2O2 for redox signaling purposes is the NADPH oxidase (Nox) family of enzymes, which were classically studied for their roles in phagocytic immune response but have now been found to exist in virtually all mammalian cell types in various isoforms with distinct tissue and subcellular localizations. Downstream of this tightly regulated ROS generation, site-specific, reversible covalent modification of proteins, particularly oxidation of cysteine thiols to sulfenic acids, represents a prominent posttranslational modification akin to phosphorylation as an emerging molecular mechanism for transforming an oxidant signal into a dynamic biological response. We review two complementary types of chemical tools that enable (a) specific detection of H2O2 generated at its sources and (b) mapping of sulfenic acid post-translational modification targets that mediate its signaling functions, which can be used to study this important chemical signal in biological systems.

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“…Microjet, as a kind of bubble-driven microrobots, exhibits propulsion through catalytic reaction with surrounding fluids. These microrobots can be tracked indirectly by the generated tails of bubbles using ultrasound images [16], [17]. However, this method requires specific surrounding environments for catalytic reaction, and the reaction rate and time are hard to control.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Navigation of a Rotating Colloidal Swarm Using Ultrasound Images

Wang

Yang

et al. 2018

2018 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)

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Microrobots are considered as promising tools for biomedical applications. However, the imaging of them becomes challenges in order to be further applied on in vivo environments. Here we report the magnetic navigation of a paramagnetic nanoparticle-based swarm using ultrasound images. The swarm can be generated using simple rotating magnetic fields, resulting in a region containing particles with a high area density. Ultrasound images of the swarm shows a periodic changing of imaging contrast. The reason for such dynamic contrast has been analyzed and experimental results are presented. Moreover, this swarm exhibits enhanced ultrasound imaging in comparison to that formed by individual nanoparticles with a low area density, and the relationship between imaging contrast and area density is testified. Furthermore, the microrobotic swarm can be navigated near a solid surface at different velocities, and the imaging contrast show negligible changes. This method allows us to localize and navigate a microrobotic swarm with enhanced ultrasound imaging indicating a promising approach for imaging of microrobots.

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Toward in vivo detection of hydrogen peroxide with ultrasound molecular imaging

Cited by 95 publications

References 20 publications

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Chemical Approaches to Discovery and Study of Sources and Targets of Hydrogen Peroxide Redox Signaling Through NADPH Oxidase Proteins

Magnetic Navigation of a Rotating Colloidal Swarm Using Ultrasound Images

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