A hydrogel system containing molybdenum-based nanomaterials for wound healing

Lu, Yongzhou; Jia, Chuanlong; Gong, Chengchen; Wang, Han; Xiao, Qin; Guo, Jinxiao; Ni, Dalong; Xu, Nan

doi:10.1007/s12274-022-5255-9

Cited by 25 publications

(13 citation statements)

References 29 publications

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“…At the early stage of remodeling, granulation tissue and epidermal cells will appear hyperplasia and transition with the degradation of rMBG/Sr, and the number of capillaries in the damaged tissue will increase rapidly. 7,10 Fig. 9A shows the new capillaries of regenerated tissue in the wound site on days 7 and 14.…”

Section: In Vivo Wound Healing Assaymentioning

confidence: 99%

“…To this end, excellent biocompatibility, suitable microstructure and effective cell inductivity of the materials are the key requirements. 6–8 Furthermore, to facilitate wound healing, the materials should be able to induce rapid angiogenesis, as sufficient blood vessels are needed to effectively transport nutrients and oxygen, recruit tissue cells, and metabolize tissue waste. 9–11…”

Section: Introductionmentioning

confidence: 99%

“…To this end, excellent biocompatibility, suitable microstructure and effective cell inductivity of the materials are the key requirements. [6][7][8] Furthermore, to facilitate wound healing, the materials should be able to induce rapid angiogenesis, as sufficient blood vessels are needed to effectively transport nutrients and oxygen, recruit tissue cells, and metabolize tissue waste. [9][10][11] Currently, the most effective factors for promoting angiogenesis include vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), and Arg-Glu-Asp-Val (REDV Peptide).…”

Section: Introductionmentioning

confidence: 99%

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Strontium-doped mesoporous bioglass nanoparticles for enhanced wound healing with rapid vascularization

Fan

Razal

et al. 2023

J. Mater. Chem. B

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Section: In Vivo Wound Healing Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Strontium-doped mesoporous bioglass nanoparticles for enhanced wound healing with rapid vascularization

Fan

Razal

et al. 2023

J. Mater. Chem. B

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“…It has shown great potential in the field of wound healing by scavenging harmful ROS radicals and stimulating the expression of vascular factors and angiogenesis. [ 13 ]…”

Section: Introductionmentioning

confidence: 99%

“…Skin, the largest organ in the human body with various functions such as barrier, regulation, immunity, and metabolism, is the et al It has shown great potential in the field of wound healing by scavenging harmful ROS radicals and stimulating the expression of vascular factors and angiogenesis. [13] In the presence of ROS caused by radiation, tyrosine undergoes one-electron oxidation to generate tyrosine-based radicals, which can then generate various products through radical coupling reactions. [14] Therefore, based on the self-assembly peptide (KFKFEFEF), [15] we further exploited and optimized this self-assembly peptide by replacing phenylalanine (F) with tyrosine (Y).…”

Section: Introductionmentioning

confidence: 99%

Bio‐Inspired Antioxidant Heparin‐Mimetic Peptide Hydrogel for Radiation‐Induced Skin Injury Repair

Hao

Guo

et al. 2023

Adv Healthcare Materials

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Radiotherapy is one of the most important means of cancer treatment, however, radiation can also cause adverse reactions and even serious injuries to the skin. Radiation‐induced excess reactive oxygen species (ROS) production and inflammatory infiltration make skin wounds difficult to heal compared to normal skin injuries. Herein, an antioxidant heparin‐mimetic peptide hydrogel (K16, KYKYEYEYAGEGDSS‐4Sa) is designed for radiation‐induced skin injury (RISI) repair. First, the K16 peptide can self‐assemble into a hydrogel with a 3D mesh‐like porous nanofiber structure, which can provide certain physical support for skin repair like extracellular matrix (ECM). Then, K16 hydrogel not only scavenges ROS and prevents radiation damage to cellular DNA, but also promotes cell proliferation, migration, and angiogenesis. Meanwhile, 4‐sulfobenzoic acid (4Sa) modified at the N‐terminal end of the K16 peptide can adsorb inflammatory cytokines, thus acting to eliminate inflammation at the wound site. In vivo experiments showed that K16 hydrogel can inhibit early wound degradation, reduce inflammatory infiltration, and promote angiogenesis and collagen deposition, thus promoting wound healing. Therefore, the K16 hydrogel designed in this study has good potential for application in the field of radiation‐induced skin injury repair.

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e‐Bandage: Exploiting Smartphone as a Therapeutic Device for Cutaneous Wound Treatment

Yu,

Yi,

Lin

et al. 2024

Advanced Intelligent Systems

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Near‐infrared (NIR) radiation has demonstrated significant promise in skin tissue engineering and wound healing. However, the high cost and operational complexity associated with current specialized apparatuses have hindered their practical household use. In response to these issues, a flexible, battery‐free, wireless sensor–actuator NIR therapy system, offering real‐time physiological monitoring and active treatment to cutaneous wounds, is developed. The wound management system can be wirelessly powered, and transmits data to any near‐field communication‐compatible smartphone. The therapeutic prowess of our system for wound closure is computationally and experimentally demonstrated by promoting epithelial migration and modulating inflammation. Moreover, a novel feature is reported: the smartphone‐enabled system can precisely predict the wound stage via a temperature sensor pair, which can provide an effective timely intervention strategy for NIR wound therapy. Studies based on rat wound model successfully confirm the efficacy of the proposed strategy, showcasing a remarkable 30% enhancement in wound closure compared to control groups. The user‐friendly, effective wound management platform promises a revolutionary step toward accessible and efficient at‐home wound care.

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A hydrogel system containing molybdenum-based nanomaterials for wound healing

Cited by 25 publications

References 29 publications

Strontium-doped mesoporous bioglass nanoparticles for enhanced wound healing with rapid vascularization

Strontium-doped mesoporous bioglass nanoparticles for enhanced wound healing with rapid vascularization

Bio‐Inspired Antioxidant Heparin‐Mimetic Peptide Hydrogel for Radiation‐Induced Skin Injury Repair

e‐Bandage: Exploiting Smartphone as a Therapeutic Device for Cutaneous Wound Treatment

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