A hydrogel/fiber scaffold based on silk fibroin/oxidized pectin with sustainable release of vancomycin hydrochloride

Ahadi, Fereshteh; Khorshidi, Sajedeh; Karkhaneh, Akbar

doi:10.1016/j.eurpolymj.2019.06.001

Cited by 59 publications

(28 citation statements)

References 26 publications

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“…The modulus of formulation with equal content of functionalized pectin and fibroin was substantially higher than fibroin ( p < 0.05) because of formation of strong chemical crosslinking between pectin and fibroin chains in blended composition instead of weak interactions between fibroin macromolecules in neat fibroin. The obtained compressive modulus values for hydrogels were in line with the values reported by other pertinent researches …”

Section: Resultssupporting

confidence: 91%

“…The crosslink density values were almost similar with those reported by Ahadi et al . for oxidized pectin/fibroin sample due to the same concentration of precursor solution and the same crosslinking mechanism.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, the effect of composition on hydrogel rheology and mechanics has not been evaluated. Ahadi et al . have designed a drug‐loaded hydrogel/fiber assembly in which the hydrogel was a covalently network of oxidized pectin and fibroin.…”

Section: Introductionmentioning

confidence: 99%

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High‐strength functionalized pectin/fibroin hydrogel with tunable properties: A structure–property relationship study

Khorshidi

Karkhaneh

Bonakdar

et al. 2019

J of Applied Polymer Sci

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Hydrogels possessing high mechanical strength and well-controlled properties are of utmost interest in bone tissue engineering. In the current study, a strong self-crosslinked hydrogel with variable properties has been developed from a combinatory composition of functionalized pectin and silk fibroin. Pectin chains underwent partial oxidation to be decorated with aldehyde functionalities. Later on, functionalized polysaccharide and protein were blended with different ratios, and corresponding variations in crystalline structure as well as in morphological, mechanical, and rheological properties have been monitored. Some theories have been used to better perceive the relation between blending ratio and hydrogel properties. Avrami equation based on time sweep rheological analysis elucidated that in sample with equivalent ratio of oxidized pectin and fibroin, the crystallization was highly delayed due to dominance of Schiff's base reaction. The Herschel-Bulkley model based on flow curve rheology test corroborated that aforesaid composition revealed the most noticeable shear thinning behavior and accordingly the strongest crosslinked network. Finally, rubber elastic theory based on dynamic mechanical analysis implied that said formulation possessed the highest crosslinking density due to higher availability of aldehyde to amine functionalities. Moreover, cell culture studies proved that P50 F50 sample prevailed over other compositions with respect to cell viability and function.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

High‐strength functionalized pectin/fibroin hydrogel with tunable properties: A structure–property relationship study

Khorshidi

Karkhaneh

Bonakdar

et al. 2019

J of Applied Polymer Sci

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“…Recently, research on fiber–hydrogel composites has increased significantly. These scaffolding systems have been investigated for a range of applications, including wound healing [ 206 ], regeneration of corneal stroma [ 184 ], nucleus pulposus regeneration [ 201 ], bone tissue engineering [ 207 ], antibiotic delivery [ 208 ] and heart valve tissue engineering [ 209 ]. Scaffolds with an architecture that mimics native ECM and allows cell infiltration and differentiation has emerged as a prospective solution for the treatment of various health complications.…”

Section: Applications Of Fiber–hydrogel Compositesmentioning

confidence: 99%

Recent Advances in Fiber–Hydrogel Composites for Wound Healing and Drug Delivery Systems

2021

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In the last decades, much research has been done to fasten wound healing and target-direct drug delivery. Hydrogel-based scaffolds have been a recurrent solution in both cases, with some reaching already the market, even though their mechanical stability remains a challenge. To overcome this limitation, reinforcement of hydrogels with fibers has been explored. The structural resemblance of fiber–hydrogel composites to natural tissues has been a driving force for the optimization and exploration of these systems in biomedicine. Indeed, the combination of hydrogel-forming techniques and fiber spinning approaches has been crucial in the development of scaffolding systems with improved mechanical strength and medicinal properties. In this review, a comprehensive overview of the recently developed fiber–hydrogel composite strategies for wound healing and drug delivery is provided. The methodologies employed in fiber and hydrogel formation are also highlighted, together with the most compatible polymer combinations, as well as drug incorporation approaches creating stimuli-sensitive and triggered drug release towards an enhanced host response.

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“…Electrospun nanofibers are fascinating carries for CPO and also persuasive tissue engineering scaffolds. 19 CPO nanoparticles can be simply mixed with electrospun solution and be loaded into resulting fibers. Furthermore, a natural extracellular matrix is composed of protein fibers elongated into a hydrogel background.…”

Section: Introductionmentioning

confidence: 99%

Oxygen-releasing nanofibers for breathable bone tissue engineering application

2020

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Oxygen is a vital molecule for cell and tissue processes. Electrospun fibers have been extensively used as drug loading carriers due to possibility of well control over drug release with modulating fiber properties. However, they have not been used as depots for oxygen release. In the present study, an oxygen-releasing nanofibrous scaffold has been developed by electrospinning of polylactic acid/nano-calcium peroxide suspension with different polylactic acid concentrations (6.5 and 13% w/v). The electrospun fibers with calcium peroxide cargo provided oxygen content of 30–94 mmHg in a period of 14 days which lies well within the oxygen level of osseous tissue. The release profile of 13% polylactic acid fibers was different with that of 6.5% fibers with respects to the initial content of released oxygen and the release rate. Not only did 13% fibers supply oxygen with a slower rate, but also they resulted in a lower burst release of oxygen. Cell culture studies in hypoxia corroborated that 13% polylactic acid fibers better preserve cell viability comparing 6.5% counterparts as perceived by MTT assay. Moreover, they endowed more favored milieu for adherence, arrangement and migration of mesenchymal stem cells as confirmed by microscopy images. The oxygen-releasing fibers equally affected alkaline phosphatase, osteocalcin, and calcium deposition by mesenchymal stem cells most likely due to interplay between topographical and metabolic cues offered by 6.5 and 13% formulations.

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A hydrogel/fiber scaffold based on silk fibroin/oxidized pectin with sustainable release of vancomycin hydrochloride

Cited by 59 publications

References 26 publications

High‐strength functionalized pectin/fibroin hydrogel with tunable properties: A structure–property relationship study

High‐strength functionalized pectin/fibroin hydrogel with tunable properties: A structure–property relationship study

Recent Advances in Fiber–Hydrogel Composites for Wound Healing and Drug Delivery Systems

Oxygen-releasing nanofibers for breathable bone tissue engineering application

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