A hydrogel directly assembled from a copper metal–organic polyhedron for antimicrobial application

Qin, Yu; Chen, Linlin; Pu, Wei; Liu, Peng; Liu, Shixi; Li, Yuan; Liu, Xiaolan; Lu, Zhixiang; Zheng, Liyan; Cao, Qiue

doi:10.1039/c8cc09000a

Cited by 26 publications

(31 citation statements)

References 48 publications

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“…After the nutrient agar concreting, the Petri dish was incubated for 24 h at 37° C and the CFUs were counted. The antibacterial rate was evaluated by the following formula: Antibacterial rate [14] = (CFUs in the control group − CFUs in the experiment group)/CFUs in the control group × 100%.…”

Section: Methodsmentioning

confidence: 99%

A dual PMMA/calcium sulfate carrier of vancomycin is more effective than PMMA‐vancomycin at inhibiting Staphylococcus aureus growth in vitro

et al. 2020

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Both antibiotic‐impregnated poly(methyl acrylate, methyl methacrylate) (PMMA) and antibiotic‐impregnated calcium sulfate have been successfully used as local antibiotic delivery vehicles for the management of chronic osteomyelitis. Here, we examined the antibiotic elution characteristics and antibacterial properties of a composite drug delivery system consisting of PMMA/calcium sulfate carrying vancomycin (dual carrier‐v) against Staphylococcus aureus, with PMMA loaded with vancomycin (PMMA‐v) as a control. Vancomycin gradually degraded from dual carrier‐v and PMMA‐v up to about 8 and 6 weeks, respectively. At different elution time points, the inhibition zones of the dual carrier‐v were larger than the inhibition zones of the PMMA‐v (P < 0.05). The colony inhibition rate of the dual carrier‐v was 95.57%, whereas it was 77.87% for PMMA‐v. Scanning electron microscopy was used to demonstrate biofilm formation on the surface of plates treated with vancomycin‐unloaded PMMA, whereas there was no biofilm formation on the surface of plates treated with dual carrier‐v or PMMA‐v. The dual carrier‐v was more effective at antibacterial adhesion at each time point after immersion in simulated body fluid as compared with PMMA‐v (P < 0.05). In conclusion, our results suggest that the dual carrier‐v can release higher concentrations of antibiotics and inhibit bacteria growth more effectively in vitro as compared with PMMA‐v. The dual carrier‐v thus may have potential as an alternative strategy for osteomyelitis management.

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Section: Methodsmentioning

confidence: 99%

A dual PMMA/calcium sulfate carrier of vancomycin is more effective than PMMA‐vancomycin at inhibiting Staphylococcus aureus growth in vitro

et al. 2020

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“…[ 142–148 ] Especially, Cu‐involved components are the desirable antimicrobial agents on combating versatile bacteria with some underlying mechanisms including the generation of ROS, released metal‐ion toxicity and the potential mechanical destruction of bacterial cell walls/membranes. [ 149–157 ]…”

Section: Cu‐involved Nanoagents For Antibacterial Applicationsmentioning

confidence: 99%

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

et al. 2020

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As an essential trace element in the human body, transitional metal copper (Cu) ions are the bioactive components within the body featuring dedicated biological effects such as promoting angiogenesis and influencing lipid/glucose metabolism. The recent substantial advances of nanotechnology and nanomedicine promote the emerging of distinctive Cu‐involved biomaterial nanoplatforms with intriguing theranostic performances in biomedicine, which are originated from the biological effects of Cu species and the physiochemical attributes of Cu‐composed nanoparticles. Based on the very‐recent significant progresses of Cu‐involved nanotheranostics, this work highlights and discusses the principles, progresses, and prospects on the elaborate design and rational construction of Cu‐composed functional nanoplatforms for a diverse array of biomedical applications, including photonic nanomedicine, catalytic nanotherapeutics, antibacteria, accelerated tissue regeneration, and bioimaging. The engineering of Cu‐based nanocomposites for synergistic nanotherapeutics is also exemplified, followed by revealing their intrinsic biological effects and biosafety for revolutionizing their clinical translation. Finally, the underlying critical concerns, unresolved hurdles, and future prospects on their clinical uses are analyzed and an outlook is provided. By entering the “Copper Age,” these Cu‐involved nanotherapeutic modalities are expected to find more broad biomedical applications in preclinical and clinical phases, despite the current research and developments still being in infancy.

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“…Metal-organic polyhedra (MOPs), a class of discrete coordination cages with well-defined internal cavities, have emerged as microporous building blocks for the construction of extended porous architectures due to their good solubility and designable outer periphery available for further connection. [1][2] By crosslinking MOPs with ditopic linkers [3][4] or tuning the noncovalent interaction between them (hydrogen bonding, [5][6] electrostatic interaction [7][8] and host-guest interaction, [9][10] for instance), various multidimensional assemblies are synthesized, ranging from crystalline porous solids like metal-organic frameworks (MOFs) 11 to amorphous soft materials such as films [12][13] or gels. [14][15][16] Considering practical applications, the latter has attracted increasing interests because of their potentials for realizing processable microporous materials.…”

Section: Introductionmentioning

confidence: 99%

Control of extrinsic porosities in linked metal-organic polyhedra gels by imparting coordination-driven self-assembly with electrostatic repulsion

Wang

Aoyama

Sanchez-Gonzales

et al. 2022

Preprint

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The linkage of metal-organic polyhedra (MOPs) for the synthesis of porous soft materials is one of the promising strategies to combine processability with permanent porosity. Compared to the defined internal cavity of MOPs, it is still difficult to control the extrinsic porosities generated between crosslinked MOPs because of their random arrangements in their networks. Herein, we report a method to form linked MOP gels with controllable extrinsic porosities by introducing negative charges on the surface of MOPs that facilitates electrostatic repulsion between them. A hydrophilic rhodium-based cuboctahedral MOP (OHRhMOP) with 24 hydroxyl groups on its outer periphery can be controllably deprotonated to impart the MOP with tunable electrostatic repulsion in solution. This electrostatic repulsion between MOPs stabilizes the kinetically trapped state, in which a MOP is coordinated with various bisimidazole linkers in a monodentate fashion at a controllable link-er/MOP ratio. The heating of the kinetically trapped molecules leads to the formation of gels with similar colloidal networks but different extrinsic porosity. This strategy allows us to design the molecular-level networks and the resulting porosities even in the amorphous state.

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A hydrogel directly assembled from a copper metal–organic polyhedron for antimicrobial application

Abstract: A hydrogel was directly assembled from a Cu-MOP by a facile procedure without adding any polymers for the first time, and it exhibited excellent antibacterial activity towards both Gram-negative and Gram-positive bacteria.

Cited by 26 publications

References 48 publications

A dual PMMA/calcium sulfate carrier of vancomycin is more effective than PMMA‐vancomycin at inhibiting Staphylococcus aureus growth in vitro

A dual PMMA/calcium sulfate carrier of vancomycin is more effective than PMMA‐vancomycin at inhibiting Staphylococcus aureus growth in vitro

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

Control of extrinsic porosities in linked metal-organic polyhedra gels by imparting coordination-driven self-assembly with electrostatic repulsion

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