A Hybrid Nanomaterial for the Controlled Generation of Free Radicals and Oxidative Destruction of Hypoxic Cancer Cells

Shen, Song; Zhu, Chunlei; Huo, Da; Yang, Miaoxin; Xue, Jiajia; Xia, Younan

doi:10.1002/ange.201702898

Cited by 37 publications

(33 citation statements)

References 28 publications

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“…However, the relatively low tissue-penetrating depth of light in biological tissue still remains as an intrinsic shortcoming 10 – 12 . More troublesome, the reliance of PDT on molecular oxygen limits its effectiveness in hypoxic environments, including many solid tumors 13 – 15 . Alternatively, sonodynamic therapy (SDT) that comprises ultrasound and sonosensitzer as ROS generator has been developed recently and witnessed some exciting results 16 , 17 .…”

Section: Introductionmentioning

confidence: 99%

Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors

et al. 2018

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Reactive oxygen species (ROS)-induced apoptosis is a promising treatment strategy for malignant neoplasms. However, current systems are highly dependent on oxygen status and/or external stimuli to generate ROS, which greatly limit their therapeutic efficacy particularly in hypoxic tumors. Herein, we develop a biomimetic nanoflower based on self-assembly of nanozymes that can catalyze a cascade of intracellular biochemical reactions to produce ROS in both normoxic and hypoxic conditions without any external stimuli. In our formulation, PtCo nanoparticles are firstly synthesized and used to direct the growth of MnO2. By adjusting the ratio of reactants, highly-ordered MnO2@PtCo nanoflowers with excellent catalytic efficiency are obtained, where PtCo behaves as oxidase mimic and MnO2 functions as catalase mimic. In this way, the well-defined MnO2@PtCo nanoflowers not only can relieve hypoxic condition but also induce cell apoptosis significantly through ROS-mediated mechanism, thereby resulting in remarkable and specific inhibition of tumor growth.

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Section: Introductionmentioning

confidence: 99%

Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors

et al. 2018

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“…Both lauric and stearic acids have absolute biocompatibility since they are derived from natural fats. This PCM can serve as a gating material for controlling the generation and release of free radicals to eradicate cancer cells . It can also be adopted to reconstitute the core of low‐density lipoprotein to realize metabolism‐triggered drug release, and furthermore, be constructed into smart nanoparticles for intracellular drug delivery .…”

Section: Introductionmentioning

confidence: 99%

Integration of Phase‐Change Materials with Electrospun Fibers for Promoting Neurite Outgrowth under Controlled Release

Xue

Zhu

et al. 2018

Adv Funct Materials

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We report a temperature-regulated system for the controlled release of nerve growth factor (NGF) to promote neurite outgrowth. The system is based upon microparticles fabricated using coaxial electrospray, with the outer solution containing a phase-change material (PCM) and the inner solution encompassing payload(s). When the temperature is kept below the melting point of the PCM, there is no release due to the extremely slow diffusion through a solid matrix. Upon increasing the temperature to slightly pass the melting point, the encapsulated payload(s) can be readily released from the melted PCM. By leveraging the reversibility of the phase transition, the payload(s) can be released in a pulsatile mode through on/off heating cycles. The controlled release system is evaluated for potential use in neural tissue engineering by sandwiching the microparticles, co-loaded with NGF and a near-infrared dye, between two layers of electrospun fibers to form a tri-layer construct. Upon photothermal heating with a near-infrared laser, the NGF is released with well-preserved bioactivity to promote neurite outgrowth. By choosing different combinations of PCM, biological effector, and scaffolding material, this controlled release system can be applied to a wide variety of biomedical applications.

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“…[24] In ac ompletely different application, fatty acids have been explored as anew class of gating materials for controlled release by leveraging their welldefined, sharp melting points. [25][26][27][28][29] In principle,s olid microparticles of fatty acids can be used as am ulti-functional platform to present topographic guidance while offering achemical cue and serving as agating material for controlled release.…”

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confidence: 99%

“…Herein, we utilized electrospray to fabricate solid microparticles from amixture of lauric acid and stearic acid, which was formulated with asharp melting point at 39 8 8Ctoensure structural integrity when cultured with cells. [25][26][27] We varied the densities of the microparticles on glass slides to construct substrates with controllable topographical cues to optimize the outgrowth of neurites from PC12 cells.W ealso examined the influences of the microparticles on neurite outgrowth by benchmarking against free fatty acids at different concentrations.F urthermore,w ed eposited the microparticles on uniaxially aligned, electrospun microfibers at an optimal density to direct the outgrowth of neurites from both PC12 multicellular spheroids and chick embryonic dorsal root ganglia (DRG) bodies.…”

mentioning

confidence: 99%

“…[32] In addition, known for their reversible solid-liquid phase transition in response to temperature variation, fatty acids have been used as ac lass of thermosensitive materials for the controlled release of various bioactive agents. [25][26][27][28][29] This unique capability can be combined with various types of growth factors to further enhance neurite outgrowth.…”

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confidence: 99%

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Promoting the Outgrowth of Neurites on Electrospun Microfibers by Functionalization with Electrosprayed Microparticles of Fatty Acids

Xue

et al. 2019

Angewandte Chemie

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Controlling the outgrowth of neurites is important for enhancing the repair of injured nerves and understanding the development of nervous systems.Herein we report asimple strategy for enhancing the outgrowth of neurites through aunique integration of topographical guidance and achemical cue.W eu se electrospray to easily functionalize the surface of as ubstrate with microparticles of natural fatty acids at ac ontrollable density.T hrough as ynergistic effect from the surface roughness arising from the microparticles and the chemical cue offered by the fatty acids,t he outgrowth of neurites from PC12 cells is greatly enhanced. We also functionalize the surfaces of uniaxially aligned, electrospun microfibers with the microparticles and further demonstrate that the substrates can guide and enhance directional outgrowth of neurites from both PC12 multicellular spheroids and chick embryonic dorsal root ganglia bodies.

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A Hybrid Nanomaterial for the Controlled Generation of Free Radicals and Oxidative Destruction of Hypoxic Cancer Cells

Cited by 37 publications

References 28 publications

Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors

Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors

Integration of Phase‐Change Materials with Electrospun Fibers for Promoting Neurite Outgrowth under Controlled Release

Promoting the Outgrowth of Neurites on Electrospun Microfibers by Functionalization with Electrosprayed Microparticles of Fatty Acids

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