Promoting the Outgrowth of Neurites on Electrospun Microfibers by Functionalization with Electrosprayed Microparticles of Fatty Acids

Abstract

Controlling the outgrowth of neurites is important for enhancing the repair of injured nerves and understanding the development of nervous systems.Herein we report asimple strategy for enhancing the outgrowth of neurites through aunique integration of topographical guidance and achemical cue.W eu se electrospray to easily functionalize the surface of as ubstrate with microparticles of natural fatty acids at ac ontrollable density.T hrough as ynergistic effect from the surface roughness arising from the microparticles and the chemical cue offered by the fatty acids,t he outgrowth of neurites from PC12 cells is greatly enhanced. We also functionalize the surfaces of uniaxially aligned, electrospun microfibers with the microparticles and further demonstrate that the substrates can guide and enhance directional outgrowth of neurites from both PC12 multicellular spheroids and chick embryonic dorsal root ganglia bodies.

Accelerated Outgrowth of Neurites on Graphene Oxide-Based Hybrid Electrospun Fibro-Porous Polymeric Substrates

“…GO films on the nanocomposite scaffold GOKAF thus provided a suitable substrate for neurite development and outgrowth. In addition to this, the presence of wrinkled GO thin films may also offer a soft tissue-like ambient to neurites for stretching over their surface and hence may induce a mechanical stimulus to develop longer extensions. , …”

Encapsulation of a Phase‐Change Material in Nanocapsules with a Well‐Defined Hole in the Wall for the Controlled Release of Drugs

“…[2] Among various types of PCMs,natural fatty acids,acritical structural component of cells and important dietary source of energy for animals,are particularly attractive owing to their biocompatibility,b iodegradability,d iversity,a bundance,a nd low cost. [3] However,t he nanoparticles made of fatty acids usually have poor dispersibility in an aqueous medium. They tend to aggregate into larger particles and then float on the surface of an aqueous solution.…”

Encapsulation of a Phase‐Change Material in Nanocapsules with a Well‐Defined Hole in the Wall for the Controlled Release of Drugs

“…[1] Thep ayloads trapped inside solid PCM can be swiftly released upon melting (i.e., solid-to-liquid phase transition) in response to atemperature rise. [3] However,t he nanoparticles made of fatty acids usually have poor dispersibility in an aqueous medium. [3] However,t he nanoparticles made of fatty acids usually have poor dispersibility in an aqueous medium.…”