A hyaluronic acid/PVA electrospun coating on 3D printed PLA scaffold for orthopedic application

Farsi, Mina; Asefnejad, Azadeh; Baharifar, Hadi

doi:10.1007/s40204-022-00180-z

Cited by 27 publications

(7 citation statements)

References 40 publications

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“…It presents an ideal microenvironment suitable for cartilage differentiation and growth, thus proving its application in cartilage tissue engineering. Similarly, Farsi et al 130 fabricated PLA scaffolds via FDM 3D printing and coated them with PVA/HA nanofibers. The scaffold exhibited hydrophilicity, owing to the presence of PVA and hyaluronic acid.…”

Section: Combinational Approach: 3d Printing and Electrospinningmentioning

confidence: 99%

Integration of 3D Printing–Coelectrospinning: Concept Shifting in Biomedical Applications

et al. 2023

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Porous structures with sizes between the submicrometer and nanometer scales can be produced using efficient and adaptable electrospinning technology. However, to approximate desirable structures, the construction lacks mechanical sophistication and conformance and requires three-dimensional solitary or multifunctional structures. The diversity of high-performance polymers and blends has enabled the creation of several porous structural conformations for applications in advanced materials science, particularly in biomedicine. Two promising technologies can be combined, such as electrospinning with 3D printing or additive manufacturing, thereby providing a straightforward yet flexible technique for digitally controlled shape-morphing fabrication. The hierarchical integration of configurations is used to imprint complex shapes and patterns onto mesostructured, stimulus-responsive electrospun fabrics. This technique controls the internal stresses caused by the swelling/contraction mismatch in the in-plane and interlayer regions, which, in turn, controls the morphological characteristics of the electrospun membranes. Major innovations in 3D printing, along with additive manufacturing, have led to the production of materials and scaffold systems for tactile and wearable sensors, filtration structures, sensors for structural health monitoring, tissue engineering, biomedical scaffolds, and optical patterning. This review discusses the synergy between 3D printing and electrospinning as a constituent of specific microfabrication methods for quick structural prototypes that are expected to advance into next-generation constructs. Furthermore, individual techniques, their process parameters, and how the fabricated novel structures are applied holistically in the biomedical field have never been discussed in the literature. In summary, this review offers novel insights into the use of electrospinning and 3D printing as well as their integration for cutting-edge applications in the biomedical field.

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Section: Combinational Approach: 3d Printing and Electrospinningmentioning

confidence: 99%

Integration of 3D Printing–Coelectrospinning: Concept Shifting in Biomedical Applications

et al. 2023

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“…The microstructure of the scaffolds mimicked the structure of the ECM, with a wrinkled inner surface and porous hierarchical structure, which effectively promoted cell proliferation and osteogenic differentiation. Farsi et al [ 175 ] used fused-deposition modeling to prepare PLA scaffolds for cartilage applications and then electrostatically spin-coated the scaffolds with polyvinyl alcohol (PVA) and HA fibers. The elastic moduli of the PVA/PLA and PLA/PVA/HA scaffolds were increased to 18.31 ± 0.29 and 19.25 ± 0.38 MPa, respectively, by electrostatic spin-coating.…”

Section: Applications Of Ha Bioinksmentioning

confidence: 99%

3D printed scaffolds based on hyaluronic acid bioinks for tissue engineering: a review

Chen,

Xue,

Zeng

et al. 2023

Biomater Res

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Hyaluronic acid (HA) is widely distributed in human connective tissue, and its unique biological and physicochemical properties and ability to facilitate biological structure repair make it a promising candidate for three-dimensional (3D) bioprinting in the field of tissue regeneration and biomedical engineering. Moreover, HA is an ideal raw material for bioinks in tissue engineering because of its histocompatibility, non-immunogenicity, biodegradability, anti-inflammatory properties, anti-angiogenic properties, and modifiability. Tissue engineering is a multidisciplinary field focusing on in vitro reconstructions of mammalian tissues, such as cartilage tissue engineering, neural tissue engineering, skin tissue engineering, and other areas that require further clinical applications. In this review, we first describe the modification methods, cross-linking methods, and bioprinting strategies for HA and its derivatives as bioinks and then critically discuss the strengths, shortcomings, and feasibility of each method. Subsequently, we reviewed the practical clinical applications and outcomes of HA bioink in 3D bioprinting. Finally, we describe the challenges and opportunities in the development of HA bioink to provide further research references and insights. Graphical Abstract

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“…Studies have shown that scaffolds based on hyaluronic acid have an obvious bone‐inducing effect in the process of cartilage repair and can significantly promote the repair of defective cartilage, which is a good candidate material in tissue engineering cartilage repair. Farsi et al 129 fabricated the PLA/PVA/HLA scaffolds through the FDM technique. Although the addition of HLA slightly decreases the mechanical properties of the scaffolds, it apparently reinforces the biocompatibility and cell adhesion of the composite, which is confirmed by the cells' behavior.…”

Section: D Printed Degradable Pla‐based Bone Repair Scaffolds (Classi...mentioning

confidence: 99%

Recent progress in 3D printing degradable polylactic acid‐based bone repair scaffold for the application of cancellous bone defect

Lin

et al. 2022

MedComm – Biomaterials and Applications

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Large size bone defects have become a growing clinical challenge. Cancellous bone, which has the highest volume ratio, the fastest replacement rate, and interconnected porous structure, plays a major role in bone repairing. Considering the structure and composition of cancellous bone, building a bionic 3D scaffold via customized‐3D printing technology is the key to solving the problem. As the earliest degradable medical polymer material approved by Food and Drug Administration, polylactic acid has been proved to have excellent biosafety and can be copolymerized or blended with other synthetic polymers, natural polymers, and inorganic materials to improve its performance to better meet clinical applications. A series of biodegradable bone repair scaffolds based on polylactic acid composites and 3D printing technology are developed to achieve large bone defects. Here, we review the composition and structure of cancellous bone, highlighting the relationship to the requirements of bone repair scaffolds. The different types of polylactic‐acid‐based materials applied in 3D printing technology are described, emphasizing the connection between materials, preparation methods, and applications.

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A hyaluronic acid/PVA electrospun coating on 3D printed PLA scaffold for orthopedic application

Cited by 27 publications

References 40 publications

Integration of 3D Printing–Coelectrospinning: Concept Shifting in Biomedical Applications

Integration of 3D Printing–Coelectrospinning: Concept Shifting in Biomedical Applications

3D printed scaffolds based on hyaluronic acid bioinks for tissue engineering: a review

Recent progress in 3D printing degradable polylactic acid‐based bone repair scaffold for the application of cancellous bone defect

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