A hyaluronic acid/platelet-rich plasma hydrogel containing MnO2 nanozymes efficiently alleviates osteoarthritis in vivo

Zhou, Tong; Ran, Jisheng; Xu, Pinghong; Shen, Liren; He, Yuzhe; Ye, Juan; Wu, Lidong; Gao, Changyou

doi:10.1016/j.carbpol.2022.119667

Cited by 61 publications

(43 citation statements)

References 55 publications

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“…Zhou et al. also created a MnO 2 ‐encapsulated hydrogel by dispersing bovine serum albumin (BSA)‐MnO 2 nanoparticles (BMNPs) into a hyaluronic acid (HA)/platelet‐rich plasma (PRP) gel network [ 22 ] ( Figure ). The Schiff base bonds in the HA/PRP hydrogel then enabled it to release BM NPS and growth factors in response to the acidic microenvironment.…”

Section: Drug Delivery Nanoplatforms That Respond To the Endogenous P...mentioning

confidence: 99%

Stimulus‐Responsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy

Jiang

Zhang

2023

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Fundamentally degenerative, OA represents a considerably negative impact on the quality of life. [1,2] With an increasingly aging global population, greater numbers of OA patients are representing a clear increase in economic and societal burden. OA is primarily characterized by the degeneration or deterioration of articular cartilage. [3] More specifically, as a result of the excessive recruitment of inflammatory cells at the joint site, [4] matrix metalloproteinase (MMP) [5] and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) [6] are overexpressed during the development of OA, which leads to the destruction of the collagen II network and glycosaminoglycan (GAG). Articular cartilage dysfunction and degradation then eventually result, often presenting with permanent pathologic alterations to the entire joint.Current pharmacological treatments, (primarily focused on pain relief and antiinflammation), and/or surgery, (including microfracture surgery and joint replacement), are the most conventional therapeutic approaches for OA. [1,7] There are several disadvantages to these conventional approaches. Whilst microfracture surgery provides a measure of relief and functional recovery of the smaller-scale joint defects through the local generation of fibrocartilage from bone marrow obtained from the subchondral bone, due to the lower abrasion-resistance ability of fibrocartilage this method is often unsuitable to provide long-term relief, or for situations where large-scale defects have occurred. [8] A number of clinical strategies of joint replacement, including osteochondral autografts or allografts, are also limited by the restricted availability of donor grafts or by complications requiring secondary surgery. [9] Along with the continued development of surgical treatments, more advanced therapeutic methods have also been developed for OA surgery. These include ACI (autologous chondrocyte implantation) and MACI (matrix-induced autologous chondrocyte implantation). However, for ACI, the viability and loss of chondrocytes during the planting procedure seem to be an unavoidable problem. MACI was developed as a potential solution to this, where the in vitro use of a biodegradable (collagen matrix membrane) material as a temporary scaffold for the pre-plantation of chondrocytes could effectively lessen the loss of cells during the process of transplantation. However, for patients of more advanced ages or with too large an area of injury to the cartilage, MACI remains an unsuitable therapeutic approach.Osteoarthritis (OA) is one of the most prevalent age-related degenerative diseases. With an increasingly aging global population, greater numbers of OA patients are providing clear economic and societal burdens. Surgical and pharmacological treatments are the most common and conventional therapeutic strategies for OA, but often fall considerably short of desired or optimal outcomes. With the development of stimulus-responsive nanoplatforms has come the potential for improved therapeutic strategies for...

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Section: Drug Delivery Nanoplatforms That Respond To the Endogenous P...mentioning

confidence: 99%

Stimulus‐Responsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy

Jiang

Zhang

2023

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“… Hydrogels Components Physicochemical properties Biofunctions Ref. HA-ADH/d-AHA HA, adipic dihydrazide, dialdehyde HA Shear-responsive; boundary lubricated; anti-inflammatory; injectable; self-healing; controlled-release of bioactive molecules Reducing friction; alleviating the progression of OA; inhibiting inflammation; protecting chondrocytes [ 141 , 142 ] HA-ADH/dextran HA, adipic dihydrazide, dialdehyde dextran ROS depletion, sustainable drug release; viscosupplementation Inhibiting inflammation; alleviating the progression of OA; protecting cartilage [ 143 ] HA-ADH/pectin HA, adipic dihydrazide, oligopeptide-grafted dialdehyde pectin Short gel times; controllable mechanical properties and degradation capacity Providing a suitable microenvironment for the phenotype of chondrocytes and chondrogenesis [ 144 ] HA-Fur/CS-Mal/ACS/ADH Methylfuran-modified HA, maleimide-modified chondroitin sulfate, adipic dihydrazide, dialdehyde chondroitin sulfate Double-network; controllable viscoelasticity and stress relaxation; good processability; self-healing ability; high swelling capacity and stability Negligible inflammatory response [ 145 ] HA-Ad/ β -CD-Ac HA, adamantane, monoacrylated β -cyclodextrin Good self-healing properties, compressibility; sustained release of TGF- β 1 Rapidly integrating with the defect tissue; promoting the chondrogenesis of MSCs and cartilage regeneration [ 146 ] HA-Ad/ β -CD-SH/HA-Mal HA, adamantane, thiolated β -cyclodextrin, maleimide Tunable viscoelasticity Maintaining 3D spreading and intracellular interactions of encapsulated MSCs [ 147 ] HA- β -CD/PAA-Fer HA, β -cyclodextrin, ferrocene, polyacrylic acid Magnetic navigation; controlled release of glutathione Promoting the columnar arrangement of chondrocytes and the repair of cartilage damage [ 148 ] HA-CB [ 6 ]/HA-PA HA, cucurbit [ …”

Section: Hydrazide Ha-based Hydrogels For Cartilage Tissue Engineeringmentioning

confidence: 99%

“…further used an HA-ADH/d-AHA hydrogel to load bovine serum albumin-modified dioxide manganese nanoparticles and PRP. Biological experiments have indicated that the hydrogel can significantly increase the proliferation of chondrocytes and alleviate OA in vivo by inhibiting inflammation and protecting chondrocytes from oxidative stress [ 142 ]. Zhou et al.…”

Section: Hydrazide Ha-based Hydrogels For Cartilage Tissue Engineeringmentioning

confidence: 99%

Designing functional hyaluronic acid-based hydrogels for cartilage tissue engineering

Wang

Deng

Guo

et al. 2022

Materials Today Bio

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“…MNMs may also act on cell energy metabolism pathways, inflammatory cytokine pathways, and autophagic and proapoptotic signaling to exert multiple effects in the treatment of complicated diseases (such as systemic metabolic disorders and neurodegenerative illnesses). [84,87,[156][157][158][159][160][161] The pathogenesis of type 2 diabetes features macrophage infiltration and proinflammatory cytokine release that cause local islet inflammation and β-cell apoptosis as well as insulin resistance in peripheral tissues, resulting in hyperglycemia and multiple complications. [162][163][164][165][166] Fe 3 O 4 NPs reduced macrophage-induced oxidative stress of pancreatic islets to reduce the secretion of IL-1β through its CAT-like activity, thus inhibiting β-cell apoptosis.…”

Section: Treatment In Other Fieldsmentioning

confidence: 99%

Metal‐Based Nanozymes with Multienzyme‐Like Activities as Therapeutic Candidates: Applications, Mechanisms, and Optimization Strategy

Dai

Xiong

et al. 2022

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manganese(III) oxide (Mn 2 O 3 ), and Prussian blue nanozyme (PBzyme), etc., have multienzyme-like activities, which enable either the efficient production of reactive oxygen species (ROS) to kill tumor cells and bacteria, or the clearance of ROS to reduce oxidative stress and inflammation. [9][10][11][12][13][14] These metal-based nanozymes display multiple antitumor, anti-infective, and anti-inflammatory activities, and offer promise as potential adjuvants, cotreatments, or alternatives to cytotoxic chemotherapeutics, antibiotics, and nonsteroidal anti-inflammatory drugs. [15][16][17] Most nanozymes in preclinical development have single-enzyme-like activity, and are thus limited by insufficient catalytic efficiency, restricted availability of substrate types and concentrations, and activity under single identifiable catalytic conditions. In comparison, those with multienzyme-like activities carry advantages of high catalytic efficiency via amplification or cascade reactions, adaptive responses to dissimilar catalytic conditions, multifunctionality in diverse pathological processes, and capacities to overcome the impediment of insufficient substrates via "self-provision." [18] At present, most reported nanozymes with multienzyme-like activities are metal-based, owing to their unsaturated sites from the inherent structure of metal atoms and the valence changes of the metal centers in case of transition metals. [4] In the last decade, researchers have studied catalytic effects and regulation rules and design schemes of metal-based nanozymes with multienzyme-like activities (MNMs), with goals to remarkably improve their therapeutic efficiency and broaden their range of applications. [15,[19][20][21][22][23][24][25] Previous review articles have discussed the spatial structures and catalytic mechanisms of nanozymes from the perspective of their physical properties, or have summarized the effects of a few types of nanozymes with potential medical applications. [4,6,[26][27][28][29][30][31][32] However, clinical relevance stands as the core motivator of nanozyme research. Therefore, this review concentrates on MNMs. This work focuses on the biological effects of nanozymes based on their intracellular interactions, intending to analyze mechanisms of action and potential therapeutic applications. Herein, we summarize MNMs, their impacts on pathogenesis, underlying mechanisms, potential medical Most nanozymes in development for medical applications only exhibit singleenzyme-like activity, and are thus limited by insufficient catalytic activity and dysfunctionality in complex pathological microenvironments. To overcome the impediments of limited substrate availabilities and concentrations, some metal-based nanozymes may mimic two or more activities of natural enzymes to catalyze cascade reactions or to catalyze multiple substrates simultaneously, thereby amplifying catalysis. Metal-based nanozymes with multienzyme-like activities (MNMs) may adapt to dissimilar catalytic conditions to exert different enzyme-like effects. ...

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A hyaluronic acid/platelet-rich plasma hydrogel containing MnO2 nanozymes efficiently alleviates osteoarthritis in vivo

Cited by 61 publications

References 55 publications

Stimulus‐Responsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy

Stimulus‐Responsive Drug Delivery Nanoplatforms for Osteoarthritis Therapy

Designing functional hyaluronic acid-based hydrogels for cartilage tissue engineering

Metal‐Based Nanozymes with Multienzyme‐Like Activities as Therapeutic Candidates: Applications, Mechanisms, and Optimization Strategy

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