1999
DOI: 10.1128/mcb.19.11.7610
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A Human TATA Binding Protein-Related Protein with Altered DNA Binding Specificity Inhibits Transcription from Multiple Promoters and Activators

Abstract: The TATA binding protein (TBP) plays a central role in eukaryotic and archael transcription initiation. We describe the isolation of a novel 23-kDa human protein that displays 41% identity to TBP and is expressed in most human tissue. Recombinant TBP-related protein (TRP) displayed barely detectable binding to consensus TATA box sequences but bound with slightly higher affinities to nonconsensus TATA sequences. TRP did not substitute for TBP in transcription reactions in vitro. However, addition of TRP potentl… Show more

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Cited by 92 publications
(111 citation statements)
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“…59 TRF2 is the TRF protein with the least similarity to TBP. [60][61][62][63][64][65] In 1999-2000, when different research groups have cloned TRF2 from multiple species, different names were coined. The name TRF2 was used for Drosophila 64 and humans, 65 as it followed the discovery of TRF1 in Drosophila.…”
Section: Tbp-related Factorsmentioning
confidence: 99%
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“…59 TRF2 is the TRF protein with the least similarity to TBP. [60][61][62][63][64][65] In 1999-2000, when different research groups have cloned TRF2 from multiple species, different names were coined. The name TRF2 was used for Drosophila 64 and humans, 65 as it followed the discovery of TRF1 in Drosophila.…”
Section: Tbp-related Factorsmentioning
confidence: 99%
“…The name TRF2 was used for Drosophila 64 and humans, 65 as it followed the discovery of TRF1 in Drosophila. It was also named TLP (TATA-like protein; identified in mouse and humans), 62,63 TLF (TBP-like factor; identified in C. elegans), 60,66 TRP (TBP-related protein; identified in humans) 61 and TBPL1 (TBP-like 1; L is used by the Human Gene Nomenclature Committee to denote paralogs of named genes), based on its homology to TBP and perhaps, taking into account that there is no vertebrate TRF1. TRF2 is involved in RNAP II transcription.…”
Section: Tbp-related Factorsmentioning
confidence: 99%
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“…En effet, trois protéines TRF1 (TBP-related factor 1), TLF (TBP-like factor)/TRF2 et TRF3 ont été identifiées et caractérisées [11][12][13][14][15][16][17]. La similarité entre ces protéines est limitée au domaine carboxyterminal conservé (Figure 2A-C …”
Section: Des Protéines Apparentées à Tbpunclassified