A human epidermal growth factor-curcumin bandage bioconjugate loaded with mesenchymal stem cell for in vivo diabetic wound healing

Mohanty, Chandana; Pradhan, Jyotsnamayee

doi:10.1016/j.msec.2020.110751

Cited by 60 publications

(47 citation statements)

References 38 publications

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“…Mohantya and Pradhan formulated chitosan-alginate bandages co-encapsulated with curcumin and human epidermal growth factor (EGF)/mesenchymal stem cells (MSCs) for application in diabetic wound healing [ 110 ]. The atomic force microscopy (AFM) and SEM results demonstrated that the formulated sponges possessed sponge-like with microporous morphology beneficial for the transportation of oxygen and nutrients to support mesenchymal stem cell attachment and proliferation.…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

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Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

“…The in vitro drug release profile was an initial burst release of 52% in 2 days followed by a sustained drug release of 84% in 15 days. The wound closure of drug-loaded polymeric sponges on diabetic rat model was prominent with good re-epithelialization on 12th day when compared to the untreated wounds [ 110 ].…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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“…Mohanty & Sahoo, 2017). Oxidative stress and inflammation have an important role in wound healing process and curcumin may exert a wound healing activity due its antioxidant and anti-inflammatory properties (C. Mohanty & Pradhan, 2020;C. Mohanty & Sahoo, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Topical curcumin administration has been demonstrated more noticeable effects on wound healing than oral administration (Merrell et al, 2009;C. Mohanty, Das, et al, 2012;C. Mohanty & Pradhan, 2020).…”

Section: Introductionmentioning

confidence: 99%

Curcumin nanoformulations for antimicrobial and wound healing purposes

Salehi

Rodrigues

Peron

et al. 2021

Phytotherapy Research

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The development and spread of resistance to antimicrobial drugs is hampering the management of microbial infectious and wound healing processes. Curcumin is the most active and effective constituent of Curcuma longa L., also known as turmeric, and has a very long and strong history of medicinal value for human health and skincare. Curcumin has been proposed as strong antimicrobial potentialities and many attempts have been made to determine its ability to conjointly control bacterial growth and promote wound healing. However, low aqueous solubility, poor tissue absorption and short plasma half‐life due its rapid metabolism needs to be solved for made curcumin formulations as suitable treatment for wound healing. New curcumin nanoformulations have been designed to solve the low bioavailability problem of curcumin. Thus, in the present review, the therapeutic applications of curcumin nanoformulations for antimicrobial and wound healing purposes is described.

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“…Within the complex healing process, other growth factors such as EGF (epidermal growth factor), VEGF (vascular endothelial growth factor), and FGF (fibroblast growth factor) intervene. Consequently, EGF overall promotes wound healing first by activating the epidermal growth factor receptor (EGFR) signaling path [ 18 ], which subsequently will lead to an enhanced cell migration (keratinocyte, endothelial cells, and fibroblast) at the injured area, and also will promote the angiogenesis and proliferation [ 19 ]. The main role played by VEGF is in the process of angio- and/or vasculo-genesis, essential in wound healing, but also it contributes significantly to the improvement of collagen deposition and re-epithelialization.…”

Section: Wound Healingmentioning

confidence: 99%

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

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Currently, despite the thoroughgoing scientific research carried out in the area of wound healing management, the treatment of skin injuries, regardless of etiology remains a big provocation for health care professionals. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, should also maintain a humid medium at the wound interfacing, and be easily removed without trauma. For the development of functional and bioactive dressings, they must meet different conditions such as: The ability to remove excess exudates, to allow gaseous interchange, to behave as a barrier to microbes and to external physical or chemical aggressions, and at the same time to have the capacity of promoting the process of healing by stimulating other intricate processes such as differentiation, cell adhesion, and proliferation. Over the past several years, various types of wound dressings including hydrogels, hydrocolloids, films, foams, sponges, and micro/nanofibers have been formulated, and among them, the electrospun nanofibrous mats received an increased interest from researchers due to the numerous advantages and their intrinsic properties. The drug-embedded nanofibers are the potential candidates for wound dressing application by virtue of: Superior surface area-to volume ratio, enormous porosity (can allow oxy-permeability) or reticular nano-porosity (can inhibit the microorganisms’adhesion), structural similitude to the skin extracellular matrix, and progressive electrospinning methodology, which promotes a prolonged drug release. The reason that we chose to review the formulation of electrospun nanofibers based on polysaccharides as dressings useful in wound healing was based on the ever-growing research in this field, research that highlighted many advantages of the nanofibrillary network, but also a marked versatility in terms of numerous active substances that can be incorporated for rapid and infection-free tissue regeneration. In this review, we have extensively discussed the recent advancements performed on electrospun nanofibers (eNFs) formulation methodology as wound dressings, and we focused as well on the entrapment of different active biomolecules that have been incorporated on polysaccharides-based nanofibers, highlighting those bioagents capable of improving the healing process. In addition, in vivo tests performed to support their increased efficacy were also listed, and the advantages of the polysaccharide nanofiber-based wound dressings compared to the traditional ones were emphasized.

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A human epidermal growth factor-curcumin bandage bioconjugate loaded with mesenchymal stem cell for in vivo diabetic wound healing

Cited by 60 publications

References 38 publications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Curcumin nanoformulations for antimicrobial and wound healing purposes

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

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