Higher Education as a transforming instrument in societies raises the need for universities and Higher Education Institutions (HEIs) as a whole to be leaders in the current paradigm of the time. The objectives of this study are to verify and analyze the movement and actions around the world that drove and started the conceptual model of Sustainable University (SU), as well as these ideas that started in Brazil and their implications for the reality of the Brazilian Amazon Region. A timeline has been sketched and provides additional theoretical insights into universities’ involvement in events before and after the sustainable development process. The methodological procedures were based on a wide literature review in scientific databases that gather journals with satisfactory impact factors; with the refinement of the searches, 87 scientific articles supported the analysis of this study. The results show that universities have played a prominent role on the world stage since 1950, in the post-war period. In the 1970s, HEIs sought to engage in the design of the new paradigm, and in the 1980s it is enunciated as Sustainable Development and conceptualized by the Sustainability approach. Universities, which had been active in discussions and events related to sustainability from the late 1980s onwards, began to organize themselves more effectively and promote sustainable initiatives to become examples of sustainability. Currently, many HEIs from countries in Europe and North America stand out in the initiatives. In Brazil, according to a global classifier, some HEIs seek to align themselves towards the SU model. Until 2019, no university in the Brazilian Amazon region had integrated the ranking, but in 2020, two appear in the list. It appears that information on the sustainability of universities inserted in the context of the Brazilian Amazon is still incipient.