A Human Clinical, Histological, Histomorphometrical, and Radiographical Study on Biphasic<scp>HA</scp>‐Beta‐<scp>TCP</scp>30/70 in Maxillary Sinus Augmentation

Mangano, Carlo; Sinjari, Bruna; Shibli, Jamil Awad; Mangano, Francesco; Hamisch, Sabine; Piattelli, Adriano; Perrotti, Vittoria; Iezzi, Giovanna

doi:10.1111/cid.12145

Cited by 53 publications

(68 citation statements)

References 43 publications

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“…Among these regenerative techniques, maxillary sinus augmentation [3][4][5][6][7], guided bone regeneration (GBR) [8], and split-crest techniques [9] are the most commonly used procedures to restore the ideal anatomical bone conditions and to allow simultaneous and/or subsequent placement of dental implants.…”

Section: Introductionmentioning

confidence: 99%

Implant stability in the posterior maxilla: a controlled clinical trial

Gomes¹

2017

http://isrctn.com/

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Aim. To evaluate the primary and secondary stability of implants in the posterior maxilla. Methods. Patients were allocated into three groups: (A) native bone, (B) partially regenerated bone, and (C) nearly totally regenerated bone. Insertion torque (IT) and implant stability quotient (ISQ) were measured at placement, to evaluate whether satisfactory high primary stability (IT ≥ 45 N/cm; ISQ ≥ 60) was achieved; ISQ was measured 15, 30, 45, and 60 days after placement, to investigate the evolution to secondary stability. Results. 133 implants (Anyridge5, Megagen) were installed in 59 patients: 55 fixtures were placed in Group A, 57 in Group B, and 21 in Group C. Fifty-two implants had satisfactory high primary stability (IT ≥ 45 N/cm; ISQ ≥ 60). A positive correlation was found between all variables (IT, ISQ at t = 0, t = 60), and statistically higher IT and ISQ values were found for implants with satisfactory high primary stability. Significant differences were found for IT and ISQ between the groups (A, B, and C); however, no drops were reported in the median ISQ values during the healing period. Conclusions. The evaluation of the primary and secondary implant stability may contribute to higher implant survival/success rates in critical areas, such as the regenerated posterior maxilla. The present study is registered in the ISRCTN registry with ID ISRCTN33469250.

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Section: Introductionmentioning

confidence: 99%

Implant stability in the posterior maxilla: a controlled clinical trial

Gomes¹

2017

http://isrctn.com/

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“…One of the most important criteria for an ideal bone tissue engineering scaffold is that the scaffold consists of a highly interconnected porous network with pore sizes large enough for cell migration, fluid exchange, and eventually tissue ingrowth and vascularization [12]. Although synthetic calcium phosphate ceramics with their excellent biocompatibility are designed to mimic the native extracellular matrix as closely as possible [13], the porous network of the artificial bone scaffold still cannot compare to natural bone in terms of structure and function.…”

Section: Introductionmentioning

confidence: 99%

The Possible Roles of Biological Bone Constructed with Peripheral Blood Derived EPCs and BMSCs in Osteogenesis and Angiogenesis

Zhao

et al. 2016

BioMed Research International

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This study aimed to determine the possible potential of partially deproteinized biologic bone (PDPBB) seeded with bone marrow stromal cells (BMSCs) and endothelial progenitor cells (EPCs) in osteogenesis and angiogenesis. BMSCs and EPCs were isolated, identified, and cocultured in vitro, followed by seeding on the PDPBB. Expression of osteogenesis and vascularization markers was quantified by immunofluorescence (IF) staining, immunohistochemistry (IHC), and quantitive real-time polymerase chain reaction (qRT-PCR). Scanning electron microscope (SEM) was also employed to further evaluate the morphologic alterations of cocultured cells in the biologic bone. Results demonstrated that the coculture system combined with BMSCs and EPCs had significant advantages of (i) upregulating the mRNA expression of VEGF, Osteonectin, Osteopontin, and Collagen Type I and (ii) increasing ALP and OC staining compared to the BMSCs or EPCs only group. Moreover, IHC staining for CD105, CD34, and ZO-1 increased significantly in the implanted PDPBB seeded with coculture system, compared to that of BMSCs or EPCs only, respectively. Summarily, the present data provided evidence that PDPBB seeded with cocultured system possessed favorable cytocompatibility, provided suitable circumstances for different cell growth, and had the potential to provide reconstruction for cases with bone defection by promoting osteogenesis and angiogenesis.

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“…These techniques include onlay/inlay bone grafting [6, 7], distraction osteogenesis [8], maxillary sinus augmentation [9], inferior alveolar nerve transposition [10], alveolar ridge split [11], and guided bone regeneration (GBR) with resorbable [12] and nonresorbable membranes, such as those in polytetrafluoroethylene (PTFE) [13] or titanium [14]. …”

Section: Introductionmentioning

confidence: 99%

Alveolar Ridge Reconstruction with Titanium Meshes and Simultaneous Implant Placement: A Retrospective, Multicenter Clinical Study

Gomes¹,

Freixas²,

Han³

et al. 2016

BioMed Research International

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Objective. To evaluate horizontal bone gain and implant survival and complication rates in patients treated with titanium meshes placed simultaneously with dental implants and fixed over them. Methods. Twenty-five patients treated with 40 implants and simultaneous guided bone regeneration with titanium meshes (i–Gen®, MegaGen, Gyeongbuk, Republic of Korea) were selected for inclusion in the present retrospective multicenter study. Primary outcomes were horizontal bone gain and implant survival; secondary outcomes were biological and prosthetic complications. Results. After the removal of titanium meshes, the CBCT evaluation revealed a mean horizontal bone gain of 3.67 mm (±0.89). The most frequent complications were mild postoperative edema (12/25 patients: 48%) and discomfort after surgery (10/25 patients: 40%); these complications were resolved within one week. Titanium mesh exposure occurred in 6 patients (6/25 : 24%): one of these suffered partial loss of the graft and another experienced complete graft loss and implant failure. An implant survival rate of 97.5% (implant-based) and a peri-implant marginal bone loss of 0.43 mm (±0.15) were recorded after 1 year. Conclusions. The horizontal ridge reconstruction with titanium meshes placed simultaneously with dental implants achieved predictable satisfactory results. Prospective randomized controlled trials on a larger sample of patients are required to validate these positive outcomes.

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A Human Clinical, Histological, Histomorphometrical, and Radiographical Study on BiphasicHA‐Beta‐TCP30/70 in Maxillary Sinus Augmentation

Abstract: The present results indicate histologically the high biocompatibility and osteoconductivity of HA-beta-TCP 30/70, and clinically its successful use for sinus augmentation procedures.

Cited by 53 publications

References 43 publications

Implant stability in the posterior maxilla: a controlled clinical trial

Implant stability in the posterior maxilla: a controlled clinical trial

The Possible Roles of Biological Bone Constructed with Peripheral Blood Derived EPCs and BMSCs in Osteogenesis and Angiogenesis

Alveolar Ridge Reconstruction with Titanium Meshes and Simultaneous Implant Placement: A Retrospective, Multicenter Clinical Study

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