A Hospital-based Survey on the Prevalence of Bronchial Asthma in Patients with Allergic Rhinitis in Southern China

Hong, Haiyu; Yang, Qintai; Zuo, Kejun; Chen, Xinye; Xia, Wenfei; Lv, Minhui; Li, Xiaomin; Xu, Geng; Li, Hua-Bin; Fan, Yunping

doi:10.2500/ajra.2013.27.3951

Cited by 15 publications

(31 citation statements)

References 18 publications

(28 reference statements)

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“…In 2009, Li et al 28 surveyed 6,304 patients suffering from asthma and/or rhinitis in 17 cities from four regions of China and showed that Dermatophagoides farinae and Dermatophagoides pteronyssinus were the predominant aeroallergens in perennial/persistent AR individuals in China. Similar results were gained by the study in single regions such as Guangzhou,25 Xiamen, 25 Quanzhou,29 Zhengzhou,30 Qingdao,31 Yichang32 and Shanghai 33. The overall prevalence of specific immunoglobulin E (sIgE)-mediated sensitization to aeroallergens in 5,486 patients with AR who visited the ear, nose, and throat outpatient clinic in Guangzhou, the largest city in Southern China from January 2005 to December 2014 were as follows: 84.4% for house dust mites (HDMs), 23.4% for pet allergens, 21.1% for cockroaches, 9.1% for mold allergens, 7.7% for tree pollen and 6.0% for weed pollen 34.…”

Section: Profiles Of Sensitization To Inhaled Allergenssupporting

confidence: 84%

“…It has been reported that the incidence of AR accompanied by rhinosinusitis, asthma or atopic dermatitis was significantly higher among individuals having self-reported AR compared to the general population,9 while the occurrence of comorbidities such as allergic conjunctivitis, cough and asthma gradually increased from intermittent mild, persistent mild and intermittent moderate-severe to persistent moderate-severe in terms of an AR children study in Shanghai 23. To be exact, a cross-sectional, hospital-based survey of 1,931 AR patients in two modernized cities (Guangzhou and Zhuhai) in Southern China and the prevalence of concomitant asthma for AR patients is 5.33% (103 of 1,931) 25. Comparatively, another cross-sectional questionnaire study surveyed the diagnostic methods and treatment patterns for asthma-AR comorbidity by primary respiratory medicine specialty (PRMs) from 98 hospitals across China and the PRMs reported an estimated prevalence of asthma-AR comorbidity of > 30% at their clinics 26.…”

Section: Current Status Of Comorbid Allergic Diseasesmentioning

confidence: 99%

“…In addition, obesity proved to increase the prevalence of AR51 and excessive weight gain was also confirmed to be an important risk factor developing AR during adolescence, especially among infants born small for their gestational age 22. Self-medication with antibiotics (OR, 6.35),25 especially use of at least 1 course of antibiotics in the first year of life (OR, 7.61) was involved 17…”

Section: Risk Factors Associated With Ar Incidencementioning

confidence: 99%

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Increasing Prevalence of Allergic Rhinitis in China

Zhang

2019

Allergy Asthma Immunol Res

165

111

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Allergic rhinitis (AR) is a critical public health, medical and economic problem in China. AR is also an important risk factor which will cause many diseases or disorders, especially in children. The trend of AR incidence is still on the rise in recent years and has had a significant effect on the general public. This significant increase is alarming, which highlights an urgent need for better understanding of the prevalence status and characteristics, sensitization patterns, and the associated risk factors of AR in order to improve treatment and develop effective prevention strategies.

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Section: Profiles Of Sensitization To Inhaled Allergenssupporting

confidence: 84%

Section: Current Status Of Comorbid Allergic Diseasesmentioning

confidence: 99%

Section: Risk Factors Associated With Ar Incidencementioning

confidence: 99%

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Increasing Prevalence of Allergic Rhinitis in China

Zhang

2019

Allergy Asthma Immunol Res

165

111

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“…Dust mites are the most common allergens in Southern China [ 24 ]. The allergen density in the air constantly varies in the subtropical climate.…”

Section: Discussionmentioning

confidence: 99%

Treatment of persistent allergic rhinitis via acupuncture at the sphenopalatine acupoint: a randomized controlled trial

Chen

Lin

et al. 2018

Trials

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BackgroundAllergic rhinitis is a common respiratory disease. Acupuncture is used to treat it in traditional Chinese medicine, and generally, the L120, ST2 and ST36 acupoints are selected in clinical practice. We report a new method of acupuncture at the sphenopalatine acupoint (SPA) for treatment of persistent allergic rhinitis (PAR). The effect of this treatment was investigated using two different needling depths. The efficacy of this treatment was associated with accurate stimulation of the sphenopalatine ganglion (SPG).Methods/DesignA total of 61 patients diagnosed with PAR were randomly allocated to either the acupuncture or the sham acupuncture group. The difference between the groups was the needle depth when acupuncture was administered, which was 50 mm and 20 mm. Alteration in total nasal symptom score (TNSS) was the primary outcome. Quality of life, medication dosages and adverse events were secondary outcomes, measured using the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ). Confidence assessment was performed to evaluate data from the treatment and follow-up periods.ResultsResults were: (1) average TNSS in the treatment group was significantly lower than in the control group at week 4 (median and 25th and 75th percentiles were 5.00 (4.00, 7.00) and 8.00 (7.00, 10.00), respectively (P < 0.001)). However, scores in the two groups were not significantly different at week 12; (2) quality of life (RQLQ) was significantly improved at week 2 in the treatment group compared to the control group (scores of 35.47 ± 8.20 and 45.48 ± 8.84; P < 0.001); (3) during the follow-up period, the medication dosage in the treatment group was much lower than in the control group (3.64 ± 1.45 and 6.14 ± 2.34; P < 0.05); and (4) no adverse events were observed in either group during treatment.ConclusionsThis pilot study revealed a profound effect of acupuncture at the SPA on prevention of PAR development. The TNSS in the treatment group (needle depth 50 mm), was significantly lower than in the control group (needle depth of only 20 mm). Our result demonstrates that performing acupuncture directly at the SPA to stimulate the SPG is an effective method to treat PAR.Trial registrationAcupuncture Clinical Trial Registry, AMCTR-OOR-16000014 and Chinese Clinical Trial Register, ChiCTR-IOR-16009211. Registered on 1 September 1 2016.

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“…Forward steps with basic science, pathophysiology, 25 clinical trials, clinical guidelines, and evidence-based medicine 1,2,4,5,10,11,13,[14][15][16][17]20,21 and one step back with analysis of real-life outcomes (including analysis of failures) 3,6,7,9,12,13,18,19,23,24 will keep us progressing in the right direction, toward better patient care. Forward steps with basic science, pathophysiology, 25 clinical trials, clinical guidelines, and evidence-based medicine 1,2,4,5,10,11,13,[14][15][16][17]20,21 and one step back with analysis of real-life outcomes (including analysis of failures) 3,6,7,9,12,13,18,19,23,24 will keep us progressing in the right direction, toward better patient care.…”

Section: Progressmentioning

confidence: 99%

Editorial

Corey¹

2013

Am J Rhinol�Allergy

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T he current issue of the American Journal of Rhinology and Allergy highlights two major themes that frequently confront the allergist/rhinologist: chronic rhinosinusitis with nasal polyps (CRSwNPs) and allergic rhinitis (AR). Also addressed in this issue is the rare clinical occurrence of hereditary angioedema (HAE), which deserves attention because of newly developed therapies to prevent potentially life-threatening consequences. In a series of excellent articles, the basic challenges confronting the allergist/rhinologist regarding definition, diagnosis, and treatments of these disorders are rigorously evaluated. ALLERGIC RHINITISThe ideal definition of AR would help clinicians and researchers to distinguish it from nonallergic rhinitis (NAR) and mixed rhinitis (AR ϩ NAR). Bernstein 1 points out this may be difficult because of overlapping symptoms. A careful history followed by skin (or in vitro) testing to assess allergic status is recommended. Although Bernstein suggests that therapeutic response may aid diagnosis, more research is needed to determine if this assumption is correct. Providing insight into therapeutic response is the article by Gawlik et al. 2 , in which the mechanism of action of intranasal azelastine therapy is evaluated in NAR. These authors report that an untreated NAR control group showed greater substance P release in nasal lavage fluids after challenge with hypertonic saline than did an azelastine pretreated group. A different approach to defining AR is taken by Larenas-Linnemann et al. 3 who studied patients diagnosed with AR by Mexican allergists. They categorized patients according to U.S. coding practices as seasonal AR and perennial AR and compared it with the European Allergic Rhinitis and Its Impact on Asthma classifications of intermittent versus persistent and mild versus moderate-severe. They observed that the physicians tended to "overdiagnose" perennial AR and intermittent-persistent compared with the patient's assessment.Comorbidities, risk factors, and physiological triggers of AR are explored by several authors. Haavisto et al., 4 using acoustic rhinometry, measured nasal patency changes induced by physical exercise in AR and asthma and found lower area before and after exercise in the allergic group. All three groups (allergic, asthmatic, and controls) experienced improved (ϳ15%) nasal volume/area after exercise. Increased body mass index in AR patients was found by Ciprandi et al. 5 to be associated with increased markers of inflammation compared with normal weight controls and may increase risk for early bronchial impairment. In Western countries, the incidence of concomitant AR and asthma is common, with some estimates as high as 50%. 1 Hong et al. 6 studied the comorbidity of AR and asthma in two southern Chinese cities via a hospital-based cross-sectional survey. The prevalence of concomitant bronchial asthma was only 5.33%.

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A Hospital-based Survey on the Prevalence of Bronchial Asthma in Patients with Allergic Rhinitis in Southern China

Abstract: Our findings suggested the risk factors of concomitant BA in AR patients may be helpful to establish preventive strategies.

Cited by 15 publications

References 18 publications

Increasing Prevalence of Allergic Rhinitis in China

Increasing Prevalence of Allergic Rhinitis in China

Treatment of persistent allergic rhinitis via acupuncture at the sphenopalatine acupoint: a randomized controlled trial

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