A hospital-based study of hepatic dysfunction in children with dengue fever

Singh, Shipra; Meena, Jitendra Kumar; Verma, Chaman Ram; Bhaskar, Vipul

doi:10.1016/s2222-1808(15)60965-3

Cited by 4 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elevation of AST was more compared to ALT in the present study and similar observations was made by others also [4,8,13,16]. AST rise more than ALT in dengue, probably due to multi-organ affection in dengue, hence other sources of AST contributes to its rise (erythrocytes, cardiac, skeletal, renal, brain).…”

Section: Original Research Articlesupporting

confidence: 91%

“…Ascites was seen in 8(15.38%) patients in our study. In a study by Selvanet al 35.6% had ascites while Singh et alreported ascites in 23% cases [4,16]. In our study none of the patients had hepatic encephalopathy or acute liver failure.…”

Section: Original Research Articlesupporting

confidence: 42%

“…Only one patient of dengue with warning signs had TSB of 2.4mg/dl. Singh et al observed mean TSB in severe dengue to be significantly more compared to DF with warning signs and without warning signs [16].…”

Section: Original Research Articlementioning

confidence: 99%

See 2 more Smart Citations

Prevalence of hepatic dysfunction in children with dengue fever

2019

View full text Add to dashboard Cite

Background: Dengue is one disease entity with different clinical presentations and often with unpredictable clinical evolution and outcome. The degree of liver dysfunction in children with dengue infection varies from mild injury with elevation of transaminases to severe injury with jaundice and liver cell failure. This study was undertaken to find the prevalence of hepatic dysfunction in children admitted with Dengue fever. Methods: All children with serologically (dengue NS1 antigen detection and/or dengue IgM Mac ELISA) confirmed dengue fever aged between 2 months and 12 years were included in the study. Children with other etiologies of hepatitis were excluded. Liver function tests including bilirubin, transaminases and prothrombin time (PT) were done. Prevalence and severity of hepatic dysfunction were statistically analysed and compared between different categories of dengue fever severity. Results: Hepatic dysfunction was present in 35 (67.30%) of the 52 children included in the study.About 85.71% of the children with dengue fever in the age group of 2 months to 1 year had hepatic dysfunction. In children with severe dengue, 83.3% had hepatic dysfunction.Raised liver enzymes in 32(61.53%), hepatomegaly in 21(40.48%), INR≥1.5 in 8 (15.38%) and jaundice in 1(1.92%) children were the manifestations. None of the patients had acute hepatic failure or hepatic encephalopathy.Association of hepatomegaly with increasing disease severity was statistically significant (p = 0.0262). Hepatic dysfunction was present in 83.33% and 87.5% of children with abdominal pain and clinical fluid accumulation respectively. Of the 32 patients (61.53%) with elevated transaminases, 18 (51.42%) had elevated levels of AST alone, 40% had elevation of AST and ALT both. Conclusions: The prevalence of hepatic dysfunction among children with dengue fever is 67.30%, more commonly observed in severe forms of dengue. Spectrum of hepatic involvement ranges from raised liver enzymes without jaundice to clinically evident jaundice. Hepatic dysfunction is commonly observed in children with abdominal pain and clinical fluid accumulation.

show abstract

Section: Original Research Articlesupporting

confidence: 91%

Section: Original Research Articlesupporting

confidence: 42%

See 1 more Smart Citation

Prevalence of hepatic dysfunction in children with dengue fever

2019

View full text Add to dashboard Cite

show abstract

“…Dengue viral infections are known for presenting a diverse clinical spectrum, ranging from asymptomatic illness to fatal dengue shock syndrome (DSS). 16 In our study, we have found that the mean age of the patients was 6.5±3.5 years with age range of 6 months to 15 years in Alam AS et al study. 6 Malavige GN et al found mean age of the patients 7.9±2.9 years and their age range was from 1 month to 12 years8 while Ahmed et al, found mean age 9.0±2.8 years with an age range of 2.5-12 years.…”

Section: Discussionmentioning

confidence: 45%

A comparative study of in clinico-pathological profile in dengue shock syndrome versus other types children's at tertiary health care center

Shah

Phirke

2017

Int J Res Med Sci

View full text Add to dashboard Cite

Background: Dengue a mosquito borne arboviral disease is caused by one of the serotypes of dengue virus (DEN-1, DEN-2, Den-3, DEN-4) belonging to the family Flaviviridae. The objective of this study was to study clinco-pathological profile of Dengue shock syndrome versus Other types children's at tertiary health care center.Methods: This was Cross sectional observational study was conducted in a tertiary care hospital in the Department of Pediatrics after obtaining approval from the institutional Ethical Committee. The study was carried out over a period of one & half years from January 2015 to June 2016 Statistical analysis done by Chi-square, ANOVA, Paired t test SPSS version 22 (IBM SPSS Statistics, Somers NY, USA) was used to analyze data.Results: Mean age of patients were 8.08±2.72 years, majority of cases were females (51.9%) and 48.1% were males, the clinical features like hepatomegaly, Ascites Pleural Effusion significantly present in DSS (P<0.001). In the study, there was no significant difference in symptoms and severity of dengue fever except for convulsion Thrombocytopenia (platelet<1lakh/cmm) was observed in 74% of cases, leucopenia (total leukocyte count <4000/cmm) was observed in 56% of cases, haemocrit more than 40 was observed in 21.27% cases. Dengue shock syndrome had acute kidney injury, CCF and encephalopathy. This observation of complications between dengue severity was statistically significant. There was significant difference in haematocrit values between three diagnoses of dengue fever from day 1 till day 4. Initially higher haematocrit was observed in Dengue shock syndrome, later goes on decreasing.Conclusions: It can be concluded from our study that significantly dengue shock syndrome had acute kidney injury, CCF and encephalopathy. There was significant difference in hematocrit values between three diagnoses of dengue fever from day 1 till day 4. Initially higher hematocrit was observed in dengue shock syndrome.

show abstract

“…Dengue infection is one of the important causes for acute hepatic failure in children aged 1 -15 years contributing to 34.3% of the cases. 9,10 There is good correlation between Serum aminotransferase levels and occurrence of hepatic dysfunction and spontaneous bleeding and can be used to predict the same. 11 In this study, hepatic dysfunction was found in both the non-shock group (4.2%) and the shock group (17.9%) as defined by those who had SGPT more than 5 times upper normal values (SGPT > 200 U/L).…”

Section: Resultsmentioning

confidence: 99%

Pattern of changes in liver enzymes SGPT, SGOT level during Dengue infection in hospitalized pediatrics patients in tertiary care centre

Jeergal¹,

Ahmed²,

Siddiqa³

et al. 2019

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Hepatic involvement is not an uncommon in dengue viral infection, which presents with elevation in serum aminotransferases due to reactive hepatitis. The study is aimed to know the pattern of changes in hepatic enzyme levels in dengue infection in pediatric patients and to assess it with clinical presentation of dengue in particularly patients without and with shock.Methods: Pediatric patients with serologically confirmed Dengue viral infection were enrolled in the study and divided clinically into a shock group and a non-shock group. SGPT and SGOT levels were measured from day one of fever onset till 7 days and within 3 days after shock in the shock group. Student t-test was used to analyze the statistical data.Results: 100 patients with a mean age of 8±2.6 years were included in the study. The incidence of abnormal SGOT and SGPT levels were 96.9% and 51.1% in the shock group, and 92.2% and 45% in the non-shock group respectively. 30% and 17.9% of the patients in shock group and only 9.9% and 4.2% in non-shock group had the respective SGOT and SGPT levels > 200 U/L. Patients in shock group had statistically higher levels of Serum aminotransferase compared to the non-shock group. SGOT tended to increase starting from one day before shock and continued to increase within a few days whereas SGPT was less likely to be affected.Conclusions: Pediatric patients with Dengue infection have raised Aminotransferases in particular SGOT, which is higher than SGPT level. Aminotransferase levels in shock patients are significantly high and increases up to 3 days.

show abstract

A hospital-based study of hepatic dysfunction in children with dengue fever

Cited by 4 publications

References 14 publications

Prevalence of hepatic dysfunction in children with dengue fever

Prevalence of hepatic dysfunction in children with dengue fever

A comparative study of in clinico-pathological profile in dengue shock syndrome versus other types children's at tertiary health care center

Pattern of changes in liver enzymes SGPT, SGOT level during Dengue infection in hospitalized pediatrics patients in tertiary care centre

Contact Info

Product

Resources

About