A history of pernicious anaemia

Chanarin, I.

doi:10.1111/j.1365-2141.2000.02238.x

Cited by 11 publications

(12 citation statements)

References 48 publications

(38 reference statements)

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“…The landmark studies of Minot and Murphy on the cure of PA by a meat and liver diet were based on a fortuitous misinterpretation of Whipple's report on the efficiency of such diet promoting hemoglobin regeneration in dogs made anemic by venesection, 25 most likely representing iron deficiency and not Cbl depletion. Likewise, the seminal observations of Faber and Bloch 26 on gastric atrophy involving the proximal two thirds of the stomach are recognized not only as a major insight into the pathogenesis of PA, but also as a characteristic feature of achylia gastrica, a syndrome of chronic IDA associated with gastric atrophy first described by the same author in 1909 27 and recognized subsequently as a major cause of IDA.…”

Section: Discussionmentioning

confidence: 99%

Variable hematologic presentation of autoimmune gastritis: age-related progression from iron deficiency to cobalamin depletion

Hershko

Ronson

Souroujon

et al. 2006

Blood

195

141

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Section: Discussionmentioning

confidence: 99%

Variable hematologic presentation of autoimmune gastritis: age-related progression from iron deficiency to cobalamin depletion

Hershko

Ronson

Souroujon

et al. 2006

Blood

195

141

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“…[23][24][25][26] PA is commonly associated with various autoimmune disorders, such as Hashimoto thyroiditis, insulin dependent diabetes mellitus, pure red cell aplasia and polyendocrinopathy. 4,[27][28][29] Recent studies highlighted that HLA-DRB1*03 and HLA-DRB1*04 alleles linked to autoimmune gastritis. 30…”

Section: Pathophysiology Of Pamentioning

confidence: 99%

Pernicious anemia: Pathophysiology and diagnostic difficulties

Htut

Thein

2021

J Evidence Based Medicine

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Pernicious anemia (PA) is the most common cause of vitamin B12 (cobalamin) deficiency anemia in the world. It is an autoimmune disease, comprising of salient features of autoimmune chronic atrophic gastritis (CAG) and cobalamin deficiency (CD).Although the anemia was first described as pernicious, it may well be controlled with vitamin B12 replacement. The onset and progression of PA is often insidious. Alternatively, patients may have no anemic symptoms since they become acclimatized to the subtle nature of the disease. Oftentimes, there is a possibility that the underlying disease may be missed unless a full blood count (FBC) is investigated, leading to hindrance in the treatment journey. Diagnostic challenges remain tangible for many practicing clinicians, since there is lack of reliable cobalamin assays to diagnose CD as well as clinical mimics, which simulate many other hematological conditions, such as myelodysplastic syndrome, acute leukemia, sideroblastic anemias, bone marrow failure states, thrombotic microangiopathy, and thromboembolism. Moreover, prompt recognition of the symptoms of CD is also vital, because some neurologic sequalae may become irreversible despite replenishing cobalamin. Herein, we discuss a literature review on the pathophysiology, challenging clinical presentations and diagnostic difficulties of PA.Since the cobalamin replacement therapy for PA is straightforward, it will not be discussed in this review.

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“…By 1910, 15 people had been transfused. All had severe chronic anaemia; some were diagnosed with pernicious anaemia, although it should be noted that many patients given this diagnosis at that time may not have truly had that disease (Chanarin, 2000). Five patients improved rapidly.…”

Section: Blood Transfusionmentioning

confidence: 99%

A hundred years of cascading – started by Paul Morawitz (1879–1936), a pioneer of haemostasis and of transfusion

Boulton¹

2006

Transfusion Medicine

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Morawitz is mainly remembered for clarifying the role of prothrombin in clotting, but his mature years saw him guide advances in transfusion therapy. He was among the first to describe haemolytic transfusion reactions and to advocate using blood anticoagulated by citrate. He was a talented organiser - founding the Leipzig Donor Centre during increasingly difficult economic and political times. An excellent general physician, his interest in clotting led to clinical work in thrombosis and angina, and the use of quinidine for cardiac dysfunction. Ironically he died of acute myocardial infarction two years after his first attack of angina and coronary thrombosis.

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A history of pernicious anaemia

Cited by 11 publications

References 48 publications

Variable hematologic presentation of autoimmune gastritis: age-related progression from iron deficiency to cobalamin depletion

Variable hematologic presentation of autoimmune gastritis: age-related progression from iron deficiency to cobalamin depletion

Pernicious anemia: Pathophysiology and diagnostic difficulties

A hundred years of cascading – started by Paul Morawitz (1879–1936), a pioneer of haemostasis and of transfusion

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