A History of Childhood Behavioral Inhibition and Enhanced Response Monitoring in Adolescence Are Linked to Clinical Anxiety

McDermott, Jennifer Martin; Pérez‐Edgar, Koraly; Henderson, Heather A.; Chronis‐Tuscano, Andrea; Pine, Daniel S.; Fox, Nathan A.

doi:10.1016/j.biopsych.2008.10.043

Cited by 206 publications

(237 citation statements)

References 17 publications

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“…Thus, the ERN captures the extent to which one notices, and reacts to, discrepancies between their intended and actual behaviors during goal-directed activities. Several research groups have reported that children and adults with elevated state anxiety or anxiety diagnoses show exaggerated ERN responses (eg, Gehring et al, 2000;Hajcak et al, 2003;Ladouceur et al, 2006;McDermott et al, 2009;Pailing and Segalowitz, 2004). The ERN is attributed to activity in the mPFC and is thought to reflect heightened attention to errors in performance (Yeung et al, 2004).…”

Section: Neural Correlates Of Controlmentioning

confidence: 99%

“…McDermott et al (2009) reported that adolescents with a childhood history of BI (14 months to 7 years) showed enhanced ERN responses on a modified Flanker task relative to adolescents without a history of BI. Further, the relation between earlier BI and the probability of a lifetime diagnosis of any clinically significant anxiety diagnosis as assessed by semistructured interviews with adolescents and their parents was moderated by the ERN amplitude.…”

Section: Neural Correlates Of Controlmentioning

confidence: 99%

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Behavioral Inhibition and Developmental Risk: A Dual-Processing Perspective

Henderson

Pine

Fox

2014

Neuropsychopharmacol

174

184

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Behavioral inhibition (BI) is an early-appearing temperament characterized by strong reactions to novelty. BI shows a good deal of stability over childhood and significantly increases the risk for later diagnosis of social anxiety disorder (SAD). Despite these general patterns, many children with high BI do not go on to develop clinical, or even subclinical, anxiety problems. Therefore, understanding the cognitive and neural bases of individual differences in developmental risk and resilience is of great importance. The present review is focused on the relation of BI to two types of information processing: automatic (novelty detection, attention biases to threat, and incentive processing) and controlled (attention shifting and inhibitory control). We propose three hypothetical models (Top-Down Model of Control; Risk Potentiation Model of Control; and Overgeneralized Control Model) linking these processes to variability in developmental outcomes for BI children. We argue that early BI is associated with an early bias to quickly and preferentially process information associated with motivationally salient cues. When this bias is strong and stable across development, the risk for SAD is increased. Later in development, children with a history of BI tend to display normative levels of performance on controlled attention tasks, but they demonstrate exaggerated neural responses in order to do so, which may further potentiate risk for anxiety-related problems. We conclude by discussing the reviewed studies with reference to the hypothetical models and make suggestions regarding future research and implications for treatment.

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Section: Neural Correlates Of Controlmentioning

confidence: 99%

Section: Neural Correlates Of Controlmentioning

confidence: 99%

Behavioral Inhibition and Developmental Risk: A Dual-Processing Perspective

Henderson

Pine

Fox

2014

Neuropsychopharmacol

174

184

View full text Add to dashboard Cite

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“…Analogous to the developmental progression of the BD liability, behavioral inhibition, specifically when it is characterized by poor autonomic regulation (Marshall & Stevenson-Hinde, 1998), typically appears during early childhood in individuals who will later develop anxiety (Hirshfeld-Becker et al, 2007;McDermott, et al, 2009), and anxiety may be an earlier expression of the common NE liability than depression. Anxiety is more likely than depression to onset during childhood, depression in child and adolescent samples is most often comorbid with anxiety (Anderson, Williams, McGee, & Silva, 1987;Angold, Costello, & Erkanli, 1999;Fleming, Offord, & Boyle, 1989), and the onset of anxiety tends to precede the onset of depression (Hettema, Kuhn et al, 2006;Kessler et al, 2005;Woodward & Fergusson, 2001).…”

Section: Liability For Internalizing Disordersmentioning

confidence: 99%

An Integrative Common Liabilities Model for the Comorbidity of Substance Use Disorders with Externalizing and Internalizing Disorders

Tully

Iacono

2014

Oxford Handbooks Online

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This paper presents an integrative research-derived model to explain comorbidity among SUDs, externalizing disorders, and internalizing disorders. This hierarchical model is based on phenotypic covariance among the disorders and latent common genetic liability. At the highest level of the hierarchy, general genetically-influenced biological dispositions to negative emotionality and behavioral disinhibition each give rise to spectra of related personality traits, cognitive processes, behavioral tendencies, and psychopathology that account for the pattern of co-occurrence among mental disorders. At the lowest level of the hierarchy, disorder-specific genetic and environmental effects explain the presence of some and not other disorders associated with a given general liability. Interplay between the general liabilities and both other genes and environmental factors throughout development affect the likelihood of developing specific mental disorders.

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“…Thus, reward-related tasks allow for probing a deficient allocation of attentional resources toward rewarding stimuli. Additionally, many individuals with anxiety disorders are hypersensitive to performance concerns and exhibit enhanced response monitoring McDermott et al 2009). Such heightened performance monitoring and concerns may be accentuated in reward tasks when rewards are contingent upon task performance Helfinstein et al 2011Helfinstein et al , 2012.…”

Section: Reward Processingmentioning

confidence: 99%

A Systems Neuroscience Approach to the Pathophysiology of Pediatric Mood and Anxiety Disorders

Tseng¹,

Leibenluft²,

Brotman³

2013

The Neurobiology of Childhood

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Emotional dysregulation is a core feature of pediatric mood and anxiety disorders. Emerging evidence suggests that these disorders are mediated by abnormalities in the functions and structures of the developing brain. This chapter reviews recent behavioral and functional magnetic resonance imaging (fMRI) research on pediatric mood and anxiety disorders, focusing on the neural mechanisms underlying these disorders. Throughout the chapter, we highlight the relationship between neural and behavioral findings, and potential novel treatments. The chapter concludes with directions for future research.

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A History of Childhood Behavioral Inhibition and Enhanced Response Monitoring in Adolescence Are Linked to Clinical Anxiety

Cited by 206 publications

References 17 publications

Behavioral Inhibition and Developmental Risk: A Dual-Processing Perspective

Behavioral Inhibition and Developmental Risk: A Dual-Processing Perspective

An Integrative Common Liabilities Model for the Comorbidity of Substance Use Disorders with Externalizing and Internalizing Disorders

A Systems Neuroscience Approach to the Pathophysiology of Pediatric Mood and Anxiety Disorders

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