A history and recent efforts of selected physiologically based pharmacokinetic modeling topics

Lin, Zhoumeng; Fisher, Jeffrey W.

doi:10.1016/b978-0-12-818596-4.00001-1

Cited by 4 publications

(4 citation statements)

References 89 publications

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“…Physiologically based pharmacokinetic (PBPK) modeling is a useful tool in the areas of drug development (Zhao et al., 2012), chemical risk assessment (Lin & Fisher, 2020; Tan et al., 2018), and drug tissue residue and withdrawal interval estimation in food animals for food safety assessment (Lautz et al., 2019; Lin et al., 2016). In the literature, there are about 40 published PBPK models in food animals, mainly in major species, but only three in sheep and goats (Craigmill, 2003; Lautz, Hoeks, et al., 2020; Leavens et al., 2012).…”

Section: Introductionmentioning

confidence: 99%

Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part III: Sheep and goat

Wang

Elwell-Cuddy

Baynes

et al. 2020

Vet Pharm & Therapeutics

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This report is the third in a series of studies that aimed to compile physiological parameters related to develop physiologically based pharmacokinetic (PBPK) models for drugs and environmental chemicals in food‐producing animals including swine and cattle (Part I), chickens and turkeys (Part II), and finally sheep and goats (the focus of this manuscript). Literature searches were conducted in multiple databases (PubMed, Google Scholar, ScienceDirect, and ProQuest), with data on relevant parameters including body weight, relative organ weight (% of body weight), cardiac output, relative organ blood flow (% of cardiac output), residual blood volume (% of organ weight), and hematocrit reviewed and statistically summarized. The mean and standard deviation of each parameter are presented in tables. Equations describing the growth curves of sheep and goats are presented in figures. When data are sufficient, parameter values are reported for different ages or production classes of sheep, including fetal sheep, lambs, and market‐age sheep (mature sheep). These data provide a reference database for developing standardized PBPK models to predict drug withdrawal intervals in sheep and goats, and also provide a basis for extrapolating PBPK models from major species such as cattle to minor species such as sheep and goats.

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Section: Introductionmentioning

confidence: 99%

Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part III: Sheep and goat

Wang

Elwell-Cuddy

Baynes

et al. 2020

Vet Pharm & Therapeutics

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“…Significant insights have been discovered using in silico methods to address challenges in tracing the pharmacokinetic profile of nanomedicines and potential toxicities. Therefore, PBPK modeling and simulation should be further explored. − Future applications of PBPK modeling in different fields, especially in toxicology and risk assessment, have been summarized previously …”

Section: Methods For Nanotoxicity Assessmentmentioning

confidence: 99%

“…246−248 Future applications of PBPK modeling in different fields, especially in toxicology and risk assessment, have been summarized previously. 249 In silico methods to investigate potential nanotoxicological adverse events are being implemented. However, some restrictions persist in their validation and use to move directly for clinical translation.…”

Section: Methods For Nanotoxicity Assessmentmentioning

confidence: 99%

Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology

et al. 2022

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Worldwide nanotechnology development and application have fueled many scientific advances, but technophilic expectations and technophobic demands must be counterbalanced in parallel. Some of the burning issues today are the following: (1) Where is nano today? (2) How good are the communication and investment networks between academia/research and governments? (3) Is there any spotlight application for nanotechnology? Nanomedicine is a particular arm of nanotechnology within the healthcare landscape, focused on diagnosis, treatment, and monitoring of emerging (such as coronavirus disease 2019, COVID-19) and contemporary (including diabetes, cardiovascular diseases, neurodegenerative disorders, and cancer) diseases. However, it may only represent the bright side of the coin. In fact, in the recent past, the concept of nanotoxicology has emerged to address the dark shadows of nanomedicine. The nanomedicine field requires more nanotoxicological studies to identify undesirable effects and guarantee safety. Here, we provide an overall perspective on nanomedicine and nanotoxicology as central pieces of the giant puzzle of nanotechnology. First, the impact of nanotechnology on education and research is highlighted, followed by market trends and scientific output tendencies. In the next section, the nanomedicine and nanotoxicology dilemma is addressed through the interplay of in silico, in vitro, and in vivo models with the support of omics and microfluidic approaches. Lastly, a reflection on the regulatory issues and clinical trials is provided. Finally, some conclusions and future perspectives are proposed for a clearer and safer translation of nanomedicines from the bench to the bedside.

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“…Physiologically-based pharmacokinetic (PBPK) models are tools utilized to simulate absorption, distribution, metabolism, and excretion over different exposure scenarios and to extrapolate exposures between animals and humans for single compounds or mixtures [ 27 ]. Traditional mixtures models have been and are still coded in parallel with lines of code for each individual chemical in the mixture, and repeated for each tissue simulated (e.g., Martin et al [ 28 ] and Ruiz et al [ 29 ]).…”

Section: Introductionmentioning

confidence: 99%

Complex Mixtures: Array PBPK Modeling of Jet Fuel Components

Sterner

Covington

Mattie

2023

Toxics

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An array physiologically-based pharmacokinetic (PBPK) model represents a streamlined method to simultaneously quantify dosimetry of multiple compounds. To predict internal dosimetry of jet fuel components simultaneously, an array PBPK model was coded to simulate inhalation exposures to one or more selected compounds: toluene, ethylbenzene, xylenes, n-nonane, n-decane, and naphthalene. The model structure accounts for metabolism of compounds in the lung and liver, as well as kinetics of each compound in multiple tissues, including the cochlea and brain regions associated with auditory signaling (brainstem and temporal lobe). The model can accommodate either diffusion-limited or flow-limited kinetics (or a combination), allowing the same structure to be utilized for compounds with different characteristics. The resulting model satisfactorily simulated blood concentration and tissue dosimetry data from multiple published single chemical rat studies. The model was then utilized to predict tissue kinetics for the jet fuel hearing loss study (JTEH A, 25:1-14). The model was also used to predict rat kinetic comparisons between hypothetical exposures to JP-8 or a Virent Synthesized Aromatic Kerosene (SAK):JP-8 50:50 blend at the occupational exposure limit (200 mg/m3). The array model has proven useful for comparing potential tissue burdens resulting from complex mixture exposures.

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A history and recent efforts of selected physiologically based pharmacokinetic modeling topics

Cited by 4 publications

References 89 publications

Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part III: Sheep and goat

Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part III: Sheep and goat

Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology

Complex Mixtures: Array PBPK Modeling of Jet Fuel Components

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