A Historical Perspective on Hyperthermia in Oncology

Seegenschmiedt, M. H.; Vernon, Clare C.

doi:10.1007/978-3-642-57858-8_1

Cited by 42 publications

(30 citation statements)

References 65 publications

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“…The original device has been ameliorated peculiarly on the electrode application and on matching EM wave between the two electrodes by Siemens Germany named Thermo flux (1910) where the two electrodes were hold by the therapist. This device was renewed, (Radiotherm, 1947) [7], when the electrode holders were applied. The method was unpopular, and forgotten.…”

Section: Hyperthermia Heating Equipment and Techniquesmentioning

confidence: 99%

“…The failures of radiotherapy on advanced disease, pushed Warren in 1935 to use a combination of ionizing radiation with an artificial systemic heating [6]. The data reported were interesting and 29 patients on 32 with advanced cancer experienced an immediate improvement of the general conditions and an increase in survival of 6 months All patients however experienced remission [6,7]. This interesting method of treatment (heat plus radiotherapy) was forgotten, until 1967, when Cavaliere and his group, in Rome successfully treated patients with hyperthermic limb perfusion [8] affected by metastatic melanoma and sarcoma.…”

Section: Introduction and Some Historical Notesmentioning

confidence: 99%

“…This interesting method of treatment (heat plus radiotherapy) was forgotten, until 1967, when Cavaliere and his group, in Rome successfully treated patients with hyperthermic limb perfusion [8] affected by metastatic melanoma and sarcoma. These researchers were the first to demonstrate some important aspects: 1st tumor cells in vitro are more sensitive than normal cells to heat; 2nd the amount of cells killed is proportional both to the length of exposure and to the degree of temperatures to which they are exposed [7].…”

Section: Introduction and Some Historical Notesmentioning

confidence: 99%

See 2 more Smart Citations

A Brief Overview of Hyperthermia in Cancer Treatment

Baronzio¹,

Parmar²,

Ballerini³

et al. 2014

J Integr Oncol

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Despite the large economic and intellectual efforts, cancer is still not easily treatable disease by conventional therapies. This led ultimately to reconsider hyperthermia, like one of interesting treatment methods connected to immunity and tumor metabolism. Hyperthermia has also the ability to play an additional role when used together with the conventional methods of treatment: surgery, radiotherapy, chemotherapy and immunotherapy. Recent trials in Holland and Germany have demonstrated that hyperthermia can prolong life and decrease disease re-appraisal when used in combination with radiotherapy and chemotherapy. Some tumors seem more responsive than others. In this brief summary we will attempt to give a vision of hyperthermia from a physical stand point, but more importantly we will give clinical and biological aspects. The results obtained in these trials on certain types of cancers such as cervix cancer, recurrent breast cancer and head neck cancer, melanoma, sarcomas, liver, glioblastoma and pancreatic cancer support the use of this technique, although some clinical and technical problems persist and have not been completely resolved.

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Section: Hyperthermia Heating Equipment and Techniquesmentioning

confidence: 99%

Section: Introduction and Some Historical Notesmentioning

confidence: 99%

Section: Introduction and Some Historical Notesmentioning

confidence: 99%

See 1 more Smart Citation

A Brief Overview of Hyperthermia in Cancer Treatment

Baronzio¹,

Parmar²,

Ballerini³

et al. 2014

J Integr Oncol

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“…The selection is realized by the applied radiative or field-conducted energy-transfer techniques. Both the heat therapy (thermal) and the electric field applications (nonthermal) have a long history [33,46]. The task of selection is definitely technical: to accurately deliver energy to deeply situated malignant tissues [37].…”

mentioning

confidence: 99%

Strong synergy of heat and modulated electromagnetic field in tumor cell killing

et al. 2009

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“…Diathermia is centered on the concept of heating by radiofrequency currents. The use of the temperature approach became robust when Siemens, one of the largest producers of electromagnetic devices at that time, marketed the first diathermia devices devoted to curing cancer [7]. This shift in thinking was easy; the explanations were clear enough.…”

Section: Introduction and Interpretation Of A Relative "Old Method" Imentioning

confidence: 96%