A histopathological evaluation and potential prognostic implications of oral squamous cell carcinoma with adverse features

Chang, Wei‐Chin; Chang, Ching-Fen; Li, Yu-Hsuan; Yang, Cheng‐Yu; Lin, Chih‐Kung; Chen, Yuan-Wu

doi:10.1016/j.oraloncology.2019.06.012

Cited by 36 publications

(42 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies have not distinguished blood vessel and lymphatic vessel well. 7,28,30 Furthermore, if separate estimates of lymphatic vessel or blood vessel invasion were reported as prognostic indicators, the outcomes might have been confused due to overlapping population. Therefore, we did not separate lymphatic invasion (LI) and vascular invasion (VI) to LVI in our meta-analyses.…”

Section: Discussionmentioning

confidence: 99%

Impact of lymphovascular invasion in oral squamous cell carcinoma: A meta-analysis

Huang

Zhu

Cai

et al. 2021

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of lymphovascular invasion in oral squamous cell carcinoma: A meta-analysis

Huang

Zhu

Cai

et al. 2021

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

View full text Add to dashboard Cite

show abstract

“…Various aspects of a tumor's morphology and growth pattern can be evaluated on hematoxylin and eosin (HE)-stained tumor sections. Several of these characteristics have been proposed as prognostic markers in oral cancer [4,9,10]. However, despite some reports of prognostic usefulness, none of these markers has been implemented in clinical practice, mostly due to lack of coherence between studies.…”

Section: Introductionmentioning

confidence: 99%

A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer

et al. 2020

View full text Add to dashboard Cite

We wanted to evaluate the prognostic value of common histopathological variables in a large cohort of patients with cancer in the mobile tongue as such information can be important for treatment stratification of the individual patient, especially for patients with low-stage disease. In addition, we wanted to investigate whether an alternative scoring model with fewer options would compromise the prognostic value. One hundred fifty patients with oral tongue squamous cell carcinomas that were treated in curative intent and with available HE-stained tumor sections were included. We reclassified all tumors and performed univariate and multivariate survival analyses of histopathological and clinical variables. For the complete cohort, lymph node status, grade of differentiation, perineural infiltration, and lymphocytic infiltration were independent prognosticators. In the low-stage disease group, independent prognostic factors were tumor size, grade of differentiation, and lymphocytic infiltrate. For patients with low-stage disease, a histo-score combining the scores for tumor differentiation and lymphocytic infiltrate identified a group of patients with particularly low survival, as patients with moderately or poorly differentiated tumors and little lymphocytic infiltrate had a less favorable 5-year survival outcome than patients in the high-stage disease group. This study shows that a histo-score combining tumor differentiation and lymphocytic infiltration should be given special consideration in treatment planning. Our results also illustrate that many variables can be scored with fewer options than previously suggested to increase their reproducibility, and still maintain their prognostic value.

show abstract

“…Poor tumor differentiation was indicated by a higher Ki-67 index, a higher SUV max value, and an enhanced invasion ability of cancer cells [24]. e frequency of LVI ranges from 10% to 81% in oral SCC, and LVI is significantly related to tumor primary size and pT stage [25].…”

Section: Discussionmentioning

confidence: 99%

Significance of SUV Max for Predicting Occult Lymph Node Metastasis and Prognosis in Early-Stage Tongue Squamous Cell Carcinoma

Seng

et al. 2020

Journal of Oncology

View full text Add to dashboard Cite

Objective. Our goal was to clarify the significance of SUV max for predicting occult lymph node metastasis and prognosis in early-stage tongue squamous cell carcinoma (SCC). Methods. cT1-2N0 tongue SCC patients who underwent a preoperative PET-CT examination were prospectively enrolled. The association between SUV max and occult lymph node metastasis was analyzed. The main study endpoint was locoregional control (LRC). The Cox model was used to determine the independent factors. Results. A total of 120 patients were included for analysis, and the median SUV max was 9.7. In 60 patients with an SUV max ≤9.7, 5 patients had occult metastasis; in 60 patients with an SUV max >9.7, 13 patients had occult metastasis, and the difference was significant (p=0.041). In patients with an SUV max ≤9.7, the 5-year LRC rate was 93%; in patients with an SUV max >9.7, the 5-year LRC rate was 81%, and the difference was significant (p=0.045). Conclusion. An SUV max >9.7 was a marker for occult lymph node metastasis and could decrease LRC in patients with cT1-2N0 tongue SCC.

show abstract

A histopathological evaluation and potential prognostic implications of oral squamous cell carcinoma with adverse features

Cited by 36 publications

References 49 publications

Impact of lymphovascular invasion in oral squamous cell carcinoma: A meta-analysis

Impact of lymphovascular invasion in oral squamous cell carcinoma: A meta-analysis

A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer

Significance of SUV Max for Predicting Occult Lymph Node Metastasis and Prognosis in Early-Stage Tongue Squamous Cell Carcinoma

Contact Info

Product

Resources

About