A histopathologic study of arthropod bite reactions in 20 patients highlights relevant adnexal involvement

Abstract

A practical histopathologic algorithm of arthropod bite recognition is proposed. The involvement of the sweat glands in the pattern of arthropod bite reaction is suggested as a new reliable diagnostic clue.

Dermatitis caused by arthropods in domestic environment: an Italian multicentre study

“…25 Gender distribution is influenced by the kind of work done, typically domestic in our study, as showed by the prevalent male involvement in occupational ectoparasitoses. 5,8,20,26 Moreover, cohabitants were affected regardless of gender, suggesting that arthropods indiscriminately attack humans in indoor environments. Personal history of atopy was not a risk factor for ectoparasitoses, being similar to general population.…”

“…The lesions generally persist for 2–10 days are usually itchy and painless and may result in temporary hyperpigmentation once they resolve; sequelae with necrotic, ecchymotic and hyperpigmented aspects are rare . The histology is usually characterized by eosinophilic spongiosis, exocytosis and possible vesicle formation with dermal lymphocytic and eosinophilic perivascular infiltrate . Pathological differential diagnoses include pseudolymphoma and some eosinophilic skin diseases, like urticarial vasculitis and Well's syndrome …”

“…18,19 The histology is usually characterized by eosinophilic spongiosis, exocytosis and possible vesicle formation with dermal lymphocytic and eosinophilic perivascular infiltrate. 20 Pathological differential diagnoses include pseudolymphoma and some eosinophilic skin diseases, like urticarial vasculitis and Well's syndrome. 21 Even if clinical picture and medical history are often suggestive for ectoparasitoses, there is actually no validated method to relate these diseases to specific arthropods.…”

Linfoma cutáneo primario de células B de la zona marginal (Primary cutaneous marginal zone lymphoma, PCMZL)

“…Este infiltrado puede extenderse hasta las glándulas sudoríparas, las glándulas sebáceas o los folículos pilosos 13 .…”

Imported fire ant envenomation: A clinicopathologic study of a recognizable form of arthropod assault reaction

“…Therefore, diagnosis of the causative organism is impossible due to the similarity of the reaction pattern, regardless of the insulting arthropod: epidermal spongiosis (eosinophilic spongiosis in particular), dermal edema with superficial and deep moderately dense infiltrate consisting of lymphocytes and eosinophils, involvement of adnexa, with interstitial eosinophils in the deep dermis. 1 There are cases in which identification of the causative organism based on pathological features is possible and in these cases the dermatopathologist should be aware of the pattern and attempt to advise the clinician of the source of the reaction. Examples include tick bites with retained mouth parts, scabies infestation with presence of mites or mite parts, spider bites with extensive necrosis and vasculopathic changes.…”