A histological study on the effect of noise on the adrenal cortex of adult male guinea pigs and the possible role of combined vitamins (A, C, and E) supplementation

Background: Modern society is full of stress. Immobilization stress is a model used in animals to study its effects. Vitamin E is an antioxidant that protects biological membranes from oxidative stress. Objectives: This study aimed to investigate the effects of immobilization stress on the adrenal cortex of rats and the ameliorative effect of vitamin E. Materials and Methods: Forty adult male rats were used in this study and were divided equally into 4 groups. Group I: were divided equally into negative and positive controls. Group II: rats received vitamin E at a dose of 40 I.U/kg by gastric tube for 30 days. Group III: rats subjected to immobilization stress 2 hours /day for 30 days. Group IV: rats subjected to immobilization stress 2 hours /day and received 40 I.U/kg of vitamin E for 30 days. Adrenal sections were histologically prepared and examined. Results: Group II was comparable to group IA. Group III revealed zona glomerulosa (ZG) with loss of normal architecture, zona fasciculata (ZF) with multiple cells containing cytoplasmic vacuolations and darkly stained nuclei. By EM ZG cells appeared with accumulations of lipid droplets and lysosomes, irregular nuclear envelopes and chromatin condensation. ZF cells showed numerous lipid droplets and irregular nuclear envelopes. There were significant increases in the mean area of collagen fibers and mean serum cortisol level. Group IV revealed regression of these changes and increase in the mean count of CD44 +ve cells. Conclusions: Immobilization stress exerted deleterious suprarenal cortical changes and vitamin E had an ameliorative effect.

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“…This congestion was attributed to an increase in ACTH, which stimulated the formation of prostaglandins leading to congestion [30] .…”

Section: Discussionmentioning

confidence: 99%

Light and electron microscopic study on the effect of immobilization stress on adrenal cortex of adult rats and possible ameliorative role of vitamin E.

Altayeb

Salem

2017

Journal of Medical Histology

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Plant-derived functional components: prevent from various disorders by regulating the endocrine glands

Khalid

Maqbool

Arshad

et al. 2022

International Journal of Food Properties

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Role of adrenal progenitor cells in the structural response of adrenal gland to various forms of acute stress and subsequent recovery in adult male albino rats

Sadek¹,

Abunasef²,

Khalil³

2023

J Microsc Ultrastruct

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A histological study on the effect of noise on the adrenal cortex of adult male guinea pigs and the possible role of combined vitamins (A, C, and E) supplementation

Cited by 3 publications

References 42 publications

Light and electron microscopic study on the effect of immobilization stress on adrenal cortex of adult rats and possible ameliorative role of vitamin E.

Light and electron microscopic study on the effect of immobilization stress on adrenal cortex of adult rats and possible ameliorative role of vitamin E.

Plant-derived functional components: prevent from various disorders by regulating the endocrine glands

Role of adrenal progenitor cells in the structural response of adrenal gland to various forms of acute stress and subsequent recovery in adult male albino rats

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