A highly sensitive assay for matrix metalloproteinase 2 via signal amplification strategy of eATRP

Wang, Qingyu; Liu, Jingliang; Yu, Shuaibing; Sun, Haobo; Wang, Lei; Li, Lianzhi; Kong, Jinming; Zhang, Xueji

doi:10.1016/j.microc.2021.106015

Cited by 6 publications

(2 citation statements)

References 30 publications

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“…Despite challenges like signal instability and background interference, these issues can be addressed through suitable substrates, probe design, and data analysis methods. 89,90 With continuous advancements and refinements in SERS technology, it is poised to become an indispensable tool for tumor research and early diagnosis. Its capabilities for detecting metabolites, and protein markers, and analyzing the ECM provide valuable information for understanding tumor biology and developing effective diagnostic and therapeutic strategies.…”

Section: Sers and Tmementioning

confidence: 99%

Advancing clinical cancer care: Unveiling the power of surface‐enhanced Raman spectroscopy

Li,

Yang,

Zhang

et al. 2024

J Raman Spectroscopy

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Tumors are characterized by abnormal cell growth, which leads to uncontrolled cell proliferation, invasion of surrounding tissues, and potential metastasis to other parts of the body. Current treatments for tumors include surgery, chemotherapy, radiotherapy, targeted therapy, and biological therapy. However, many tumors are detected at advanced stages, limiting the effectiveness of these treatments. Therefore, there is a need to develop more sensitive and efficient techniques to improve patient survival rates. Surface‐enhanced Raman scattering (SERS) technology is a highly sensitive molecular detection and characterization technique. It can be combined with histomorphology, immunolabeling assays, and molecular hybridization to achieve quantitative diagnosis at morphological, molecular, and genetic levels. SERS offers advantages such as objectivity, reproducibility, and comparability. However, there are challenges to address, including complex substrate or probe preparation, cumbersome data analysis, and signal reproducibility and reliability. To fully utilize the potential of SERS in the biomedical field and for clinical translation, it is important to optimize the technology and develop more sensitive, accurate, and reliable substrate or probe preparation and analysis methods. This review aims to comprehensively explain the mechanism and unique advantages of SERS technology and discuss its current status, challenges, and prospects in tumor‐related research.

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Section: Sers and Tmementioning

confidence: 99%

Advancing clinical cancer care: Unveiling the power of surface‐enhanced Raman spectroscopy

Li,

Yang,

Zhang

et al. 2024

J Raman Spectroscopy

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“…Working again with MMP-2 as analyte, Wang et al instead used the electrochemically mediated ATRP (eATRP) reaction in a signal amplification strategy with ferrocenylmethyl methacrylate monomers to obtain a chain-growth polymer of Fc as an electroactive probe [79]. A specific peptide used as a recognition substrate is cleaved in the presence of MMP-2, hence lowering the peak current of Fc measured with SWV.…”

Section: Peptides As Substrate and Signal Development Agents In Catalytic Biosensorsmentioning

confidence: 99%

The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics

et al. 2021

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Peptides represent a promising class of biorecognition elements that can be coupled to electrochemical transducers. The benefits lie mainly in their stability and selectivity toward a target analyte. Furthermore, they can be synthesized rather easily and modified with specific functional groups, thus making them suitable for the development of novel architectures for biosensing platforms, as well as alternative labelling tools. Peptides have also been proposed as antibiofouling agents. Indeed, biofouling caused by the accumulation of biomolecules on electrode surfaces is one of the major issues and challenges to be addressed in the practical application of electrochemical biosensors. In this review, we summarise trends from the last three years in the design and development of electrochemical biosensors using synthetic peptides. The different roles of peptides in the design of electrochemical biosensors are described. The main procedures of selection and synthesis are discussed. Selected applications in clinical diagnostics are also described.

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Metal-organic framework-encapsulated micellar silver nanoparticles for tumor microenvironment-adaptive electrochemical determination of matrix metalloproteinase-2

Wang

Sha

Mao

et al. 2022

Electrochimica Acta

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A highly sensitive assay for matrix metalloproteinase 2 via signal amplification strategy of eATRP

Cited by 6 publications

References 30 publications

Advancing clinical cancer care: Unveiling the power of surface‐enhanced Raman spectroscopy

Advancing clinical cancer care: Unveiling the power of surface‐enhanced Raman spectroscopy

The Role of Peptides in the Design of Electrochemical Biosensors for Clinical Diagnostics

Metal-organic framework-encapsulated micellar silver nanoparticles for tumor microenvironment-adaptive electrochemical determination of matrix metalloproteinase-2

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