A highly selective and sensitive “turn-on” fluorescent probe for rapid recognition and detection of Cu2+ in aqueous solution and in living cells

A novel hydrophilic fluorescent probe for Cu2+ detection and imaging in HeLa cells

“…The method for detecting Cu 2+ proposed in this work was compared with other previous works. [32][33][34][35][36][37][38] As shown in Table 1, the probe BNQ not only has a relatively lower detection limit, but also can detect Cu 2+ with shorter time and better water solubility. Therefore, the probe BNQ is a promising candidate to detect Cu 2+ in vivo and in vitro.…”

“…[28][29][30][31] Many recent reports describe excellent uorescent sensors for detecting Cu 2+ . [32][33][34][35][36][37][38] However, there are many unavoidable drawbacks for the probes that have been reported so far, such as weak hydrophilia, tedious synthetic steps, stringent applied conditions, and the likelihood of interference from Hg 2+ , Al 3+ , or Zn 2+ . Therefore, more research is required to develop uorescent probes with strong hydrophilia, good biocompatibility, low toxicity, high anti-interference ability, and easy preparation.…”

A highly selective fluorescence and absorption sensor for rapid recognition and detection of Cu2+ ions in aqueous solution and film

“…[ 2–7 ] In contrast, excessive Cu 2+ in the human body will cause aberrant nitrosative and oxidative stress and further lead to diseases such as Wilson’s disease and Alzheimer’s disease. [ 8,9 ] Therefore, the United States Environmental Protection Agency (US EPA) has limited the content of Cu 2+ ions in potable water to 1.3 mg/L. Normally, the concentration of Cu 2+ ions in soil or surface water ranges from 0.005 to 30 μg/L.…”

Synthesis Efforts of Acyclic Bis(monoalkylamino)maleonitriles and Macrocyclic Bis(dialkylamino)maleonitriles as Fluorescent Probes for Cations and a New Colorimetric Copper(II) Chemodosimeter

“…Figure 1 ), which showed a high copper(II) induced FE [5] . Nowadays, on the basis of the diaminomaleonitrile unit highly cation or anion selective colorimetric or fluorometric indicators were developed (Cu 2+ , [5–11] Hg 2+ , [12] Mn 2+ , [13] Zn 2+ , [13] Al 3+ , [14,15] Cd 2+ , [16] Fe 3+ , [17] F − , [18,19] OCl −[20–22] or CN −[23,24] ). Overall, diaminomaleonitrile based probes are suitable tools to detect cations or anions selectively [25] …”

“…Figure 2). In addition to it, we chose the diaminomaleonitrile unit as a receptor unit for cation complexation because of its potential to selectively bind transition metal ions [5–13,16,17] . Further, the diaminomaleonitrile is also a ‘push‐pull’ unit with electron‐withdrawing cyano groups and electron‐donating nitrogen atoms.…”