A high weekly dose of cholecalciferol and calcium supplement enhances weight loss and improves health biomarkers in obese women

Subih, Hadil S.; Zueter, Zainab; Obeidat, Bayan A.; Alqudah, Mohammad; Janakat, S; Hammoh, Fadwa; Sharkas, Ghazi; Bawadi, Hiba

doi:10.1016/j.nutres.2018.07.011

Cited by 21 publications

(9 citation statements)

References 25 publications

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“…In this line, a meta-analysis including 22 observational studies found that vitamin D supplementation was not found to significantly decrease percentage fat mass relative to placebo, despite the inverse relationship between 25(OH)D levels and percentage fat mass [78]. However, the combined action of vitamin D supplementation (cholecalciferol: 50,000 IU/subject/week) with calcium (1200 mg/calcium/subject/day) seems to increase weight loss and improve some blood metabolic profiles in obese women [79].…”

Section: Vitamin D and Obesity: Intervention Studiesmentioning

confidence: 99%

Mechanisms Involved in the Relationship between Vitamin D and Insulin Resistance: Impact on Clinical Practice

Contreras-Bolívar

García-Fontana

et al. 2021

Nutrients

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Recent evidence has revealed anti-inflammatory properties of vitamin D as well as extra-skeletal activity. In this context, vitamin D seems to be involved in infections, autoimmune diseases, cardiometabolic diseases, and cancer development. In recent years, the relationship between vitamin D and insulin resistance has been a topic of growing interest. Low 25-hydroxyvitamin D (25(OH)D) levels appear to be associated with most of the insulin resistance disorders described to date. In fact, vitamin D deficiency may be one of the factors accelerating the development of insulin resistance. Vitamin D deficiency is a common problem in the population and may be associated with the pathogenesis of diseases related to insulin resistance, such as obesity, diabetes, metabolic syndrome (MS) and polycystic ovary syndrome (PCOS). An important question is the identification of 25(OH)D levels capable of generating an effect on insulin resistance, glucose metabolism and to decrease the risk of developing insulin resistance related disorders. The benefits of 25(OH)D supplementation/repletion on bone health are well known, and although there is a biological plausibility linking the status of vitamin D and insulin resistance supported by basic and clinical research findings, well-designed randomized clinical trials as well as basic research are necessary to know the molecular pathways involved in this association.

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Section: Vitamin D and Obesity: Intervention Studiesmentioning

confidence: 99%

Mechanisms Involved in the Relationship between Vitamin D and Insulin Resistance: Impact on Clinical Practice

Contreras-Bolívar

García-Fontana

et al. 2021

Nutrients

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“…Besides the energy and fat/carbohydrate intake, of the frequently studied foods and nutrients, dairy foods and calcium (Ca) have received considerable attention, yet their roles have not been elucidated. Various research groups agreed that Ca (with or without vitamin D) improved weight and body fat outcomes in overweight/obese individuals [22,23,24,25,26,27]. Additionally, some studies showed that intervention with dairy foods have resulted in better weight loss or weight management than could be attributed to their Ca content [28] and performed better than Ca supplements [26].…”

Section: Introductionmentioning

confidence: 99%

Role of Calcium and Low-Fat Dairy Foods in Weight-Loss Outcomes Revisited: Results from the Randomized Trial of Effects on Bone and Body Composition in Overweight/Obese Postmenopausal Women

et al. 2019

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Several studies have investigated the possibility of dairy foods and calcium (Ca) mediating weight and body composition, but a consensus has not been reached. We aimed to investigate weight-loss-related outcomes during intervention with low-fat dairy foods or Ca + vitamin D supplements, both as complements to hypocaloric diets. Overweight/obese Caucasian, early-postmenopausal women (n = 135) were recruited for a 6 month energy-restricted weight loss study complemented with either low-fat dairy foods (D; 4–5 servings/day), or Ca + vitamin D supplements (S); both to amount a total of ~1500 mg/day and 600 IU/day of Ca and vitamin D, respectively, or placebo pills (C). Bone mineral density (BMD) and lean and fat tissue were measured by Lunar iDXA. Serum and urinary markers of bone turnover were analyzed. Diet and physical activity were assessed with 3-day records. Participants on average lost ~4%, ~3%, and ~2% of body weight, fat, and lean tissue, respectively. The significantly better outcomes were noticed in participants in the D group regarding body composition (fat loss/lean tissue preservation) and in participants in the S group regarding the BMD outcomes, compared to those in the C group. Therefore, increasing low-fat dairy foods to 4–5 servings/day and/or increasing Ca & vitamin D intake by supplements (in those who are at the borderline dietary intake) may be beneficial for weight loss/maintenance and may lead to more favorable bone and body composition outcomes in postmenopausal women during moderate weight loss.

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“…Our findings, however, strengthen the possibility that improvement of vitamin D status of children through supplementation and food fortification might work as well as, and even better than, a true vaccine. Some recent studies support this notion [54][55][56].…”

Section: Discussionmentioning

confidence: 82%

Modulating effect of vitamin D status on serum anti-adenovirus 36 antibody amount in children with obesity: National Food and Nutrition Surveillance

2020

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Background: The association of ADV-36 infection and obesity has been reported in children. The objective of this study was to examine the hypothesis that the association between ADV-36 infection and adiposity may be mediated by sub-optimal vitamin D status of the host. Methods: Ninety one apparently healthy children in different weight categories (normal weight: 33, overweight: 33, obesity: 25) aged 5-18 years were randomly selected from the registered population at National Food and Nutrition Surveillance Program (NFNS). The groups were matched based on age and sex. Anthropometric, biochemical and serological assessments were performed. Results: The amount of anti-ADV36-Ab increased whereas circulating concentrations of 25(OH) D decreased across BMI categories with higher amounts in children with normal weight than in children with overweight and obesity (31.0 ± 16.4, 22.5 ± 10.5 and 21.9 ± 9.8 nmol/L, respectively, p = 0.004). Logistic regression analysis revealed that for each unit increment of anti-ADV36-Ab, the chance of increase in weight was 8.5 times (OR: 8.5, p = 0.029). Interestingly, when 25(OH) D was introduced into the model, anti-ADV36-Ab was no longer the predictor of weight increment and the chance of increase in weight reduced 5% for each unit increase in 25(OH) D concentration (OR: 0.95, p = 0.012). Conclusion: It is suggested that ADV36-induced lipogenesis may be mediated by vitamin D deficiency in children with obesity.

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A high weekly dose of cholecalciferol and calcium supplement enhances weight loss and improves health biomarkers in obese women

Cited by 21 publications

References 25 publications

Mechanisms Involved in the Relationship between Vitamin D and Insulin Resistance: Impact on Clinical Practice

Mechanisms Involved in the Relationship between Vitamin D and Insulin Resistance: Impact on Clinical Practice

Role of Calcium and Low-Fat Dairy Foods in Weight-Loss Outcomes Revisited: Results from the Randomized Trial of Effects on Bone and Body Composition in Overweight/Obese Postmenopausal Women

Modulating effect of vitamin D status on serum anti-adenovirus 36 antibody amount in children with obesity: National Food and Nutrition Surveillance

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