A high throughput approach to purifying chiral molecules using 3μm analytical chiral stationary phases via supercritical fluid chromatography

Supercritical fluid chromatography for the enantioseparation of pharmaceuticals

“…Hamman et al [124] developed a high-throughput screening approach for SFC, using six columns in the following sequence: Chiralpak ® AD-H, Lux ® Cellulose-1, Chiralcel ® OJ-H, Chiralpak ® IC, Chiralpak ® AS-H and Lux ® Cellulose-4. For screening, a 2.5 min gradient is used, starting with a linear increase from 10% to 55% modifier over 1.5 min and maintaining 55% modifier for one min.…”

Performance comparison of chlorinated chiral stationary phases in supercritical fluid chromatography for separation of selected pyrrolidone derivatives

“…Since 2010, there were some studies concerning the use of chiral columns packed with smaller particles [[27], [28], [29], [30], [31], [32], [33]]. The mean diameter or particle size (d p ), of the spherical supports used for the stationary phase of a column is a physical dimension that has a significant impact on the performance of the column.…”

Development and validation of a supercritical fluid chromatography method for the direct determination of enantiomeric purity of provitamin B5 in cosmetic formulations with mass spectrometric detection

“…There were few investigations on the impact of 3 m CSP particles to speed up analysis maintaining resolution [17,18]. For the particular case of panthenol, in the selected operating conditions, some decrease in the flow rate was found to increase efficiency.…”