A high-sensitivity high-resolution intravascular photoacoustic catheter through mode cleaning in a graded-index fiber

Yuan, Yuhao; Zhang, Guangju; Chen, Yuqi; Ni, Hongli; Li, Mingsheng; Sturek, Michael; Cheng, Ji‐Xin

doi:10.1016/j.pacs.2023.100451

Cited by 3 publications

(2 citation statements)

References 47 publications

(51 reference statements)

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“…Cheng et al reported an intravascular PA catheter with a self-cleaning mode in a graded-index fiber, which improved the beam quality and the sensitivity for lipid identification. The spatial resolution and detection sensitivity were significantly enhanced using the lower-order modes specially designed to have a self-cleaning effect in the graded-index fiber [80]. Third, although differentiating among different plaque types is critical for targeted treatment, there are challenges in achieving precise classification.…”

Section: Discussionmentioning

confidence: 99%

Multimodal photoacoustic imaging in analytic vulnerability of atherosclerosis

Zhou,

Chen,

et al. 2023

iRADIOLOGY

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Atherosclerosis is a major cause of mortality and morbidity, and rupture can lead to myocardial infarction and stroke. The vulnerability assessment of atherosclerosis plaques is important for providing medical treatment. Identifying vulnerable plaques requires noninvasive, high‐resolution imaging techniques for capturing and locating high‐risk markers. Photoacoustic imaging (PAI) is a hybrid and novel imaging modality that uses nonionizing excitation and has substantial promise for vulnerability assessment of atherosclerosis. The current review examined current applications of multimodal PAI for identification of atherosclerosis plaques. Furthermore, we discuss the challenges and limitations in the implementation this method and future research directions to overcome these difficulties. First, we discuss two aspects of vulnerable plaque characterization: large necrotic cores and thin degraded cap component identification. Then, we then discuss applications of high‐risk plaque characterization, including intraplaque hemorrhage and heme degradation markers detection. We hope that this review will shed light on the potential application of optical imaging techniques in atherosclerosis identification and facilitate further studies that will ultimately lead to the broader application of multimodal PAI in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Multimodal photoacoustic imaging in analytic vulnerability of atherosclerosis

Zhou,

Chen,

et al. 2023

iRADIOLOGY

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“…Currently, IVPA is still a preclinical technology, as the integration of adequate light delivery and sensitive PA detection in a small (1 mm outer diameter) is proving to be challenging. Many catheter designs have been published 211 – 216 but to date, none of these have been clinically evaluated. The requirements on the light source (wavelength, pulse energy, and repetition frequency) have also required the engineering of custom laser systems 19 , 152 , 217 …”

Section: Clinical and Translational Researchmentioning

confidence: 99%

Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine

2023

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Photoacoustic imaging (PAI) enables the visualization of optical contrast with ultrasonic imaging. It is a field of intense research, with great promise for clinical application. Understanding the principles of PAI is important for engineering research and image interpretation.Aim: In this tutorial review, we lay out the imaging physics, instrumentation requirements, standardization, and some practical examples for (junior) researchers, who have an interest in developing PAI systems and applications for clinical translation or applying PAI in clinical research.Approach: We discuss PAI principles and implementation in a shared context, emphasizing technical solutions that are amenable to broad clinical deployment, considering factors such as robustness, mobility, and cost in addition to image quality and quantification.Results: Photoacoustics, capitalizing on endogenous contrast or administered contrast agents that are approved for human use, yields highly informative images in clinical settings, which can support diagnosis and interventions in the future.Conclusion: PAI offers unique image contrast that has been demonstrated in a broad set of clinical scenarios. The transition of PAI from a "nice-to-have" to a "need-to-have" modality will require dedicated clinical studies that evaluate therapeutic decision-making based on PAI and consideration of the actual value for patients and clinicians, compared with the associated cost.

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Perspectives on endoscopic functional photoacoustic microscopy

Yang,

2024

Applied Physics Letters

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Endoscopy, enabling high-resolution imaging of deep tissues and internal organs, plays an important role in basic research and clinical practice. Recent advances in photoacoustic microscopy (PAM), demonstrating excellent capabilities in high-resolution functional imaging, have sparked significant interest in its integration into the field of endoscopy. However, there are challenges in achieving functional PAM in the endoscopic setting. This Perspective article discusses current progress in the development of endoscopic PAM and the challenges related to functional measurements. Then, it points out potential directions to advance endoscopic PAM for functional imaging by leveraging fiber optics, microfabrication, optical engineering, and computational approaches. Finally, it highlights emerging opportunities for functional endoscopic PAM in basic and translational biomedicine.

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A high-sensitivity high-resolution intravascular photoacoustic catheter through mode cleaning in a graded-index fiber

Cited by 3 publications

References 47 publications

Multimodal photoacoustic imaging in analytic vulnerability of atherosclerosis

Multimodal photoacoustic imaging in analytic vulnerability of atherosclerosis

Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine

Perspectives on endoscopic functional photoacoustic microscopy

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