1995
DOI: 10.1007/bf00303257
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A High-resolution map of 1.6 Mb in the Down syndrome region: a new map between D21S55 and ETS2

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Cited by 11 publications
(4 citation statements)
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“…3). An accurate human physical map is available for the region between human CBR and ETS2 (Ichikawa et al 1993;DufresneZacharia et al 1994;Patil et al 1994;Gosset et al 1995;Osoegawa et al 1996;Ohira et al 1997). Distances on the human and mouse physical maps are well-conserved between CBR1 and ETS2.…”
Section: Discussionmentioning
confidence: 99%
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“…3). An accurate human physical map is available for the region between human CBR and ETS2 (Ichikawa et al 1993;DufresneZacharia et al 1994;Patil et al 1994;Gosset et al 1995;Osoegawa et al 1996;Ohira et al 1997). Distances on the human and mouse physical maps are well-conserved between CBR1 and ETS2.…”
Section: Discussionmentioning
confidence: 99%
“…Where gene orientation has been determined, an arrowhead indicates the direction of transcription. The consensus human physical map was compiled from several sources (Burmeister et al 1991;Chumakov et al 1992;Ichikawa et al 1993;Dufresne-Zacharia et al 1994;Patil et al 1994;Gardiner et al 1995;Gosset et al 1995;Korenberg et al 1995;Cabin et al 1996;Osoegawa et al 1996;Hubert et al 1997;Ohira et al 1997). With the exception of D21S15 and D21S349, the markers shown above the scale bar are known transcripts.…”
Section: ‫72מ‬mentioning
confidence: 99%
“…Furthermore, the histological similarity between Wolfflin nodules and Brushfield spots (Donaldson, 1961; Jaeger, 1980), and the fact that the position and appearance of Brushfield spots for patients with Down’s syndrome can be quite similar to what is seen in normal controls (Figure 2C), suggests that the region on chromosome 21 that has been associated with Brushfield spots (Delabar et al., 1993), may also holds candidates genes for Wolfflin nodules. The genes ERG (Rao et al., 1987), ETS2 (Boulukos et al., 1988), HMG (Landsman et al., 1989), MX1 (Horisberger et al., 1988), WRB (Egeo et al., 1998), DSCR1 (Fuentes et al., 1995), and SH3BGR (Vidal‐Taboada et al., 1997) as well as other genes which map to this region (Gosset et al., 1995), could from this perspective be potential candidate genes for Wolfflin nodules. However, normal individuals that do have mutations in some of these genes, do not always have Wolfflin nodules or Brushfield spots, indicating that the appearance of Wolfflin nodules depend on the interaction between several genes.…”
Section: Wolfflin Nodulesmentioning
confidence: 99%
“…The DCR is located around the 21q22.2 sub-band on the distal part of the long arm, contains probe D21S55, and is flanked by probes D21S17 and ERG (1)(2)(3). To facilitate analysis of this region, a genomic and yeast artificial chromosome (YAC) physical map spanning 3.8 Mb of DNA was recently established (4,5).…”
mentioning
confidence: 99%