A high prevalence of new onset otitis media during parent diagnosed common colds

Winther, Birgit; Doyle, William J.; Alper, Cüneyt M.

doi:10.1016/j.ijporl.2006.05.011

Cited by 23 publications

(24 citation statements)

References 21 publications

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“…Nonethe-less, given that most OM episodes are temporally related to an existing CLI 8,12 , that many of the OM "risk factors" predict CLI incidence and prevalence and, as shown by our results, that the incidence and prevalence of OM track those for a CLI, we believe that data for CLIs need be included in any analyses that focus on identifying independent "risk factors" for AOM, OME or OM. Incidence of AOM (closed circles, unilateral or bilateral), OME (open squares, unilateral or bilateral) and CLIs (solid line) in the study population as a function of study week.…”

Section: Discussionmentioning

confidence: 62%

The incidence, prevalence and burden of OM in unselected children aged 1–8 years followed by weekly otoscopy through the “common cold” season

Mandel

Doyle

Winther

et al. 2008

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 62%

The incidence, prevalence and burden of OM in unselected children aged 1–8 years followed by weekly otoscopy through the “common cold” season

Mandel

Doyle

Winther

et al. 2008

International Journal of Pediatric Otorhinolaryngology

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“…Viral upper respiratory tract infection (URI) has been shown to precede most cases of AOM 1,2. Viral URI leads to Eustachian tube inflammation resulting in its dysfunction and negative middle ear pressure permitting secretions containing the infecting virus and pathogenic bacteria that colonize the nasopharynx to enter the middle ear 3,4.…”

Section: Introductionmentioning

confidence: 99%

Clinical Spectrum of Acute Otitis Media Complicating Upper Respiratory Tract Viral Infection

Kalu¹,

Ataya²,

McCormick³

et al. 2011

Pediatric Infectious Disease Journal

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“…Since it has been shown that URI precedes AOM [15,26,27], preventive efforts need to detail the immunological events that affect the transition from URI to AOM. Identification of important genetic markers might support focused approaches to prevent and manage AOM in children whose genetic biomarkers indicate they are at risk.…”

Section: Discussionmentioning

confidence: 99%

Acute otitis media severity: Association with cytokine gene polymorphisms and other risk factors

McCormick

Grady

Diego

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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Background We have previously shown an association between polymorphisms of proinflammatory cytokine genes and susceptibility to upper respiratory tract infection and acute otitis media. It has not been known whether polymorphisms or risk factors are associated with the severity of acute otitis media. Objective To evaluate the influences of proinflammatory cytokine gene polymorphisms and other risk factors on severity of acute otitis media following upper respiratory infection. Methods In a prospective, longitudinal study, children aged 6-35 months were followed for one year for occurrences of upper respiratory tract infection and acute otitis media. Children were studied for TNFα-308, interleukin (IL)- 6-174 and IL-1 ß+3953 polymorphisms, taking into account age, gender, race, family history of otitis, tobacco smoke exposure, breast feeding, day of upper respiratory tract infection at the time of diagnosis and pneumococcal vaccine status. Symptoms and signs of acute otitis media were graded according to a validated scale. The association between acute otitis media clinical severity, polymorphic genotypes, and risk factors was analyzed using statistical models that account for multiple episodes of acute otitis media per child. Results A total of 295 episodes of acute otitis media in 128 subjects were included. More severe acute otitis media symptoms were associated with young age (P=0.01), family history of acute otitis media (P=0.002), tobacco smoke exposure (P=0.008), and early diagnosis of otitis after onset of upper respiratory tract infection (P=0.02). Among children with a bulging or perforated tympanic membrane (206 episodes, 104 subjects), those who had the IL- 1 ß+3953 polymorphism, experienced higher symptom scores (P<0.02). Conclusion This is the first report of the association between risk factors and acute otitis media severity. Risk factors such as tobacco smoke exposure and a positive family history appear to be more significantly associated with acute otitis media severity than proinflammatory gene polymorphisms. Clinical severity may be an important factor contributing to the incidence and costs of acute otitis media, because children with more severe symptoms might be more likely to be brought for a medical visit, receive a diagnosis of acute otitis media, and be prescribed an antibiotic.

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A high prevalence of new onset otitis media during parent diagnosed common colds

Cited by 23 publications

References 21 publications

The incidence, prevalence and burden of OM in unselected children aged 1–8 years followed by weekly otoscopy through the “common cold” season

The incidence, prevalence and burden of OM in unselected children aged 1–8 years followed by weekly otoscopy through the “common cold” season

Clinical Spectrum of Acute Otitis Media Complicating Upper Respiratory Tract Viral Infection

Acute otitis media severity: Association with cytokine gene polymorphisms and other risk factors

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