A high expression of cell adhesion molecule 1 (CADM1) is an unfavorable prognostic factor in mycosis fungoides

Mashima, Emi; Sawada, Yu; Yamaguchi, Takashi; Yoshioka, Haruna; Ohmori, Shun; Haruyama, Sanehito; Yoshioka, Manabu; Okada, Etsuko; Nakamura, Motonobu

doi:10.1016/j.clim.2018.01.005

Cited by 13 publications

(15 citation statements)

References 13 publications

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“…In our small series of SS patients, CADM1 expression was observed in patients with progressive SS: four of five SS patients harboring CADM1+ cells that made up over 20% of the CD3+CD4+ fraction died of progressive SS within 1.5 years after the appearance of more than 20% of CADM1+ cells. Similar to our observations, recent reports have described that CADM1 is expressed in the cutaneous infiltrates of MF, and its expression might be related to the poor prognosis . Therefore, further cohort study is required to address whether CADM1 expression is a marker of progressive MF and SS.…”

Section: Discussionsupporting

confidence: 88%

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The expression of cell adhesion molecule 1 and its splicing variants in Sézary cells and cell lines from cutaneous T‐cell lymphoma

Yamaguchi

Morizane

Hamada

et al. 2019

The Journal of Dermatology

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Cell adhesion molecule 1 (CADM1) is aberrantly expressed by T‐cell neoplasms such as adult T‐cell leukemia/lymphoma (ATLL) and mycosis fungoides (MF). We studied the expression of CADM1 and its splicing variants in Sézary syndrome (SS), MF, other cutaneous T‐cell lymphoma (CTCL), and cell lines derived from T‐ and B‐cell lymphomas. Soluble CADM1 was measured in the patients’ sera. CADM1+ cells in the blood and skin lesions were examined by flow cytometry and immunostaining, respectively. Soluble CADM1 was measured by ELISA, and the splicing variants of CADM1 transcripts were determined by reverse transcriptase‐polymerase chain reaction, followed by sequencing. As a result, circulating CADM1+ cells were significantly increased in seven out of 10 patients with SS, ranging from 7.9% to 74.5% of the CD3+CD4+ fractions (median 33.7%; cut‐off value 6.5%). The percentages of CADM1+ cells were usually less than those of circulating Sézary cells. CADM1 was expressed, to various degrees, in six of nine T‐cell lines derived from SS, MF, ATLL, and anaplastic large cell lymphoma (ALCL), but negative in B‐cell lymphoma‐derived cell lines. CADM1+ cells were present in the skin infiltrates of MF, SS, ATLL and ALCL. Serum levels of soluble CADM1 were not significantly elevated in SS/MF. Three major splicing variants of CADM1 expressed by neoplastic T‐cells contained different combinations of the exons 7, 8, 9 and 11, including a putative oncogenic variant composed of exons 7‐8‐9‐11. In conclusion, CADM1 is frequently expressed in Sézary cells and cell lines from CTCL.

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Section: Discussionsupporting

confidence: 88%

“…Similar to our observations, recent reports have described that CADM1 is expressed in the cutaneous infiltrates of MF, and its expression might be related to the poor prognosis. 14,15 Therefore, further cohort study is required to address whether CADM1 expression is a marker of progressive MF and SS.…”

Section: Discussionmentioning

confidence: 99%

The expression of cell adhesion molecule 1 and its splicing variants in Sézary cells and cell lines from cutaneous T‐cell lymphoma

Yamaguchi

Morizane

Hamada

et al. 2019

The Journal of Dermatology

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“…Contrarily to solid tumors, nonsolid tumors such as mycosis fungoides and adult T-cell leukemia/lymphoma [ 33 , 34 , 35 , 36 ] showed that high expression of CADM1 had an unfavorable clinical behavior [ 17 , 29 , 37 ]. In nonsolid tumors, CADM1 contributes to the invasion of the tumor into vessels and other organs, suggesting that the prognostic significance of CADM1 is different in the types of tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Immunochemical staining for CADM1 was conducted using a CADM1 monoclonal antibody (mAb, Lifespan Bioscience, Inc., Seattle, WA, USA) on formalin-fixed, paraffin-embedded specimens [ 17 ]. In brief, specimens were cut into 4-μm-thick sections and then deparaffinized in xylene and dehydrated through graded alcohol solutions.…”

Section: Methodsmentioning

confidence: 99%

“…The specimens were digitized using the Nano Zoomer Digital Pathology C9600 system (Hamamatsu Photonics, Hamamatsu, Japan). Analysis of the expression intensity in histological specimens was performed using the following processes, as described previously [ 17 , 18 , 19 , 20 ]. The results were exported to JPG files and were opened in Adobe Photoshop CS(J) (Adobe Systems, Inc., San Jose, CA, USA).…”

Section: Methodsmentioning

confidence: 99%

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Cell Adhesion Molecule 1 (CADM1) Is an Independent Prognostic Factor in Patients with Cutaneous Squamous Cell Carcinoma

et al. 2021

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Cell adhesion molecular 1 (CADM1) is a multifunctional cell adhesion molecule belonging to the immunoglobulin superfamily, which suppresses malignant solid tumor development. However, the correlation between CADM1 expression and prognosis in cutaneous squamous cell carcinoma (cSCC) patients remains unclear. In a retrospective analysis of 88 patients diagnosed with cSCC at our institution between January 2006 and December 2016, the degree of CADM1 expression in tumor cells was evaluated by immunostaining. Fifty-five and 33 patients had tumors with high and low CADM1 expression, respectively. Low CADM1 expression on the tumor was associated with poor differentiation, whereas the Kaplan–Meier curve and log-lank test indicated a favorable prognosis with high CADM1 expression. Multivariate analysis excluding the effect of the degree of differentiation and clinical stages showed that the hazard ratio (HR) of survival was significantly increased with low CADM1 expression. Thus, CADM1 expression is an independent prognostic factor for cSCC patients.

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Cell adhesion molecule 1 expression in mycosis fungoides versus parapsoriasis versus inflammatory dermatosis: an immunohistochemical comparative study

Neinaa

El-Maadawy

Atteia³

et al. 2023

Arch Dermatol Res

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A high expression of cell adhesion molecule 1 (CADM1) is an unfavorable prognostic factor in mycosis fungoides

Cited by 13 publications

References 13 publications

The expression of cell adhesion molecule 1 and its splicing variants in Sézary cells and cell lines from cutaneous T‐cell lymphoma

The expression of cell adhesion molecule 1 and its splicing variants in Sézary cells and cell lines from cutaneous T‐cell lymphoma

Cell Adhesion Molecule 1 (CADM1) Is an Independent Prognostic Factor in Patients with Cutaneous Squamous Cell Carcinoma

Cell adhesion molecule 1 expression in mycosis fungoides versus parapsoriasis versus inflammatory dermatosis: an immunohistochemical comparative study

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