A hemolytic anti‐<scp>LKE</scp> associated with a rare <scp>LKE</scp>‐negative, “weak <scp>P</scp>” red blood cell phenotype: alloanti‐<scp>LKE</scp> and alloanti‐<scp>P</scp> recognize galactosylgloboside and monosialogalactosylgloboside (<scp>LKE</scp>) antigens

Cooling, Laura; Dake, Louann R.; Haverty, Donna; Mullis, N.C.; Ellis, Susie; Shayman, James A.; Judd, W. John

doi:10.1111/trf.12772

Cited by 4 publications

(6 citation statements)

References 50 publications

(185 reference statements)

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“…One major issue with the latter study was its dependence on flow cytometry to identify Gb4. ACHN cells, for example, express Gb4, Gb5, and MSGG/LKE (363,389). As noted above, B19 can bind Gb5 and MSGG, and Gb5 inhibits B19-associated hemagglutination in vitro (368,484).…”

Section: Parvovirus B19mentioning

confidence: 89%

“…LKE-negative individuals may also be at increased risk, assuming that elevated Gb3 expression is also present on nonerythroid tissues such as the endothelium (350,360). It should be noted that many Stx-sensitive immortalized cell lines (for example, ACHN, Caco-2, and Daudi) possess a "P k -like" phenotype where Gb3 Ͼ Ͼ Gb4 (363,387,448).…”

Section: Shigella Enterohemorrhagic E Coli and Shiga Toxinsmentioning

confidence: 99%

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Blood Groups in Infection and Host Susceptibility

2015

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SUMMARY Blood group antigens represent polymorphic traits inherited among individuals and populations. At present, there are 34 recognized human blood groups and hundreds of individual blood group antigens and alleles. Differences in blood group antigen expression can increase or decrease host susceptibility to many infections. Blood groups can play a direct role in infection by serving as receptors and/or coreceptors for microorganisms, parasites, and viruses. In addition, many blood group antigens facilitate intracellular uptake, signal transduction, or adhesion through the organization of membrane microdomains. Several blood groups can modify the innate immune response to infection. Several distinct phenotypes associated with increased host resistance to malaria are overrepresented in populations living in areas where malaria is endemic, as a result of evolutionary pressures. Microorganisms can also stimulate antibodies against blood group antigens, including ABO, T, and Kell. Finally, there is a symbiotic relationship between blood group expression and maturation of the gastrointestinal microbiome.

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Section: Parvovirus B19mentioning

confidence: 89%

Section: Shigella Enterohemorrhagic E Coli and Shiga Toxinsmentioning

confidence: 99%

Blood Groups in Infection and Host Susceptibility

2015

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“…After the identification of the glycosphingolipid (GSL) globoside as the P‐antigen, Schwarting and colleagues used purified globoside and Forssmann antigen to inhibit antibody‐mediated hemolysis. A more recent article demonstrated direct binding of PCH serum to purified globoside and RBC neutral GSLs by thin‐layer chromatography . Although anti‐P IgG is the most common antibody encountered in PCH, there are PCH cases with biphasic IgM and IgA antibodies, and other carbohydrate specificities (I, i, HI, Pr) …”

mentioning

confidence: 99%

Kids, colds, and complement: paroxysmal cold hemoglobinuria

Cooling

2017

Transfusion

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“…The rates are estimated between 1 and 3% in patients that receive episodic transfusions, while for patients who receive chronic blood transfusions like patients with SCD and MDS, rates vary between 8 and 76% [9][10][11][12]. Although the most commonly observed alloantibodies of clinical relevance are against antigens belonging to RH (D, C, c, E, e), KEL (K, k, Js a , Kp a ), JK (Jk a , Jk b ), FY (Fy a , Fy b ), and MNS (M, S, s) blood group systems [9], alloantibodies against Rh variants [13][14][15] and other rare blood group phenotypes have also been implicated in shortened survival of transfused RBCs by causing DHTR [13,16] or HDFN [17]. In addition, some antibodies only have occasional reports of being clinically significant, that is, anti-Yt a , -Ge, and -N or have no clinical significance unless reactive at 37°C, that is, anti-Le a , -Le b , -M, -N, -P1, -Lu b , -A1, and -Bg [18].…”

Section: Blood Transfusion and Risk Of Rbc Alloimmunizationmentioning

confidence: 99%

Accuracy of Blood Group Typing in the Management and Prevention of Alloimmunization

Sippert¹,

Volkova²,

Rios³

2021

Human Blood Group Systems and Haemoglobinopathies

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Blood transfusion is an effective therapeutic approach for several hematological conditions including sickle cell disease (SCD), thalassaemia, myelodysplastic syndrome (MDS), and autoimmune hemolytic anemia. It is also often indicated for transplantation and for patients receiving medical treatments for cancer. However, transfusion treatment can lead to the red blood cell (RBC) alloimmunization when an incompatible antigen is inadvertently present in the transfused blood. Alloantibodies can cause RBC destruction and many other complications defeating the purpose of the treatment. The risk of development of multiple alloantibodies increases with the frequency of transfusions in transfusion-dependent patients and can be mitigated by transfusing blood type negative for multiple antigens to prevent hemolysis. This chapter discusses the transfusion's risk of RBC alloimmunization as an adverse event; consequences of alloimmunization in patients' care; approaches to prevent and/or mitigate alloimmunization and enhance transfusion efficacy; application of RBC genotyping to supplement serology for preventing alloimmunization. The currently available techniques for RBC genotyping and the importance of reference reagents for determining the genotyping accuracy will also be discussed.Accuracy of Blood Group Typing in the Management and Prevention of Alloimmunization DOI: http://dx.doi.org/10.5772/intechopen.90095 Blood group system WHO IRR [98] CBER RR [89]Rh RHD positive (zygosity not determined)

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A hemolytic anti‐LKE associated with a rare LKE‐negative, “weak P” red blood cell phenotype: alloanti‐LKE and alloanti‐P recognize galactosylgloboside and monosialogalactosylgloboside (LKE) antigens

Abstract: We describe the first example of a clinically significant anti-LKE in the setting of a rare weak P background. Human alloanti-LKE and some alloanti-P recognized Gb5 and MSGG.

Cited by 4 publications

References 50 publications

Blood Groups in Infection and Host Susceptibility

Blood Groups in Infection and Host Susceptibility

Kids, colds, and complement: paroxysmal cold hemoglobinuria

Accuracy of Blood Group Typing in the Management and Prevention of Alloimmunization

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