1948
DOI: 10.1084/jem.88.5.503
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A Hemolysin Associated With the Mumps Virus

Abstract: 1. A factor capable of causing the hemolysis of the erythrocytes of man, chicken, and sheep occurs in the amniotic and allantoic fluids of chick embryos infected with the virus of mumps. 2. The hemolysin has not been found in normal fluids or in those infected with PR8 or Lee B strains of influenza virus. 3. The hemolysin is definitely inhibited by the serum of man and monkey convalescent from mumps, but only slightly by the serum of the acute phase. 4. The hemolysi… Show more

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Cited by 44 publications
(11 citation statements)
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“…Also, the haemolytic assays with these strains suggest that EDS-76 virus does not possess the ability to haemolyse red cells like members of the paramyxovirus group (Morgan et at., 1948). Baxendale (1978a) first reported the experimental reproduction of the egg drop syndrome (1976) using the BC14 strain.…”
Section: Discussionmentioning
confidence: 99%
“…Also, the haemolytic assays with these strains suggest that EDS-76 virus does not possess the ability to haemolyse red cells like members of the paramyxovirus group (Morgan et at., 1948). Baxendale (1978a) first reported the experimental reproduction of the egg drop syndrome (1976) using the BC14 strain.…”
Section: Discussionmentioning
confidence: 99%
“…The infection of cells by MuV is initiated by the binding of the hemagglutinin-neuraminidase glycoprotein (HN), a type II mem-brane protein, to sialic acids of cell surface macromolecules (10). MuV has been shown to bind to erythrocytes from different mammalian and avian species (11)(12)(13)(14)(15), but the binding activity of MuV HN has not been studied in detail. Sialic acids present in ␣2-3, ␣2-6, and/or ␣2-8 linkages may serve as receptor determinants for MuV.…”
mentioning
confidence: 99%
“…This is a novel serologic reaction, which, on further analysis, may provide more insight into the mechanisms of serologic hemolysis. It is possible that this phenomenon is related, at least in principle, to the leucocytolytic effect of a combination of tuberculin, a component of the euglobulin fraction of tuberculous sera and complement, as described by Favour and his associates (9,10).4 4 It is apparently unrelated to the recently described lysis of red cells by viruses which can occur in the absence of complement and is inhibited by specific antibody against a component of the virus particle (11,12).…”
Section: Discussionmentioning
confidence: 97%