A Guinea-Pig Model in Burn Research

Nicolai, J. P. A.; Goris, R.J.A.

doi:10.1159/000128106

Cited by 7 publications

(8 citation statements)

References 7 publications

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“…Several animal models have been used with success, to study the effects of growth factors on dermal wound healing. These models include mice,1, 11–15 rats,5, 14, 16–20 rabbits,12, 21–25 guinea pigs,3, 11, 15, 17, 26–35 and pigs 11, 30, 36–40. When choosing a laboratory animal for a dermal wound healing study, one has to consider certain aspects, which are associated with a particular animal.…”

Section: Introductionmentioning

confidence: 99%

“…A variety of wound types have been used in dermal wound‐healing research. These can be divided into incisional wounds, which are closed after wounding,14, 16, 18, 25 or excisional wounds 1, 3, 5, 11–15, 17–24, 26–29, 31–40. The method of creation of the wound can also vary.…”

Section: Introductionmentioning

confidence: 99%

“…The method of creation of the wound can also vary. Wounds were created surgically,1, 11, 14, 18, 19, 21, 25–28, 30, 38–40 with a punch biopsy,3, 11–13, 15, 20, 22, 24, 29, 35, 37 or thermally; these were either contact burns,14, 23, 33, 34, 36 scald burns,17, 31, 36 or radiation‐induced burns 12. The size of the wounds also varied, from 3–8 mm3, 11, 12, 15, 20, 22, 24, 29, 35, 37 to 5–6 cm 11, 14, 16, 18, 25–27.…”

Section: Introductionmentioning

confidence: 99%

“…11,30,36 -40 When choosing a laboratory animal for a dermal wound healing study, one has to consider certain aspects, which are associated with a particular animal. Guinea pigs 31 and pigs 11,36,37 were documented to have an epidermis and dermis that have more similarities with human skin than other animals.…”

Section: Introductionmentioning

confidence: 99%

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Transforming growth factor‐β3–loaded microtextured membranes for skin regeneration in dermal wounds

Vooijs

Walboomers

Parker

et al. 2004

J Biomedical Materials Res

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Adverse effects of wound healing, such as excessive scar tissue formation, wound contraction, or nonhealing wounds represent a major clinical issue in today's healthcare. Transforming growth factor (TGF)-beta3 has specifically been implicated in wound healing. Our hypothesis was that local administration of TGF-beta3 to excisional dermal wounds would diminish wound contraction and scar formation. Microtextured wound covers, containing different concentrations of TGF-beta3, were placed onto full-thickness excisional skin wounds in guinea pigs. Tattooed reference marks were used to quantify wound contraction. Sixty-four male guinea pigs in four study groups (5 ng TGF-beta3, 50 ng TGF-beta3, no growth factor, sham wound) were followed for up to 6 weeks. We analyzed 19 different parameters of wound healing. Results showed that, in some instances, the 50-ng TGF-beta3 group gave less contraction, whereas the 5-ng TGF-beta3 group gave more contraction. These differences confirm that TGF-beta3 has an optimum working concentration, and suggest this concentration to be closer to 50 ng than to 5 ng TGF-beta3. However, only very few significant differences occurred, and thus we conclude that the clinical relevance of our findings is negligible. Earlier studies, reporting clinically improved wound healing by TGF-beta3, could therefore not be confirmed by this study.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Transforming growth factor‐β3–loaded microtextured membranes for skin regeneration in dermal wounds

Vooijs

Walboomers

Parker

et al. 2004

J Biomedical Materials Res

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“…There are a number of reasons that the guinea pig model is a preferred choice for radiation-induced skin injury studies. This rodent species has a skin architecture and thickness that is similar to humans (92), in that its hair growth cycle has follicles that grow independently in time (93), they are tight-skinned, and therefore have contracture similar to humans (94), and their metabolism and bacterial responses are also similar to humans (95). The company has used the Dunkin-Hartley guinea pig, an albino strain derived from the short-haired English guinea pig, as their animal model to assess MCMs for radiation skin injuries under the Animal Rule (K. Rodgers).…”

Section: Session 2: Radiation Sources and Animal Models Of Cutaneous mentioning

confidence: 99%

Cutaneous Radiation Injuries: Models, Assessment and Treatments

et al. 2020

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Many cases of human exposures to high-dose radiation have been documented, including individuals exposed during the detonation of atomic bombs in Hiroshima and Nagasaki, nuclear power plant disasters (e.g., Chernobyl), as well as industrial and medical accidents. For many of these exposures, injuries to the skin have been present and have played a significant role in the progression of the injuries and survivability from the radiation exposure. There are also instances of radiation-induced skin complications in routine clinical radiotherapy and radiation diagnostic imaging procedures. In response to the threat of a radiological or nuclear mass casualty incident, the U.S. Department of Health and Human Services tasked the National Institute of Allergy and Infectious Diseases (NIAID) with identifying and funding early-to mid-stage medical countermeasure (MCM) development to treat radiation-induced injuries, including those to the skin. To appropriately assess the severity of radiation-induced skin injuries and determine efficacy of different approaches to mitigate/treat them, it is necessary to develop animal models that appropriately simulate what is seen in humans who have been exposed. In addition, it is important to understand the techniques that are used in other clinical indications (e.g., thermal burns, diabetic ulcers, etc.) to accurately assess the extent of skin injury and progression of healing. For these reasons, the NIAID partnered with two other U.S. Government funding and regulatory agencies, the Biomedical Advanced Research and Development Authority (BARDA) and the Food and Drug Administration (FDA), to identify state-of-the-art methods in assessment of skin injuries, explore animal models to better understand radiation-induced cutaneous damage and investigate treatment approaches. A two-day workshop was convened in May 2019 highlighting talks from 28 subject matter experts across five scientific sessions. This report provides an overview of information that was presented and the subsequent guided discussions.

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