A “green” strategy to construct non-covalent, stable and bioactive coatings on porous MOF nanoparticles

Abstract

Nanoparticles made of metal-organic frameworks (nanoMOFs) attract a growing interest in gas storage, separation, catalysis, sensing and more recently, biomedicine. Achieving stable, versatile coatings on highly porous nanoMOFs without altering their ability to adsorb molecules of interest represents today a major challenge. Here we bring the proof of concept that the outer surface of porous nanoMOFs can be specifically functionalized in a rapid, biofriendly and non-covalent manner, leading to stable and versatile coatings. Cyclodextrin molecules bearing strong iron complexing groups (phosphates) were firmly anchored to the nanoMOFs' surface, within only a few minutes, simply by incubation with aqueous nanoMOF suspensions. The coating procedure did not affect the nanoMOF porosity, crystallinity, adsorption and release abilities. The stable cyclodextrin-based coating was further functionalized with: i) targeting moieties to increase the nanoMOF interaction with specific receptors and ii) poly(ethylene glycol) chains to escape the immune system. These results pave the way towards the design of surface-engineered nanoMOFs of interest for applications in the field of targeted drug delivery, catalysis, separation and sensing.

Chitosan-coated mesoporous MIL-100(Fe) nanoparticles as improved bio-compatible oral nanocarriers

“…In other words, an appropriate oral grafting is expected to be chemically robust in the desired physiological gastrointestinal media for a considerable time. The CS modification may therefore alter the specific oral chemical stability of MIL-100(Fe) NPs, as it has been already demonstrated with heparin coated NPs under simulated intravenous conditions14. The chemical stability of the CS coated NPs has been separately investigated through i) monitorization of the release of CS molecules by using a fluorescent-labelled CS and ii) the degradation profile of coated and non-coated NPs by quantifying the delivery of the organic linker (BTC).…”

Long‐Lived Room‐Temperature Phosphorescence of Coronene in Zeolitic Imidazolate Framework ZIF‐8

“…MOFs are crystalline materials composed of metal ions and organic ligands and are attracting considerable interest because of their thermal and chemical stability and ability to encapsulate a wide variety of guest species in their cavities, including gases, [12][13][14] nanoparticles, [15][16][17] enzymes, [18,19] and organic molecules. [20][21][22] The individual pores of MOFs can isolate guest emitters and restrict molecular motion by their rigid frameworks.…”

Anionic cyclodextrins as versatile hosts for pharmaceutical nanotechnology: Synthesis, drug delivery, enantioselectivity, contrast agents for MRI

“…Thus per-6-carboxylate and -sulfate anionic CDs are reported, since single-isomer per-6-phosphorylate CDs modified either in the primary or in the secondary sites have not been synthesized up to now (Agostoni et al, 2015;Grachev, 2013). The article additionally reviews self-assembly of anionic CDs, geometry of complexes, drug inclusion and release, as well as enantiomeric discrimination.…”