A green method for preparation of curcuminoid-rich Curcuma longa extract and evaluation of its anticancer activity

Lateh, Likit; Yuenyongsawad, Supreeya; Chen, Hạixia; Panichayupakaranant, Pharkphoom

doi:10.4103/pm.pm_162_19

Cited by 27 publications

(11 citation statements)

References 14 publications

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“…Extractions must be performed using nonpolar solvents since curcumin is not soluble in water. Previous investigations [40][41][42][43][44] have extracted the curcumin analogs using hexane, acetone, ethylene dichloride, and other alcohols.…”

Section: Effects Of Solvent Extraction Time Extraction and Purificati...mentioning

confidence: 99%

Extraction of Natural Food Color from Tomato, Carrot and Turmeric

Kabir,

Palleb,

Halim

et al. 2024

EJNFS

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The demand for natural and healthier food products has increased dramatically in recent years due to growing consumer awareness of the impact food has on health as well as evidence of adverse effects from various ingredients, including some additives. This study evaluates the extraction method, solvent effects, precipitation, identification, purification, and lycopene, carotene, and curcumin content from turmeric, carrot, and tomato. Along-side, tomato, carrot, and turmeric samples were subjected to two different extraction and purification processes: solvent extraction for lycopene and carotene, and alkalization for curcumin. The samples were extracted and purified at room temperature (30ºC) and chilled (4ºC) for a period of three weeks. Tomato extracts had lycopene contents ranging from 0.0153 to 0.0362 mg/100g. obtained carotene content, which was then extracted using a solvent in the range of 61.43 to 81.72 mg/100g. The alkalization process produced a curcumin concentration of 91.17 to 110.41 mg/100g. Comparing the ethyl acetate extraction technique to the anti-solvent method, a greater amount of lycopene (red) and carotene (orange) precipitation was obtained. The maximum amount of curcumin precipitation obtained in lower pH solution. Lower pH is important to maintain the stability of curcumin precipitation. The experience of this research work suggested that lycopene from tomatoes, carotene from carrots, and curcumin from turmeric might be an excellent source to meet the increasing need for natural colorants.

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Section: Effects Of Solvent Extraction Time Extraction and Purificati...mentioning

confidence: 99%

Extraction of Natural Food Color from Tomato, Carrot and Turmeric

Kabir,

Palleb,

Halim

et al. 2024

EJNFS

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“…CRE containing 88% w/w total curcuminoids (72.81% ± 0.83% w/w Cu, 12.49% ± w/w De, and 4.24% ± 0.16% w/w Bis; the curcuminoid content was measured by L al. using HPLC analysis [36]) and CRE-SD containing 7% w/w curcuminoids we pared using the method described by Lateh et al [36,37]. The dried powder of C rhizomes was dissolved in ethanol, and microwave-assisted extraction was per (900 W and three irradiation cycles; each cycle comprised 3 min on followed by 3 Then, the filtration and elution of the resulting C. longa extracts were conducted to CRE.…”

Section: Preparation Characterization and In Vitro Release Of Liposom...mentioning

confidence: 99%

Modified Curcuminoid-Rich Extract Liposomal CRE-SDInhibits Osteoclastogenesis via the Canonical NF-κB Signaling Pathway

Jantarawong,

Swangphon,

Lauterbach

et al. 2023

Pharmaceutics

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Curcuminoids, namely curcumin, demethoxycurcumin, and bisdemethoxycurcumin, are the major active compounds found in Curcuma longa L. (turmeric). Although their suppressive effects on bone resorption have been demonstrated, their pharmacokinetic disadvantages remain a concern. Herein, we utilized solid dispersion of a curcuminoid-rich extract (CRE), comprising such curcuminoids, to prepare CRE-SD; subsequently, we performed liposome encapsulation of the CRE-SD to yield liposomal CRE-SD. In vitro release assessment revealed that a lower cumulative mass percentage of CRE-SD was released from liposomal CRE-SD than from CRE-SD samples. After culture of murine RANKL-stimulated RAW 264.7 macrophages, our in vitro examinations confirmed that liposomal CRE-SD may impede osteoclastogenesis by suppressing p65 and IκBα phosphorylation, together with nuclear translocation and transcriptional activity of phosphorylated p65. Blind docking simulations showed the high binding affinity between curcuminoids and the IκBα/p50/p65 protein complex, along with many intermolecular interactions, which corroborated our in vitro findings. Therefore, liposomal CRE-SD can inhibit osteoclastogenesis via the canonical NF-κB signaling pathway, suggesting its pharmacological potential for treating bone diseases with excessive osteoclastogenesis.

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“…Briefly, 300 g plant powder into 500 mL of ethanol was heated in microwave for 3 cycles (900 W) at 70 o C (each cycle of 6 minutes with 1 minute pause between each cycle). The ethanol elution was subjected to rotary evaporation at 45 °C to get semisolid extract (Lateh at al., 2019).…”

Section: Microwave Assisted Extraction (Mae)mentioning

confidence: 99%

Neuroprotective evaluation of Marsilea quadrifolia L. and Salvinia molesta D.S Mitchel in aluminium chloride induced Alzheimer disease

MUSHTAQ,

HANIF,

SHAH

et al. 2023

Not Bot Horti Agrobo

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Phenolic compounds are very effective for the cure of various neurological and pathological diseases. Current study was conducted to estimate the Phenolic compounds through HPLC and to perform the anti-Alzheimer activity from two aquatic Leptosporangiate ferns; Marsilea quadrifolia L. and Salvinia molesta D. Crushed leaves were subjected to Microwave Assisted Extraction to prepare plant leave ethanolic extract of plants under study. Aluminum chloride induced Alzheimer’s disease model in rats by estimating behavioural and biochemical parameters were measured for ethanolic extract of both plants. Different behavioural tests were performed for neuromuscular coordination estimation and hole board test for exploratory behaviour were performed. The levels of AChE inhibitory activity and antioxidant enzymes were estimated on brain homogenates and Histopathological analysis were also performed. Phenolic compounds of leaf extracts were noted for HPLC chromatograms of standard compounds with Gallic acid (33.76 ± 0.08) higher in M. quadrifolia L. and Salicylic acid (12.45 ± 0.07) higher in S. molesta D. S Mitchel. Histopathological analysis showed that M. quadrifolia and S. molesta reversed the neurofibrillary tangles, degenerative changes, neuronal loss and neuroinflammation in the brain architecture. Both ferns at a dose of 500 mg/kg and 1000mg/kg significantly improved the Aluminium chloride induced neurotoxicity by modulating cognitive disabilities and motor dysfunctions, and normalized the biochemical alteration of acetylcholinesterase and antioxidant enzymes. In conclusion, both plants M. quadrifolia and S. molesta improved behavioural and biochemical parameters and therefore will be effective in treatment of neurodegenerative disorders via countless underlying mechanistic pathways.

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A green method for preparation of curcuminoid-rich Curcuma longa extract and evaluation of its anticancer activity

Cited by 27 publications

References 14 publications

Extraction of Natural Food Color from Tomato, Carrot and Turmeric

Extraction of Natural Food Color from Tomato, Carrot and Turmeric

Modified Curcuminoid-Rich Extract Liposomal CRE-SDInhibits Osteoclastogenesis via the Canonical NF-κB Signaling Pathway

Neuroprotective evaluation of Marsilea quadrifolia L. and Salvinia molesta D.S Mitchel in aluminium chloride induced Alzheimer disease

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