A green, efficient and stable platform based on hyperbranched quaternized hydrothermal magnetic chitosan nanospheres integrated cytomembranes for screening drug candidates from natural products

Sang, Zhenqi; Jiang, Zhixia; Liu, Sha; Ye, Pingyu; Hu, Sijing; Zhang, Qiaoyan; Zhu, Yan; Qin, Luping; Zhao, Qiming

doi:10.1016/j.ijbiomac.2023.129039

Cited by 2 publications

(1 citation statement)

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“…Unlike PEMFs, SMFs do not require a power device, making them more convenient and easier to use. Additionally, it is widely utilized in clinical settings due to its convenience and suitability for long-term use, without causing any harmful physical irritation to the surrounding tissues, such as heat or danger from electric shock 135 . Rare earth magnets that generate SMFs have been applied in various dental treatments, including magnetically fixed appliances for implants or tooth-retaining overdentures, maxillofacial prostheses after trauma and cancer surgery, and orthodontic procedures such as gap closure, molar distal intrusion, tooth traction, and palatal expansion 136 .…”

Section: Biophysical Stimulation For Osteoporotic Osseointegration An...mentioning

confidence: 99%

Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies

Chen,

Hao,

et al. 2024

Theranostics

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Osteoporosis is a systemic skeletal disease caused by an imbalance between bone resorption and formation. Current treatments primarily involve systemic medication and hormone therapy. However, these systemic treatments lack directionality and are often ineffective for locally severe osteoporosis, with the potential for complex adverse reactions. Consequently, treatment strategies using bioactive materials or external interventions have emerged as the most promising approaches. This review proposes twelve microenvironmental treatment targets for osteoporosis-related pathological changes, including local accumulation of inflammatory factors and reactive oxygen species (ROS), imbalance of mitochondrial dynamics, insulin resistance, disruption of bone cell autophagy, imbalance of bone cell apoptosis, changes in neural secretions, aging of bone cells, increased local bone tissue vascular destruction, and decreased regeneration. Additionally, this review examines the current research status of effective or potential biophysical and biochemical stimuli based on these microenvironmental treatment targets and summarizes the advantages and optimal parameters of different bioengineering stimuli to support preclinical and clinical research on osteoporosis treatment and bone regeneration. Finally, the review addresses ongoing challenges and future research prospects.

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Section: Biophysical Stimulation For Osteoporotic Osseointegration An...mentioning

confidence: 99%