A Green Approach to Synthesize Dihydropyrimidinone Derivatives by Using Anhydrous ZnCl2 Catalyst Under Refluxing Condition in Heptane-Toluene Medium via Biginelli Reaction

Akhter, Khaleda; Jahan, Khurshid; Romman, Ukr; Ahmed, Manzur; Rahman, Md. Sharifur; Al-Amin, Md.

doi:10.14233/ajchem.2015.18615

Cited by 6 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, a facile efficient process is still desirable. As a continuation our research goal to develop a convenient method to synthesize valuable synthon [33][34][35][36] from easily available starting materials, we developed a two-step method to synthesize thiazolidine-2,4-dione derivatives by using morpholine as a catalyst. We have performed Density functional theory (DFT) calculations in all our synthesized molecules to find out most active compound.…”

Section: Introductionmentioning

confidence: 99%

A convenient approach to synthesize substituted 5-Arylidene-3-m-tolyl thiazolidine-2, 4-diones by using morpholine as a catalyst and its theoretical study

et al. 2021

Self Cite

View full text Add to dashboard Cite

Thiazolidinediones are very important and used as a drug for the treatment of type 2 diabetes. Here, we report a convenient approach to synthesis 3-m-tolyl-5-arylidene-2,4-thiazolidinediones (TZDs) derivatives 7a-e in two steps with moderate to good yield using morpholine as a catalyst. All the structures were confirmed by their spectral IR, 1H NMR and 13C NMR data. The anti-diabatic activity of all synthesized molecules is evaluated by docking with peroxisome proliferator-activated receptor-γ (PPARγ). Preliminary flexible docking studies reveals that our compounds 7a, 7d and 7e showed better binding affinity with the protein and could be a potential candidate for the treatment of type 2 diabetes in near future.

show abstract

Section: Introductionmentioning

confidence: 99%

A convenient approach to synthesize substituted 5-Arylidene-3-m-tolyl thiazolidine-2, 4-diones by using morpholine as a catalyst and its theoretical study

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…In continuation of our interest in the synthesis of fused pyrimidines (Akhter et al, 2015), we report herein a simple, efficient procedure for one-pot synthesis of 3,4 -dihydropyrimidin-2(1H)-thiones derivatives 4a-f using Ni(NO 3 ) 2 .6H 2 O as a catalyst under solvent free conditions through Biginelli reactions (Scheme 1). The synthesized compounds were evaluated for in vitro antimicrobial activity against Staphylococcus aureus, Bacillus cereus (gram +ve), Escherichia coli, Salmonella typhimerium (gram-ve) using KIRBY-BAUER method (Bauer et al, 1966).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 1-phenyl-3, 4-dihydropyrimidine-2(1H)-ones derivatives under solvent free condition and their antimicrobial activity

Akhter

Jahan

Halim

et al. 2019

Bangladesh J. Sci. Ind. Res.

View full text Add to dashboard Cite

We report herein the use of nickel nitrate hexahydrate [Ni(NO3)2.6H2O] as a new catalyst for the one-pot Biginelli like reaction coupling of 1-phenyl thiourea, ethyl acetoacetate and aromatic aldehydes to afford the corresponding 1-phenyl-3,4-dihydropyrimidin-2(1H)-thiones under solvent free condition to avoid the usage of hazardous organic solvents. The synthesized compounds were evaluated for their antimicrobial activity by KIRBY-BAUER disk diffusion method. Most of the compounds showed good to moderate antimicrobial activity. Bangladesh J. Sci. Ind. Res.54(1), 47-54, 2019

show abstract

Punica granatum peel: an organocatalyst for green and rapid synthesis of 3,4-dihydropyrimidin-2 (1H)-ones/thiones under solvent-free condition

Mohammadian

Akhlaghinia

2016

Res Chem Intermed

View full text Add to dashboard Cite

A Green Approach to Synthesize Dihydropyrimidinone Derivatives by Using Anhydrous ZnCl2 Catalyst Under Refluxing Condition in Heptane-Toluene Medium via Biginelli Reaction

Cited by 6 publications

References 0 publications

A convenient approach to synthesize substituted 5-Arylidene-3-m-tolyl thiazolidine-2, 4-diones by using morpholine as a catalyst and its theoretical study

A convenient approach to synthesize substituted 5-Arylidene-3-m-tolyl thiazolidine-2, 4-diones by using morpholine as a catalyst and its theoretical study

Synthesis of 1-phenyl-3, 4-dihydropyrimidine-2(1H)-ones derivatives under solvent free condition and their antimicrobial activity

Punica granatum peel: an organocatalyst for green and rapid synthesis of 3,4-dihydropyrimidin-2 (1H)-ones/thiones under solvent-free condition

Contact Info

Product

Resources

About