A gold nanoparticle-modified indium tin oxide microelectrode for in-channel amperometric detection in dual-channel microchip electrophoresis

Zhu, Gangzhi; Song, Qianhui; Liu, Wenfang; Yan, Xing-Xing; Xiao, Jian; Chen, Chuanpin

doi:10.1039/c7ay01008g

Cited by 21 publications

(13 citation statements)

References 60 publications

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“…In addition, there is one paper dealing about gold nanoparticle‐based ED . In this paper, a modified indium tin oxide microelectrode integrated with a dual‐channel PDMS microchip (in‐channel configuration) was fabricated via a photolithography process.…”

Section: Ed Based On Nanomaterials In Capillary and Microchip Electromentioning

confidence: 99%

Electrochemical detection based on nanomaterials in CE and microfluidic systems

2018

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Electrochemical detection has a great potential in microfluidic systems due to its easy miniaturization without losing analytical performance. In addition, the use of nanomaterials in electroanalysis improves sensitivity, selectivity, and reproducibility. The topic of this review is the use of nanomaterials (nanoparticles, nanotubes, graphene) in electrochemical detection for capillary electrophoresis and microfluidic systems (microchips and paper based analytical devices). This review covers from 2015 up to now and it is a continuation of our previous review, also published in Electrophoresis journal. The following aspects of the surveyed articles are mainly addressed: type of nanomaterial, protocol of working electrode preparation (composite, drop casting and others), advantages of nanomaterial employment and application field (clinical, food, environmental and home security). The use of nanomaterials is still an interesting approach to improve the analytical performance of electrochemical detection based on microfluidic devices. Along the review, readers will find new protocols for working electrode modification, new carbon nanomaterials and promising applications in the aforementioned fields.

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Section: Ed Based On Nanomaterials In Capillary and Microchip Electromentioning

confidence: 99%

Electrochemical detection based on nanomaterials in CE and microfluidic systems

2018

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“…The SPR-based CFP-10 antigen detection system was developed in clinical samples by Yang et al (2014), which showed reputable usefulness in TB diagnostics (Hsieh et al 2012;Yang et al 2014). Zhu et al (2017) developed AuNPs modified indium tin oxide (ITO) electrode for the direct detection of M. tuberculosis using genomic DNA (gDNA) isolated directly from clinical samples. The method utilized two probes: capture probe and gold nanoprobe coupled with alkaline phosphatase (ALP) enzyme as detection probe.…”

Section: Gold Nanoparticle (Aunps)-based Diagnostics For Tbmentioning

confidence: 99%

“…Finally, ITO is placed as electrode in the buffer containing detection probe to generate hybridization sandwich. The electric signals are then recorded using voltametry (Zhu et al 2017).…”

Section: Gold Nanoparticle (Aunps)-based Diagnostics For Tbmentioning

confidence: 99%

Diagnosis of Tuberculosis: Nanodiagnostics Approaches

Gupta

Singh

2020

NanoBioMedicine

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Tuberculosis (TB) remains one of the most devastating infectious diseases worldwide. The burden of TB is alarmingly high in developing countries, where diagnosis latent TB infection (LTBI), Extra-pulmonary tuberculosis (EPTB), drug-resistant tuberculosis (DR-TB), HIV-associated TB, and paediatric TB is still a challenge. This is mainly due to delayed or misdiagnosis of TB, which continues to fuel its worldwide epidemic. The ideal diagnostic test is still unavailable, and conventional methods remain a necessity for TB diagnosis, though with poor diagnostic ability. The nanoparticles have shown potential for the improvement of drug delivery, reducing treatment frequency and diagnosis of various diseases. The engineering of antigens/antibody nanocarriers represents an exciting front in the field of diagnostics, potentially flagging the way toward development of better diagnostics for TB. This chapter discusses the presently available tests for TB diagnostics and also highlights the recent advancement in the nanotechnology-based detection tests for M. tuberculosis.

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“…Bacterial infections were identified on a paper-based MCE device [135] and bacterial resistance was investigated using DEP and Raman spectroscopy [136]. Furthermore, MCE with electrochemical detection was applied for the determination of antibiotic drugs in biological samples [137,138]. For instance, the antibiotic formulation sulperazone was determined using a novel gold nanoparticle-modified indium tin oxide microelectrode for amperometric detection [137].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Furthermore, MCE with electrochemical detection was applied for the determination of antibiotic drugs in biological samples [137,138]. For instance, the antibiotic formulation sulperazone was determined using a novel gold nanoparticle-modified indium tin oxide microelectrode for amperometric detection [137].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

A decade of microchip electrophoresis for clinical diagnostics – A review of 2008–2017

Wuethrich

Quirino

2019

Analytica Chimica Acta

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A core element in clinical diagnostics is the data interpretation obtained through the analysis of patient samples. To obtain relevant and reliable information, a methodological approach of sample preparation, separation, and detection is required. Traditionally, these steps are performed independently and stepwise. Microchip capillary electrophoresis (MCE) can provide rapid and high-resolution separation with the capability to integrate a streamlined and complete diagnostic workflow suitable for the point-of-care setting. Whilst standard clinical diagnostics methods normally require hours to days to retrieve specific patient data, MCE can reduce the time to minutes, hastening the delivery of treatment options for the patients. This review covers the advances in MCE for disease detection from 2008 to 2017. Miniaturised diagnostic approaches that required an electrophoretic separation step prior to the detection of the biological samples are reviewed. In the two main sections, the discussion is focused on the technical setup used to suit MCE for disease detection and on the strategies that have been applied to study various diseases. Throughout these discussions MCE is compared to other techniques to create context of the potential and challenges of MCE. A comprehensive table categorised based on the studied disease using MCE is provided. We also comment on future challenges that remain to be addressed.

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A gold nanoparticle-modified indium tin oxide microelectrode for in-channel amperometric detection in dual-channel microchip electrophoresis

Abstract: A modified indium tin oxide (ITO) microelectrode detector integrated with a dual-channel polydimethylsiloxane (PDMS) microchip is proposed for in-channel amperometric detection in microchip electrophoresis (ME).

Cited by 21 publications

References 60 publications

Electrochemical detection based on nanomaterials in CE and microfluidic systems

Electrochemical detection based on nanomaterials in CE and microfluidic systems

Diagnosis of Tuberculosis: Nanodiagnostics Approaches

A decade of microchip electrophoresis for clinical diagnostics – A review of 2008–2017

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