A Gluten-Free Diet as an Intervention for Autism and Associated Spectrum Disorders: Preliminary Findings

Whiteley, Paul; Rodgers, Jacqui; Savery, Dawn; Shattock, Paul

doi:10.1177/1362361399003001005

Cited by 117 publications

(95 citation statements)

References 13 publications

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“…[11] analizowali skutki interwencji dietetycznej u 188 chorych w 14 ba daniach, z których tylko w jednym stosowano wy łącznie dietę bezglutenową [12], a w pozostałych w połą czeniu z bezkazeinową i róż-nymi suplementami. W 7 ba daniach, w tym gdzie jedyną interwencją była eliminacja glutenu [12], stwierdzono pozytywny efekt diety, jednak w żadnym z nich nie było grupy porównawczej umożliwiającej wykluczenie skutków naturalnego dojrzewania pacjentów i równoczesnej terapii behawioralnej. Od kilku lat oczekiwane są wyniki dwóch badań interwencyjnych z randomizacją, zgłoszo-nych do Clinical Trial Registry, tj.…”

Section: Skuteczność Diety Bezglutenowej W Leczeniu Chorób Z Zakresu unclassified

“…Spożywanie posiłków poza domemnajważniejsze wskazówki i pokarmy często nieidentyfikowane przez konsumentów i gastronomię jako zawierające gluten Table IV. Eating out -most important recommendations and frequently overlooked foods that often contain gluten istycznymi opisami przypadków zwiększa się liczba badań naukowych dokumentujących, nie tylko incydentalnie, korzystny wpływ diety bezglutenowej na przebieg tego schorzenia [12]. W świetle aktualnych systematycznych przeglądów piśmiennictwa [7,10,11] wdrożenie diety bezglutenowej u większości chorych, z wyjątkiem tych ze stwierdzonymi nietolerancjami pokarmowymi i celiakią, jest jednak wyborem zdesperowanego rodzica lub opiekuna, a nie sięgnięciem po terapię oferowaną przez medycynę opartą na faktach.…”

Section: Wnioskiunclassified

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Gluten-free diet in the treatment of autism spectrum disorders – a short overview

Hozyasz¹,

Gryglicka²,

Żółkowska³

2010

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Słowa kluczowe: dieta bezglutenowa, autyzm, nietolerancja pokarmowa. Key words: gluten-free diet, autism, food intolerance.Adres do korespondencji: dr n. med. Kamil K. Hozyasz, Klinika Pediatrii, Instytut Matki i Dziecka, ul. Kasprzaka 17a, 01-211 Warszawa, tel. +48 22 327 72 68, e-mail: kamil.hozyasz@imid.med.pl Artykuł poglądowy/Review paper StreszczeniePo poradę dotyczącą diety bezglutenowej zgłaszają się zazwyczaj chorzy z zaburzeniami ze spektrum autyzmu (autistic spectrum disorders -ASD), należący do dwóch grup. Większość stanowią młodsze dzieci z ASD i ich rodzice. Nieliczną grupą są wcześniej niezdiagnozowani nastolatkowie i młodzi dorośli z łagodnymi postaciami ASD, którzy wskutek własnych poszukiwań stwierdzili, że ich sprawność społeczna i kreatywność zwiększyła się po eliminacji glutenu z diety. Relacjonują oni bardzo dużą wrażliwość na niezamierzone błędy dietetyczne. W artykule przedstawiono zagadnienie stosowania diety bezglutenowej w ASD na podstawie najnowszych przeglądów piśmiennictwa oraz badań oryginalnych. Wyniki wieloletnich obserwacji pokazują, że u części osób z ASD eliminacja glutenu z diety może korzystnie wpły-wać na zaburzenia psychiczne. Bardzo zmienny wzorzec snu, częste ostre zmiany zachowania i epizody zwiększonej agresji, objawy nietolerancji pokarmów oraz pozytywne wyniki badań laboratoryjnych w kierunku alergii pokarmowej są wskazywane jako pomocne w identyfikacji chorych odnoszących korzyść z wprowadzenia diety bezglutenowej. Niezbędne są dalsze, prawidłowo zaplanowane badania w celu udokumentowania korzyści ze stosowania diety bezglutenowej u pacjentów z różnymi zaburzeniami ze spektrum autyzmu. AbstractThere are two groups of patients with autistic spectrum disorders (ASD) referred to clinicians for information about intervention with a gluten-free diet. The ASD children and their parents are the majority. Previously undiagnosed teenagers and young adults, who fulfil the criteria of a mild ASD and have experienced improvement in social interaction and general well-being after a self-administered gluten-free diet, are the small minority. We observed only a small number of patients (6 males) from the last group, who looked for explanation and laboratory confirmation of their gluten intolerance. They reported to be very sensitive to unintentional gluten consumption. This article provides a summary of current systematic reviews and original papers on the effects of a gluten-free diet in the treatment of ASD. Accumulating evidence suggests that in a portion of patients gluten may contribute significantly to autistic behaviour and should be eliminated from the diet. Irregular sleeping pattern, episodes of aggression and acute behavioural changes, biological food intolerance, and positive results of laboratory tests for food allergies are considered to be helpful in identifying responders to a gluten-free diet among children with ASD. Future investigations should use validated and reliable outcome measures to determine the benefits of a gluten-free diet in patients with different t...

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Section: Skuteczność Diety Bezglutenowej W Leczeniu Chorób Z Zakresu unclassified

Section: Wnioskiunclassified

Gluten-free diet in the treatment of autism spectrum disorders – a short overview

Hozyasz¹,

Gryglicka²,

Żółkowska³

2010

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“…As principais condições adversas ao glúten que podem vir a ocorrer com o indivíduo saudável, necessitando, portanto de restrição são: a doença celíaca, caracterizada pela intolerância permanente as proteínas do glúten; a alergia ao glúten, a qual é mediada pela imunoglobulina E (IgE); a sensibilidade ao glúten, que é de mais difícil diagnóstico; a ataxia por glúten, marcada por manifestações neurológicas relacionadas à ingestão de glúten; e o controle do Espectro Autista mediante a regulação de ingestão de glúten (WHITELEY et al, 1999). Na presença desta intolerância, os alimentos que contêm glúten devem ser substituídos por outros, como por exemplo: milho, arroz, soja, batata e mandioca, de forma que a dieta atenda às necessidades nutricionais do indivíduo (FARO, 2008;LA BARCA et al, 2010).…”

Section: Introductionunclassified

Desenvolvimento De Chocolate Recheado Sem Lactose E Sem Glúten

Sommer

Wollmuth

Alexandre

et al. 2017

Destaques Acadêmicos

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Resumo: A intolerância ao glúten e a lactose são caracterizadas como uma alergia ou sensibilidade que geram condições adversas no sistema digestório, metabólico ou neural de um indivíduo. Tratando-se de uma alergia, o indivíduo tem por restrição a ingestão de proteínas específicas, cujo efeito principal é um ataque ao sistema imunológico, podendo causar diversas reações agressivas, inclusive ataques anafiláticos. Quando tratado como sensibilidade, o sistema imunitário gera condições semelhantes a uma alergia, onde faz-se necessário a substituição parcial ou total na ingestão de determinados alimentos, visando evitar respostas anormais do corpo humano. Seguindo esta linha de estudo, objetivou-se produzir um chocolate benéfico à saúde, livre de lactose e glúten, a fim de proporcionar mais sabor a dietas restritivas. As formulações foram elaboradas com recheio de amendoim, que é fonte de diversos aminoácidos, minerais e vitaminas e grande aliado nas dietas, pois é fonte de ácidos graxos essenciais para a saúde. Durante o desenvolvimento do produto, foram produzidas três formulações de recheio, utilizando leite condensado, outro usando pasta de amendoim e o terceiro uma mistura dos dois componentes, e para todas as formulações o chocolate meio amargo. Para garantia de

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“…The GFCF diet is an elimination diet, which implies that certain food proteins, like gluten and casein, need to be eliminated from the usual diet and many studies investigated the effects of this dietary intervention on ASD symptoms [48][49][50][51][52][53][54][55][56][57][58][59]. In the GFCF diet, processed carbohydrates containing gluten are replaced with gluten-free processed carbohydrates generally obtained from rice, sugar, potato starch, tapioca flour, soy, buckwheat flour, etc.…”

Section: Gluten and Casein Proteins Affect The Brain Via The Bloodstreammentioning

confidence: 99%

Untitled

2015

HCIIN

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There is a rising interest in the use of dietary interventions to ameliorate prevalent brain diseases, including Autism Spectrum Disorder (ASD). Nowadays, the existence of communication between gut and brain is well accepted and thus diet can influence brain functioning. A well-known nutrition based intervention for ASD is the gluten-free and casein-free diet. However, only some of the patients experience a relief in symptoms and thus efficacy seems to be limited to certain phenotypes. However, not much is known about the mechanism of action through which this diet might work, or about interpersonal differences that could lead to variation in response to the diet. Current evidence for efficacy of the GFCF diet is poor. Large scale, good quality randomized controlled trials are needed. Genetic and environmentally induced interpersonal differences were found in intestinal membrane permeability and blood brain barrier integrity as well as in activity of peptidase enzymes. These differences probably affect responsiveness to the diet. In addition, age and duration of the dietary intervention play a role in the efficacy of the gluten-free and casein-free diet. This is the reason why all these factors need to be taken into account to give appropriate advice about whether or not to follow this diet.Keywords: Autism spectrum disorder; Casein-free; Casomorphin; Diet; Gluten-free; Intervention; Opioid; Peptides; Permeability Treating Autism Spectrum Disorder with Gluten-free and Casein-free Diet: The underlying Microbiota-Gut-Brain Axis MechanismsCitation: Cieślińska A, Kostyra E, Savelkoul HFJ (2017) Treating Autism Spectrum Disorder with • (GFCF) diet is strongly promoted while there are additional diets without salicylates and phenols, and anti-candida diets since many ASD patients are affected by this yeast [17]. However, so far it has been difficult to prove the effectiveness of this diet in all patients [10,18]. Limited information is available on the underlying mechanism as well as explanatory factors of differences in response to the GFCF diet. Here, we focus on the mechanism of action underlying this dietary intervention as well as the origin of differences in response to the GFCF diet. Gluten-Free and Casein-Free Diet Might Alleviate Autism Spectrum Disorder SymptomsPeople with ASD are often in need of intensive care and guidance, leading to loss of parental productivity and high emotional and economic costs [8,19]. Therefore it is important to investigate potential treatments that alleviate the symptoms or preferably cure the disease. So far, sometimes life long, educational and behavioral interventions are used, although these therapies have limited efficacy for ASD [6,20]. Currently, there is growing interest in nutritional interventions for this disorder and there are promising mechanisms underlying the putative success of such interventions [19].In 1983 it was suggested that gluten and casein containing products could cause autism-like symptoms by altering the functioning of the brain. It was propo...

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A Gluten-Free Diet as an Intervention for Autism and Associated Spectrum Disorders: Preliminary Findings

Cited by 117 publications

References 13 publications

Gluten-free diet in the treatment of autism spectrum disorders – a short overview

Gluten-free diet in the treatment of autism spectrum disorders – a short overview

Desenvolvimento De Chocolate Recheado Sem Lactose E Sem Glúten

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