A glucose biosensor based on modified-enzyme incorporated within electropolymerised poly(3,4-ethylenedioxythiophene) (PEDT) films

Piro, Benoı̂t; Dang, Lan Anh; Pham, Minh; Fabiano, Silvia; Tran‐Minh, Canh

doi:10.1016/s0022-0728(01)00595-2

Cited by 81 publications

(44 citation statements)

References 39 publications

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“…Their bimolecular rate constants for FADH 2 -GOx oxidation range from 3 × 10 4 to 8 × 10 6 M -1 s -1 . 148 The most intensively studied ferrocene-derivatives are ferrocenemethanol 88,90,91,[149][150][151][152][153][154][155][156][157][158][159][160][161] and ferrocenecarboxylic acid. 155,[162][163][164] Several of the ferrocenes meet the requirements for application in blood-glucose analyzers, which include high solubility in water, fast electron-shuttling, stability, and pH-independence of the redox potential.…”

Section: Metal-organic Mediatorsmentioning

confidence: 99%

Electrochemical Glucose Sensors and Their Applications in Diabetes Management

2008

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About 6,000 peer reviewed articles have been published on electrochemical glucose assays and sensors, of which 700 were published in the 2005-2006 two-year period. Their number makes a full review of the literature, or even of the most recent advances, impossible. Nevertheless, this review should acquaint the reader with the fundamentals of the electrochemistry of glucose and provide a perspective of the evolution of the electrochemical glucose assays and monitors helping diabetic people, who constitute about 5% of the world's population. Because of the large number of diabetic people, no assay is performed more frequently than that of glucose. Most of these assays are electrochemical. The reader interested also in nonelectrochemical assays used in, or proposed for, the management of diabetes is referred to a 2007 review of Kondepati and Heise. 1 Adam Heller was born in 1933. Surviving the Holocaust, he arrived in Israel in 1945. He received his M.Sc. in Chemistry and Physics in 1957, then his PhD in Organic Chemistry in 1961 from Ernst David Bergman at the Hebrew University in Jerusalem. He postdoced at UC Berkeley (1962-3) and at Bell Laboratories . At GTE Labs (1964-1975 he built the first Nd 3+ liquid laser and, with J. J. Auborn, the still worldwide used Li/SOCl 2 battery. At Bell Labs (1975)(1976)(1977)(1978)(1979)(1980)(1981)(1982)(1983)(1984)(1985)(1986)(1987)(1988) he designed the first >10% efficient electrochemical solar cells and the first >10% efficient hydrogengenerating solar-powered photoelectrode. He also headed Bell Labs' Electronic Materials Research Department (1977)(1978)(1979)(1980)(1981)(1982)(1983)(1984)(1985)(1986)(1987)(1988), which developed part of the high density chip interconnection technology underlying the miniaturization of portable electronic devices. He was appointed to the Ernest Cockrell Sr. Chair in Engineering of the University of Texas at Austin in 1988, and in 2001 became one of UT's first Research Professors. At UT he pioneered the electrical wiring of enzymes. In 1996 he cofounded with his son Ephraim Heller TheraSense Inc., now part of Abbott Diabetes Care, to improve the lives of diabetic people. The company introduced in 2000 the blood sugar monitor FreeStyle, a thin-layer microcoulometer utilizing only 300 nL of blood, so little that it was, for the first time, painlessly obtained. In 2007 it provided for more than 1 billion painless glucose assays. After alleviating the pain of diabetes monitoring, FreeStyle Navigator, based on the electrical wiring of glucose oxidase, introduced in 2007 in Europe and Israel and in 2008 in the U.S., removed the worry of diabetic people by continuously monitoring their glucose levels. Heller aims his work at alleviating suffering through bioelectrochemistry.

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Section: Metal-organic Mediatorsmentioning

confidence: 99%

Electrochemical Glucose Sensors and Their Applications in Diabetes Management

2008

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“…The enhancement of the performance characteristics of sensors and biosensors, based on carbon electrode substrates, can be achieved through different surface modification strategies such as the deposition of films of polymeric redox mediators [17], application of nanotubes or the immobilisation of enzymes into polymer matrices [18,19]. Ensuring sensor selectivity towards a given compound is a constant challenge and hydrogen peroxide (H 2 O 2 ), selected in this work, is a compound with important applications in environmental studies, chemical industry, pharmaceutical and industrial research [20,21].…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterisation of poly(3,4-ethylenedioxythiophene) and poly(3,4-ethylenedioxythiophene)/poly(neutral red) modified carbon film electrodes, and application as sensors for hydrogen peroxide

Gonçalves

Ghica

Brett

2011

Electrochimica Acta

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Please cite this article as: A.R. Gonçalves, M.E. Ghica, C.M.A. Brett, Preparation and characterisation of poly (3,4-ethylenedioxythiophene) and poly(3,4-ethylenedioxythiophene)/poly(neutral red) modified carbon film electrodes; and application as sensors for hydrogen peroxide, Electrochimica Acta (2010Acta ( ), doi:10.1016Acta ( /j.electacta.2010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. carbon-film electrodes (CFE) in aqueous solution using electropolymerisation by potential cycling, potentiostatically and galavanostatically. Characterisation of the modified electrodes was done by cyclic voltammetry and electrochemical impedance spectroscopy and the stability of the polymer films was probed. The coated electrodes were tested for application as hydrogen peroxide sensors, by oxidation and reduction. A novel polymer film was also formed by modification of CFE by co-electropolymerisation of EDOT and the phenazine dye neutral red (NR) -(PEDOT/PNR) with a view to enhancing the properties for sensor applications. It was found that hydrogen peroxide reduction at the PEDOT/PNR coated electrodes could be carried out at a less negative potential, the sensor performance comparing very favourably with that of other polymer-modified electrodes reported in the literature.

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“…The sensitivity calculated from the calibration curve was 20.5 μA cm -2 mM -1 , which is an about 38-fold augmentation over the HRP-based, thermal inkjet printed glucose sensor (0.54 μA cm -2 mM -1 ). 2 The higher sensitivity, compared to the glucose sensors fabricated by other methods, 1,[27][28][29] may be attributed to the combination of the advantageous features of bienzymatic sensing and conducting polymers with piezoelectric inkjet printing. Bienzymatic glucose sensing systems have shown much higher sensitivity when compared to monoenzymatic ones.…”

Section: [Fcmeoh]mentioning

confidence: 99%