A global representation of vitamin D status in healthy populations

Wahl, D. A.; Cooper, Cyrus; Ebeling, Peter R.; Eggersdorfer, Manfred; Hilger, Jennifer; Hoffmann, Kristina; Josse, Robert G.; Kanis, John А.; Mithal, Ambrish; Pierroz, Dominique D.; Stenmark, J; Stöcklin, Elisabeth; Dawson‐Hughes, Bess

doi:10.1007/s11657-012-0093-0

Cited by 271 publications

(212 citation statements)

References 208 publications

Supporting

Mentioning

192

Contrasting

Unclassified

Order By: Relevance

“…We found that CCM patients with one or more features of the more aggressive chronic clinical course had lower 25-(OH) vitamin D and non-HDL cholesterol values. The ROC curve generated threshold of 25.68 ng/ml for vitamin D found in the chronic aggressive group, represents a suboptimal value according to published consensus statement [29] and systematic reviews [20,30] designating 30 ng/ml as the value below which vitamin D is insufficient. This shows that CCM subjects with chronic disease aggressiveness not only have lower vitamin D levels compared with those with nonaggressive disease, but are actually deficient compared with the general population.…”

Section: Rock Activity In Leukocytes and Plasma Crp Activity Are Not Comentioning

confidence: 99%

Peripheral Plasma Vitamin D and Non-HDL Cholesterol Reflect the Severity of Cerebral Cavernous Malformation Disease

et al. 2016

View full text Add to dashboard Cite

Aim: To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically. Patients & methods: A prospective case–control study enrolled 43 CCM patients, where 25-(OH) vitamin D, HDL and non-HDL cholesterol, CRP plasma levels and leukocyte ROCK activity were correlated with parameters of disease aggressiveness reflecting chronic and acute domains. Results: Patients with one or more features of chronically aggressive disease (early age at symptom onset, two or more symptomatic bleeds, high lesion burden) had significantly lower 25-(OH) vitamin D and non-HDL cholesterol levels in comparison to patients without these features. Conclusion: Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease.

show abstract

Section: Rock Activity In Leukocytes and Plasma Crp Activity Are Not Comentioning

confidence: 99%

Peripheral Plasma Vitamin D and Non-HDL Cholesterol Reflect the Severity of Cerebral Cavernous Malformation Disease

et al. 2016

View full text Add to dashboard Cite

show abstract

“…An extensive array of studies including a mix of both representative and convenience sampling frames have reported 25(OH)D concentrations among older adults all over the globe (8,(26)(27)(28) . Without doubt, the region with the most available data on 25(OH)D concentrations is Europe, followed by North America and Asia.…”

Section: Circulating 25(oh)d Concentrations In Older Agementioning

confidence: 99%

Vitamin D and bone health outcomes in older age

2013

View full text Add to dashboard Cite

The aim of this review is to summarise the evidence linking vitamin D to bone health outcomes in older adults. A plethora of scientific evidence globally suggests that large proportions of people have vitamin D deficiency and are not meeting recommended intakes. Older adults are at particular risk of the consequences of vitamin D deficiency owing to a combination of physiological and behavioural factors. Epidemiological studies show that low vitamin D status is associated with a variety of negative skeletal consequences in older adults including osteomalacia, reduced bone mineral density, impaired Ca absorption and secondary hyperparathyroidism. There seems to be inconsistent evidence for a protective role of vitamin D supplementation alone on bone mass. However, it is generally accepted that vitamin D (17 . 5 mg/ d) in combination with Ca (1200 mg/d) reduces bone loss among older white subjects. Evidence for a benefit of vitamin D supplementation alone on reducing fracture risk is varied. According to a recent Agency for Healthcare Research and Quality review in the USA the evidence base shows mixed results for a beneficial effect of vitamin D on decreasing overall fracture risk. Limitations such as poor compliance with treatment, incomplete assessment of vitamin D status and large drop-out rates however, have been highlighted within some studies. In conclusion, it is generally accepted that vitamin D in combination with Ca reduces the risk of non-vertebral fractures particularly those in institutional care. The lack of data on vitamin D and bone health outcomes in certain population groups such as diverse racial groups warrants attention. 25-hydroxyvitamin D: Vitamin D requirements: Older age: Bone mineral density: FracturesOsteoporosis is a condition characterised by a low bone mass and microarchitectural deterioration of bone with a consequent increase in bone fragility and susceptibility to fracture. In the UK, it is estimated that 3 million people are affected with osteoporosis. Furthermore, one in two British women and one in five British men aged > 50 years will experience an osteoporotic fracture in their lifetime with the estimated costs in the UK being about £1 . 7 billion annually. In the European Union, it has been estimated that previous and incident fractures accounted for 1 180 000 quality-adjusted life years lost during 2010 (1) . Furthermore, with an ageing population, the costs associated with treating osteoporosis in the EU are expected to increase by 25% in 2025(1) . Bone is a dynamic tissue that responds to the external and internal environments to which it is exposed during an individual's lifetime. While a considerable proportion (up to 70%) of the inter-individual variation in bone mass is genetically determined, lifestyle factors such as diet and exercise are well established modifiable factors of bone mass. Bone turnover is important for the self-repair of skeletal tissue (2) as well as maintaining mineral homoeostasis (e.g. Ca and P) and the balance between the rate of bone formation ...

show abstract

“…Low levels of vitamin D are reported in diverse populations around the world (1)(2)(3) , with one review suggesting that as many as 14 % of the world's population have levels inadequate for general well-being (4) . Serum concentration of 25-hydroxyvitamin D (s-25(OH)D) is the standard assessment for vitamin D status in the body and s-25(OH)D concentration of 50 nmol/l or more is considered sufficient for optimal bone-related health outcomes by the Institute of Medicine (5) .…”

mentioning

confidence: 99%

Vitamin D status in pre-school children in rural Nepal

Avagyan

Gundersen²,

Madar³

2015

Public Health Nutr.

View full text Add to dashboard Cite

Objective: Vitamin D plays a major role in Ca and bone metabolism, and its extraskeletal functions are being appraised. Although inadequate vitamin D concentrations have been reported in populations worldwide, too little is known about vitamin D status and its determinants among children in developing countries. We aimed to determine vitamin D status and its determinants in Nepalese children of pre-school age. Design: A community-based, cross-sectional study. Setting: Rural Nepal at latitude 27·39°N. Subjects: Healthy children (n 280) aged 12-60 months, selected randomly from the records of a vitamin A supplementation programme. Blood samples were collected using the dried blood spot technique and analysed for serum 25-hydroxyvitamin D (s-25(OH)D) concentration using liquid chromatographytandem mass spectrometry. Ca intake and background variables were assessed with a structured questionnaire. Results: Hypovitaminosis D, defined as s-25(OH)D concentration less than 50 nmol/l, was found in 91·1 % of the children. S-25(OH)D concentration was not related to gender, socio-economic indicators, sun exposure or nutritional status. Currently breast-fed children had higher s-25(OH)D concentrations (36·4 (SD 13·2) nmol/l) than those who were not (28·6 (SD 9·8) nmol/l, P < 0·001). Adjustment for sociodemographic factors did not alter the results. Conclusion: There is widespread vitamin D deficiency among pre-school children in a rural area of Nepal. In our sample, sociodemographic factors did not affect the vitamin D status of children, but prolonged breast-feeding was associated with higher s-25(OH)D concentrations. Further research is required to investigate the health consequences of poor vitamin D status for this population. Low levels of vitamin D are reported in diverse populations around the world (1-3) , with one review suggesting that as many as 14 % of the world's population have levels inadequate for general well-being (4) . Serum concentration of 25-hydroxyvitamin D (s-25(OH)D) is the standard assessment for vitamin D status in the body and s-25(OH)D concentration of 50 nmol/l or more is considered sufficient for optimal bone-related health outcomes by the Institute of Medicine (5) . Studies from Turkey, the Middle East and India have revealed that up to 50 % of children have vitamin D deficiency (6) . A number of determinants that affect s-25(OH)D concentration in children have been identified and include skin pigmentation, prolonged breast-feeding without vitamin D supplementation and low consumption of foods rich in vitamin D (7) . However, little is known about the vitamin D status of Nepalese children.Nepal is a predominantly Hindu nation bordering Tibet and India, located between the latitudes of 26°N and 31°N. Nepalese cultural values do not restrict sun exposure and about 300 d per year are sunny (8) . A few studies that have investigated vitamin D status in special groups in Nepal, such as pregnant women and alcohol-abusing populations, report a wide range of vitamin D deficiency prevalence rat...

show abstract

A global representation of vitamin D status in healthy populations

Cited by 271 publications

References 208 publications

Peripheral Plasma Vitamin D and Non-HDL Cholesterol Reflect the Severity of Cerebral Cavernous Malformation Disease

Peripheral Plasma Vitamin D and Non-HDL Cholesterol Reflect the Severity of Cerebral Cavernous Malformation Disease

Vitamin D and bone health outcomes in older age

Vitamin D status in pre-school children in rural Nepal

Contact Info

Product

Resources

About