A Global Evaluation of the Performance Indicators of Colorectal Cancer Screening with Fecal Immunochemical Tests and Colonoscopy: A Systematic Review and Meta-Analysis

Ding, Hanyue; Lin, Jiaye; Xu, Zuo-Feng; Chen, Xiao; Wang, Haoxiang; Huang, Liwen; Huang, Junjie; Zheng, Zhi‐Jie; Wong, Martin C. S.

doi:10.3390/cancers14041073

Cited by 14 publications

(7 citation statements)

References 27 publications

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“…Additionally, a single study reported FIT’s sensitivity for proximal CRC is notably lower than for distal CRC, with a significant difference (71.1% vs 94.2%, p<0.001) 27. Furthermore, the participation rate in FIT screening hovers around 50% 28 29. In contrast, exhaled H 2 S analysis offers a breakthrough by addressing the limitations associated with bleeding and eliminating the influence of other haemorrhagic conditions on FIT results, such as haemorrhoids.…”

Section: Discussionmentioning

confidence: 99%

Role of exhaled hydrogen sulfide in the diagnosis of colorectal cancer

Du,

Tseng,

Liu

et al. 2024

BMJ Open Gastroenterol

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BackgroundColorectal cancer (CRC) is often accompanied by increased excretion of hydrogen sulfide (H2S). This study aimed to explore the value of exhaled H2S in the diagnosis of CRC.MethodsA total of 80 people with normal colonoscopy results and 57 patients with CRC were enrolled into the present observational cohort study. Exhaled oral and nasal H2S were detected by Nanocoulomb breath analyser. Results were compared between the two groups. Receiver operating characteristic (ROC) curves were analysed and area under the curves (AUCs) were calculated to assess the diagnostic value of exhaled H2S. Meanwhile, the clinicopathological features, including gender, lesion location and tumour staging of patients with CRC, were also collected and analysed.ResultsThe amount of exhaled H2S from patients with CRC was significantly higher than that of those with normal colonoscopy results. The ROC curve showed an AUC value of 0.73 and 0.71 based on oral and nasal H2S detection, respectively. The exhaled H2S in patients with CRC was correlated with gender, lesion location and tumour progression, including depth of invasion, lymphatic metastasis and TNM (Tumor, Lymph Nodes, Metastasis) staging.ConclusionExhaled H2S analysis is a convenient and non-invasive detection method for diagnosing CRC, suggesting a potential role in population screening for CRC.

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Section: Discussionmentioning

confidence: 99%

Role of exhaled hydrogen sulfide in the diagnosis of colorectal cancer

Du,

Tseng,

Liu

et al. 2024

BMJ Open Gastroenterol

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“…The studies showed that people were more likely to participate in the FIT screening than in the screening using colonoscopy [ 14 , 41 , 42 ] or sigmoidoscopy [ 9 ]. In countries where CRC screening is based on FIT, the median reporting rate is 54% [95% CI: (49.28%; 58.69%)] [ 43 ]. For comparison in Poland, where the screening program is based solely on colonoscopy (in a system where the potential participant receives a personal invitation to the study), it is below 20% [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Effectiveness of Faecal Immunochemical Test in the Early Detection of Colorectal Cancer—An Umbrella Review

Świtalski

Tatara²,

Wnuk³

et al. 2022

Cancers

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Introduction: The colorectal cancer prognosis depends on the stage of the neoplasm; therefore, its early detection plays an important role. The aim of the study is evaluation of the sensitivity, specificity, and clinical effectiveness of the faecal immunochemical test in the early colorectal cancer detection. Methods: The clinical analysis was based on the results of the studies included in a systematic review conducted in accordance with the Cochrane Collaboration guidelines. The following medical information sources were searched: Medline (via PubMed), Embase (via Ovid), The Cochrane Library. Results: From 241 citations, 13 studies were included in this review. All included studies had a low risk of bias. The faecal immunochemical test is highly specific in all analysed populations ranging from 85% to 97%. In most of the found studies, sensitivity is over 75%. The faecal immunochemical test screening also determines a reduction in death (10–59%) due to colorectal cancer. Conclusions: The faecal immunochemical test is an effective and cost-effective method of conducting population-wide colorectal cancer screening. It is an alternative or complementary to other screening tests, including colonoscopy.

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“…[37,38] In relation to CRC, its prevalence in colonoscopic studies ranges from 0.28-0.42% for all types of CRC. [39,40] As the serrated pathway accounts for up to 30% of CRC, the small number of SAC serum samples available for our study was expected. This precluded the construction of cfDNA pooled samples from SAC cases, that therefore were retained for the biomarker evaluation phase.…”

Section: Discussionmentioning

confidence: 99%

Serum DNA methylome of the colorectal cancer serrated pathway

Gallardo-Gómez

Costas-Rios

García-Prieto

et al. 2022

Preprint

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Objective: The clinical relevance of the serrated pathway of colorectal carcinogenesis is evident but the screening of serrated lesions remains challenging. We aimed to characterize the serum methylome of the serrated pathway, and to evaluate circulating cell-free DNA (cfDNA) methylation as a source of biomarkers for the non-invasive screening and diagnosis of serrated lesions. Design: We collected serum samples from individuals with serrated adenocarcinoma (SAC), traditional serrated adenomas, sessile serrated lesions, hyperplastic polyps and with no colorectal findings. First, epigenome-wide methylation was quantified in cfDNA pooled samples with the MethylationEPIC array. Then, methylation profiles were compared to tissue and serum cfDNA datasets. Finally, biomarker utility of serum cfDNA methylation was evaluated. Results: We identified a differential methylation profile that can distinguish high-risk serrated lesions from the absence of serrated neoplasia, showing concordance with tissue methylation from SAC and sessile serrated lesions (external datasets). We report that the methylation profiles in serum cfDNA are pathway-specific, clearly separating serrated lesions from conventional adenomas. Among the differentially methylated regions (DMR) we report, the combination of two DMRs within the genes NINJ2 and ERICH1 discriminated high-risk serrated lesions and SAC with 91.4% sensitivity and 64.4% specificity, while methylation from a DMR within ZNF718 reported 100% sensitivity for the detection of SAC at 96% specificity. Conclusion: This is the only study available to date exploring the serum methylome of serrated lesions. We have identified a differential methylation profile in serum specific to the serrated pathway. The serum methylome may serve as a source of non-invasive biomarkers for screening and detection of high-risk serrated lesions.

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A Global Evaluation of the Performance Indicators of Colorectal Cancer Screening with Fecal Immunochemical Tests and Colonoscopy: A Systematic Review and Meta-Analysis

Cited by 14 publications

References 27 publications

Role of exhaled hydrogen sulfide in the diagnosis of colorectal cancer

Role of exhaled hydrogen sulfide in the diagnosis of colorectal cancer

Clinical Effectiveness of Faecal Immunochemical Test in the Early Detection of Colorectal Cancer—An Umbrella Review

Serum DNA methylome of the colorectal cancer serrated pathway

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