Abstract:Objective: The clinical relevance of the serrated pathway of colorectal carcinogenesis is evident but the screening of serrated lesions remains challenging. We aimed to characterize the serum methylome of the serrated pathway, and to evaluate circulating cell-free DNA (cfDNA) methylation as a source of biomarkers for the non-invasive screening and diagnosis of serrated lesions.
Design: We collected serum samples from individuals with serrated adenocarcinoma (SAC), traditional serrated adenomas, sessile serrate… Show more
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